2017
DOI: 10.1039/c6py02158a
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Surfactant-free RAFT emulsion polymerization using a novel biocompatible thermoresponsive polymer

Abstract: A facile, high-scale, and versatile technique to prepare biocompatible nanoparticles with tailorable properties from thermoresponsive macro-CTAs and macro-stabilizers.

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Cited by 63 publications
(55 citation statements)
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“…Emulsions were homogenized and heated at 70 °C for 3 h. Emulsion polymerizations were performed with five different DP target (50, 75, 100, 150, and 200) for the third, core‐forming block, resulting in a library of five P( t ‐BA) and five P( n ‐BA) core–shell nanoparticles. Syntheses were performed up to 8.4 wt% monomer at 10 mL scales (84 mg mL −1 ), which could be easily scaled up to multi‐gram reactions . Full monomer conversion was attained in under 3 h, due to the well‐established compartmentalization effects found in emulsion polymerization.…”
Section: Resultsmentioning
confidence: 99%
“…Emulsions were homogenized and heated at 70 °C for 3 h. Emulsion polymerizations were performed with five different DP target (50, 75, 100, 150, and 200) for the third, core‐forming block, resulting in a library of five P( t ‐BA) and five P( n ‐BA) core–shell nanoparticles. Syntheses were performed up to 8.4 wt% monomer at 10 mL scales (84 mg mL −1 ), which could be easily scaled up to multi‐gram reactions . Full monomer conversion was attained in under 3 h, due to the well‐established compartmentalization effects found in emulsion polymerization.…”
Section: Resultsmentioning
confidence: 99%
“…Further, the filomicelle morphology could be obtained for polystyrene, PBzMA, PMMA, PEMA, and PPMA cores . Moreover, by randomly incorporating a hydrophilic component with ≈21 ethylene glycol units on the side chain of PDEGMA‐ co ‐PHPMA, sphere, worms, and vesicles were successfully prepared by surfactant‐free RAFT emulsion polymerization . Significantly, noncross‐linked nano‐objects prepared by RAFT emulsion polymerization using PDEGMA‐ co ‐PHPMA as a macro‐CTA are tolerant to high concentration of surfactants, thus overcoming the surfactant tolerance challenge mentioned in earlier critical appraisals of PISA …”
Section: Raft Emulsion Polymerizationmentioning
confidence: 99%
“…Emulsion polymerization is an industrially favored technique for synthesizing many types of polymers due to its favorable kinetics, the high specific heat capacity of water and the low viscosity of the final polymer product . One major use of emulsion polymerization is the facile synthesis of functional polymer nanoparticles . A classic emulsion polymerization uses a surfactant, such as sodium dodecyl sulfate, to provide nucleation sites for growing “z‐mer” polymer chains and particle stabilization.…”
Section: Introductionmentioning
confidence: 99%
“…However, particles made using a surfactant must then be extensively dialyzed to remove the surfactant for use in applications such as drug delivery and photonics . There has therefore been a large amount of research into synthesizing functional nanoparticles with diameters under 100 nm using “surfactant free” controlled radical polymerization . One such technique is reversible addition‐fragmentation chain transfer emulsion polymerization, in which a short amphiphilic di‐block copolymer is prepared, then suspended in water to act as a surfactant for the emulsion polymerization.…”
Section: Introductionmentioning
confidence: 99%