Surfactant-aided size-exclusion chromatography for the purification of immunoglobulin G

Horneman, D.A.; Ottens, Marcel; Keurentjes, J.T.F.; Wielen, Luuk A.M. van der

doi:10.1016/j.chroma.2007.05.014

Cited by 21 publications

(8 citation statements)

References 19 publications

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“…Therefore SMB technology has been applied in many fields, including petroleum (Broughton, 1984;Lim, 2012), food (Ching & Ruthven, 1985;Beste et al, 2000), biotechnology (Horneman et al 2007;Andersson et al 2008;Li et al 2007;Gueorguieva et al, 2011), pharmaceutical and fine chemical industries (Negawa & Shoji, 1992;Pais et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Continuous prediction technique for fast determination of cyclic steady state in simulated moving bed process

Yao

Tang

Yao

et al. 2013

Computers & Chemical Engineering

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In the simulation of cyclic processes, such as simulated moving bed (SMB), the system should be equilibrated to reach a cyclic steady state (CSS) before evaluating the process performance. However, the conventional method of successive substitution is quite time-consuming. In this work, a continuous predicting method (CPM) is developed for fast determination of CSS in SMB. In CPM, the direct prediction of state variable at CSS and solving model equation are conducted alternately until CSS is reached. In order to give a guideline for the selection of the acceleration factor, CPM is applied on SMB process for enantioseparation of 1,1'-bi-2-naphtol racemate and with the optimized acceleration factor, 59% of computation time saved compared with successive substitution. In addition, this method is further successfully used in a sugar separation process. Given its efficiency and simplicity, this method could provide a useful tool for SMB simulations.

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Section: Introductionmentioning

confidence: 99%

Continuous prediction technique for fast determination of cyclic steady state in simulated moving bed process

Yao

Tang

Yao

et al. 2013

Computers & Chemical Engineering

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“…Such advantages include: less column material requirement, less product dilution and lower eluent consumption. These advantages are more pronounced when SMB is applied to size-exclusion chromatography, as has already been shown in the context of conventional separations (Horneman et al, 2007a(Horneman et al, , 2007b. However, this still needs to be addressed in the context of size-exclusion chromatographic refolding reactors.…”

Section: Article In Pressmentioning

confidence: 90%

“…The application of SMB technology has been already demonstrated for the purification of biomolecules. Examples include: insulin (Xie et al, 2002), human bone morphogenetic protein-2 (Gueorguieva et al, 2006), a-lactalbumin and b-lactoblobulin (Lucena et al, 2002), immunoglobulin G and viral clearance (Horneman et al, 2007a(Horneman et al, , 2007b. SMB technology has inherent advantages over conventional batch chromatography.…”

Section: Article In Pressmentioning

confidence: 99%

Size-exclusion simulated moving bed chromatographic protein refolding

Freydell¹,

Bulsink²,

Hateren³

et al. 2010

Chemical Engineering Science

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“…The basic method may be modified to gain insight into the quality of aggregates, for instance by addition of denaturant to the eluent (19). This can disperse non-covalently associated aggregates.…”

Section: Techniques To Analyze Protein Aggregatesmentioning

confidence: 99%

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

et al. 2010

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Within the European Immunogenicity Platform (EIP) (http://www.e-i-p.eu), the Protein Characterization Subcommittee (EIP-PCS) has been established to discuss and exchange experience of protein characterization in relation to unwanted immunogenicity. In this commentary, we, as representatives of EIP-PCS, review the current state of methods for analysis of protein aggregates. Moreover, we elaborate on why these methods should be used during product development and make recommendations to the biotech community with regard to strategies for their application during the development of protein therapeutics.

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Surfactant-aided size-exclusion chromatography for the purification of immunoglobulin G

Cited by 21 publications

References 19 publications

Continuous prediction technique for fast determination of cyclic steady state in simulated moving bed process

Continuous prediction technique for fast determination of cyclic steady state in simulated moving bed process

Size-exclusion simulated moving bed chromatographic protein refolding

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

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