Surfactant Protein A (SP-A) and Angiotensin Converting Enzyme (ACE) as Early Biomarkers for Pulmonary Edema Formation in Ventilated Human Lung Lobes

Abstract

We suggest that SP-A and ACE are promising early biochemical markers for the development for pulmonary edema formation in the ex vivo lung lobe perfusion.

Human Pulmonary 3D Models For Translational Research

“…A small number of groups investigated isolated, ex vivo perfused, and ventilated human lungs or lobes . In these models, lung tissue was perfused via the cannulated pulmonary artery with cell free perfusion media, with cell‐containing (e.g., diluted whole human blood preparations) solutions, or solutions for lung preservation during transport before transplantation .…”

“…In these models, lung tissue was perfused via the cannulated pulmonary artery with cell free perfusion media, with cell‐containing (e.g., diluted whole human blood preparations) solutions, or solutions for lung preservation during transport before transplantation . The lungs were ventilated via the natural airways for up to 24 h. Such limited available and technically elaborated models allow for the investigation of lung edema formation, oxygenation capacity, vascular reactivity, bacterial infection, and innovative therapeutic approaches such as stem cell therapies . These examples demonstrate that there are multiple, scalable approaches of different complexity to use living human lung tissue in its original tissue architecture for experimental research and testing of new clinical interventions.…”