Surfactant protein D multimerization and gene polymorphism in COPD and asthma

Fakih, Dalia; Akiki, Zeina; Junker, Kirsten; Medlej‐Hashim, Myrna; Waked, Mirna; Salameh, Pascale; Holmskov, Uffe; Bouharoun-Tayoun, Hasnaa; Chamat, Soulaïma; Sørensen, Grith Lykke; Jounblat, Rania

doi:10.1111/resp.13193

Cited by 23 publications

(18 citation statements)

References 42 publications

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“…Some researchers have studied the association between SPD polymorphisms and COPD susceptibility; this association was first reported in the Mexican population in 2001 26. Some studies have reported that the SPD gene plays an important role in the development of asthma 15, silicosis 27 and tuberculosis 28. However, there is still controversy concerning the genetic associations of SPD with COPD at present.…”

Section: Discussionmentioning

confidence: 99%

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Liao¹,

Huang²,

Wang³

et al. 2019

Clinics

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The relationship between surfactant-associated protein D polymorphisms and chronic obstructive pulmonary disease risk remains controversial. This article is the first to systematically evaluate this relationship. A comprehensive worldwide search was conducted for relevant literature on surfactant-associated protein D gene mutations and chronic obstructive pulmonary disease risk prediction. Study quality was evaluated using the Newcastle-Ottawa scale. After four genetic models (the allele, additive, recessive, and dominant models) were identified, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were applied in this meta-analysis. The meta-analysis included 659 individuals in the case group and 597 in the control group. In the Asian population, none of the four genetic models revealed any significant association between rs2243639 genotype and the risk of chronic obstructive pulmonary disease. In Caucasians, however, the recessive model exhibited significant risk associated with rs2243639. Furthermore, there was a significant association between rs721917 genotype and the risk of chronic obstructive pulmonary disease in the Asian population. In contrast, none of the four gene models revealed any significant risk associated with this gene in the Caucasian population. This meta-analysis suggests that rs2243639 is not related to the risk of chronic obstructive pulmonary disease in the Asian population but is related to this risk in the Caucasian population. Regarding rs721917, the T allele may increase the risk of chronic obstructive pulmonary disease in the Asian population.

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Section: Discussionmentioning

confidence: 99%

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Liao¹,

Huang²,

Wang³

et al. 2019

Clinics

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“…HMW SP-D multimers are only partly dependent on disulfide crosslinking of the N terminal region, and some SP-D subunits are non-covalently associated depending on the protein concentration in the solution ( 36 ). Several studies have shown some discrepancies in binding characteristics and activities between HMW and LMW SP-D ( 36 , 37 , 43 ). Second, we were not able to demonstrate in vivo effects of the genetic variants of rSP-D in a TB-infected animal model due to a small yield of recombinant full-length human SP-D from HEK 293 cells.…”

Section: Discussionmentioning

confidence: 99%

Functional Analysis of Genetic Variations in Surfactant Protein D in Mycobacterial Infection and Their Association With Tuberculosis

Hsieh

et al. 2018

Front. Immunol.

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Surfactant proteins (SPs)-A and -D are C-type lectins of the collectin family and function in the clearance of infectious particles in the lungs. Some polymorphisms of SPs that give rise to amino acid changes have been found to affect their function. Several SP-A gene polymorphisms have been reported to be associated with respiratory infection diseases, such as tuberculosis (TB). However, the relationship between surfactant proteins D (SP-D) polymorphisms and TB is still unclear. To study the associations between SP-D polymorphisms and TB, the correlations of SP-D polymorphisms with TB were examined in a case–control study, which included 364 patients with TB and 177 control subjects. In addition, we cloned two major SP-D exonic polymorphism C92T (rs721917) and A538G (rs2243639) constructs and used these for in vitro assays. The effects of SP-D polymorphisms on agglutination and other interactions with Mycobacterium bovis bacillus Calmette–Guérin (M. bovis BCG) were evaluated. In comparison with SP-D 92C (amino acid residue 16, Threonine), our results showed that SP-D 92T (amino acid residue 16, Methionine) had a lower binding ability to M. bovis BCG, a lower capacity to inhibit phagocytosis, lesser aggregation, poorer survival of bacillus Calmette–Guérin (BCG)-infected MH-S cells, and less inhibition of intracellular growth of M. bovis BCG. The case–control association study showed that the 92T homozygous genotype was a risk factor for TB. However, a lesser effect was seen for polymorphism A538G. In conclusion, the results of functional and genetic analyses of SP-D variants consistently showed that the SP-D 92T variant increased susceptibility to TB, which further confirmed the role of SP-D in pulmonary innate immunity against mycobacterial infection.

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“…Fakih et al . described changes in the ratio of high‐molecular weight to low‐molecular weight surfactant protein D in serum from a large group of COPD and asthma patients . These findings suggest the need to use assays that distinguish between different forms of surfactant protein D …”

Section: Copdmentioning

confidence: 93%

Contemporary Concise Review 2018: Asthma and chronic obstructive pulmonary disease

Upham

2019

Respirology

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Surfactant protein D multimerization and gene polymorphism in COPD and asthma

Cited by 23 publications

References 42 publications

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Functional Analysis of Genetic Variations in Surfactant Protein D in Mycobacterial Infection and Their Association With Tuberculosis

Contemporary Concise Review 2018: Asthma and chronic obstructive pulmonary disease

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