Surfactant protein gene expressions for detection of lung carcinoma cells in peripheral blood

Yamamoto, O; Takahashi, Hiroki; Hirasawa, Michio; Chiba, Hirofumi; Shiratori, Masanori; Kuroki, Yoshio; Abe, Shosaku

doi:10.1016/j.rmed.2005.02.009

Cited by 13 publications

(10 citation statements)

References 33 publications

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“…2 supports this fact. This result along with some earlier investigations [9,51,26,41] ensures that these genes may be responsible to develop tumor cells in lung.…”

Section: Surfactant Protein (Sftp)supporting

confidence: 76%

Linguistic recognition system for identification of some possible genes mediating the development of lung adenocarcinoma

Ghosh²

2009

Information Fusion

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“…2 supports this fact. This result along with some earlier investigations [9,51,26,41] ensures that these genes may be responsible to develop tumor cells in lung.…”

Section: Surfactant Protein (Sftp)supporting

confidence: 76%

Linguistic recognition system for identification of some possible genes mediating the development of lung adenocarcinoma

Ghosh²

2009

Information Fusion

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“…Cancer prognosis is related to tumor metastases that are believed to arise from circulating tumor cells (CTCs) that move into the peripheral blood 4,5. In addition, CTC counts are reported to be closely linked to lung cancer outcomes 6,7.…”

Section: Introductionmentioning

confidence: 99%

Correlation between epidermal growth factor receptor tyrosine kinase inhibitor efficacy and circulating tumor cell levels in patients with advanced non-small cell lung cancer

He¹,

Li²,

Jiang³

et al. 2016

OTT

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ObjectiveThe aim of this study was to investigate the correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and circulating tumor cell (CTC) levels in patients with advanced non-small cell lung cancer (NSCLC). The efficacy of EGFR-TKIs in reducing CTC counts in patients with advanced NSCLC was studied.Patients and methodsA total of 66 patients with advanced NSCLC were enrolled and divided into two groups (those with high CTC counts and those with low CTC counts) based on the patients’ median CTC counts. All the patients were treated with an EGFR-TKI, and the treatment efficacy and prognoses were compared.ResultsThe treatment efficacies were 53.3% (16/30) and 27.8% (10/36) for the low CTC group and high CTC group, respectively, and this difference was statistically significant (P<0.05). The median overall survival was 22.8 months (95% confidence interval [CI]: 18.9–26.8 months) for the low CTC group and 18.3 months (95% CI: 2.9–8.2 months) for the high CTC group. The median progression-free survival was 11.5 months (95% CI: 8.1–15 months) and 5.6 months (95% CI: 2.9–8.2 months) for the low and high CTC groups, respectively, and the difference was statistically significant (P<0.05).ConclusionThe CTC count can be used as an index for predicting the EGFR-TKI effect on patients with advanced NSCLC. Efficacy and prognosis of EGFR-TKI treatment and CTC count were considered important, and the CTC count could be used to predict the efficacy of EGFR-TKI treatment and prognosis of advanced NSCLC. The change in CTC expression levels can be used as an index for evaluating the prognosis of patients with advanced NSCLC.

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“…It is possible that under normal conditions, the health status of the tissue is partly maintained via a delicate balance between inhibitory and stimulatory activities of SP-A and SP-D. We speculate that in lung cancer this fine balance is disturbed with increased levels of SP-A due to its hypomethylation status. In fact increased levels of SP-A mRNA have been observed in peripheral blood from patients with lung carcinomas (40). Moreover, it has been shown that SP-A-producing cells may generate a number of lung cancers (41).…”

Section: Discussionmentioning

confidence: 99%

DNA methylation markers of surfactant proteins in lung cancer

et al. 2007

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Abstract. Surfactant proteins play important roles in lung surfactant function and innate immunity. The DNA methylation state of 11 CpG sites of surfactant protein (SP)-A1, -B, -C, and -D was determined using universal bead arrays. A total of 90 cancerous and non-cancerous tissues from 23 patients with adenocarcinoma and 22 with squamous cell carcinoma were studied. These were divided into a training set and a testing set. The results indicate that DNA methylation profiling of these CpGs is associated with lung cancer. Four CpG sites, SP-A1_370, SP-A1_1080, SP-D_1170, and SP-D_1370, were hypomethylated in cancer and were significantly associated with both adenocarcinoma and squamous cell carcinoma, indicating that they have the potential to be used as biomarkers for lung cancer diagnosis and treatment. Normal lung tissues with a higher level of unmethylated SP-A1_1468 and SP-D_1170 CpG exhibited a higher level of SP-A1 and SP-D gene transcripts indicating that CpG methylation may play a role in gene expression. When the non-cancerous tissues were compared to cancerous tissues in patients with adenocarcinoma, the methylation profile results of these 46 samples (23 cancerous and 23 non-cancerous) could be clustered into 4 groups by agglomerative nesting. The percentage of tumor samples in each group was 0, 58, 91, and 100, respectively. A similar pattern was observed in squamous cell carcinoma patients. We speculate that SP-A1 and SP-D are subject to methylation/demethylation regulatory mechanisms and are involved in lung cancer pathogenesis by virtue of their function in innate host defense and/or regulation of inflammation.

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Surfactant protein gene expressions for detection of lung carcinoma cells in peripheral blood

Abstract: These results demonstrate that the detection of mRNA of SP-A and SP-C would give clinicians valuable information suggesting the presence of blood-floating carcinoma cells as a step toward metastasis.

Cited by 13 publications

References 33 publications

Linguistic recognition system for identification of some possible genes mediating the development of lung adenocarcinoma

Linguistic recognition system for identification of some possible genes mediating the development of lung adenocarcinoma

Correlation between epidermal growth factor receptor tyrosine kinase inhibitor efficacy and circulating tumor cell levels in patients with advanced non-small cell lung cancer

DNA methylation markers of surfactant proteins in lung cancer

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