1987
DOI: 10.1016/0166-6622(87)80200-7
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Surfactants and the stratum corneum lipids

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Cited by 24 publications
(10 citation statements)
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“…SLS may become intercalated into intercellular lipid bilayers, thus disrupting normal keratinocyte cohesion and facilitating desquamation. In support of this speculation, SLS incorporation alters lipid packing and reduces the degree of organisation of a model stratum corneum (Friberg et al, 1988). Alternatively SLS is capable of denaturing keratin (Rhein et al, 1986), and may therefore denature the proteinaceous structure of desmosomes and their associated intracellular tonofilaments.…”
Section: Discussionmentioning
confidence: 98%
“…SLS may become intercalated into intercellular lipid bilayers, thus disrupting normal keratinocyte cohesion and facilitating desquamation. In support of this speculation, SLS incorporation alters lipid packing and reduces the degree of organisation of a model stratum corneum (Friberg et al, 1988). Alternatively SLS is capable of denaturing keratin (Rhein et al, 1986), and may therefore denature the proteinaceous structure of desmosomes and their associated intracellular tonofilaments.…”
Section: Discussionmentioning
confidence: 98%
“…Even when the amount of lipid removed is only small [14] the selective removal of free fatty acids and cholesterol esters can lead to a significant alteration in the composition of the intercellular lipids [8, 15, 16]. In addition, surfactants penetrate the stratum corneum, adsorb on the keratin of the corneocytes [17] and mix themselves with the intercellular lipids [18]. The result is an impairment of the skin barrier, which can be demonstrated with great sensitivity by the TEWL‐measurement.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, Friberget al [32] have incorporated SLS (and other surfactants) into a model of SC lipid, where it altered the interlayer spacing of the bilayer, indicating a change in lipid-packing arrangements. Thus, surfactants may be expected to damage lipid structure/function in intact SC via this mech anism.…”
Section: Relation O F Sc Lipid Removal To In Vivo Surfactant Effectsmentioning
confidence: 99%