Surfactant-assisted controlled release of hydrophobic drugs using anionic surfactant templated mesoporous silica nanoparticles

Tsai, Chih-Hsiang; Vivero‐Escoto, Juan L.; Slowing, Igor I.; Fang, I-Ju; Trewyn, Brian G.; Lin, Victor S.-Y.

doi:10.1016/j.biomaterials.2011.04.077

Cited by 75 publications

(42 citation statements)

References 63 publications

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“…Up to date, many materials, eg, liposomes, block copolymers, dendrimers, and various inorganic nanomaterials, have been utilized as drug carriers in DDS. [3][4][5][6] Among them, mesoporous silica nanoparticles (MSNs) have attracted more and more attention as a promising component, [7][8][9][10][11][12][13] they are excellent candidates for many biomedical applications owing to their high specific surface area, large pore volume, tunable pore structures and well-defined surface property for modification.…”

Section: Introductionmentioning

confidence: 99%

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Qin²,

Fan³

2012

IJN

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Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dynamic light scattering, fourier transform infrared spectroscopy and transmission electron microscopy. The resultant NMChS-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 74 nm. Due to the covalent graft of hydrophilic and pH responsive NMChS, the NMChS-MSNs could be well dispersed in aqueous solution, which is favorable to being utilized as drug carriers to construct a pH-responsive controlled drug delivery system. Doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of NMChS-MSNs through electrostatic interactions between drug and matrix. The drug release rate of DOX@NMChS-MSNs was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that NMChS-MSNs were highly biocompatible and suitable to use as drug carriers. Our results imply that chondroitin sulfate functionalized nanoparticles are promising platforms to construct the pH-responsive controlled drug delivery systems for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Qin²,

Fan³

2012

IJN

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“…Because the marked cytotoxicity of CTAB was reported by other researchers [36], fouriertransform infrared spectra (FTIR) analysis was carried out to confirm the complete removal of CTAB. Typically, CTAB shows two intense peaks at 2800-3200 cm ) stretching vibrations of the methylene chains ( Figure 5).…”

Section: Preparation and Characterization Of Msns And Lac-msnsmentioning

confidence: 99%

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Quan¹,

Pan²,

Wang³

et al. 2016

Nano Online

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Background: Mesoporous silica nanoparticles (MSNs) have several attractive properties as a drug delivery system, such as ordered porous structure, large surface area, controllable particle size as well as interior and exterior dual-functional surfaces. The purpose of this study was to develop novel lactosaminated mesoporous silica nanoparticles (Lac-MSNs) for asialoglycoprotein receptor (ASGPR) targeted anticancer drug delivery.

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“…It was done by shaking the LVF-MSN in PBS solution at 37°C. Figure 6a shows that have been previously reported and it was observed that pore sizes of nanoparticles determine the release kinetics [28,31]. In this study, the release of LVF from four different types of materials was measured by shaking in PBS solution at 37°C.…”

Section: Cumulative Release Of Lvfmentioning

confidence: 89%

“…Mesoporous silica nanoparticles (MSN) have been used as a nanocarrier of drugs due to their unique properties such as high specific surface area, high pore volumes and the presence of reactive groups for further functionalisation, i.e. covalent conjugation to a drug [27][28][29][30][31]. Also MSN show good biocompatibility with no cytotoxicity to cells in vitro, and silica-based implants show no toxicity to liver, kidney or lymph nodes in animals.…”

Section: Introductionmentioning

confidence: 99%

Release and antimicrobial activity of levofloxacin from composite mats of poly(ɛ-caprolactone) and mesoporous silica nanoparticles fabricated by core–shell electrospinning

et al. 2015

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Nanofibrous materials have often been reported as carriers for clinical drugs but face the limitation of releasing the drugs in a burst fashion during use. The aim of this study is to produce composite nanofibrous mats with sustained release, using the broad spectrum antibiotic levofloxacin (LVF) as a model. Sustained release was achieved through two approaches, i.e. by firstly loading LVF into mesoporous silica nanoparticles (MSN) and then incorporating the MSN in the core regions of poly(ecaprolactone) (PCL) nanofibres via core-shell electrospinning. Uniform PCL/LVF nanofibrous mats were also produced as controls. Loading of LVF into the MSN nanopores was confirmed by FTIR, BJH and BET measurements (100 mg LVF/g MSN). After electrospinning, electron microscopy revealed that the MSN were indeed confined in the core regions of the nanofibres. Drug release profiles showed that burst release was decreased from 59 % in the uniform PCL/LVF electrospun mats to 39 % in the core-shell PCL/LVF-MSN mats after 1 day in phosphate buffer at 37°C, and gradual release in the latter was observed over the next 13 days. Antimicrobial assays showed that the composite electrospun mats were highly effective in killing Escherichia coli even after the mats had been incubated in a phosphate buffer for 14 days while the uniform PCL/LVF mats lost the ability after only 7 days. The results indicate that adsorption of the drug onto MSN and confining them in the core of nanofibres are effective ways of minimizing burst release and achieving sustained release of the drug.

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Surfactant-assisted controlled release of hydrophobic drugs using anionic surfactant templated mesoporous silica nanoparticles

Cited by 75 publications

References 63 publications

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Release and antimicrobial activity of levofloxacin from composite mats of poly(ɛ-caprolactone) and mesoporous silica nanoparticles fabricated by core–shell electrospinning

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