Surfactin exerts an anti-cancer effect through inducing allergic reactions in melanoma skin cancer

Kim, Hee-Yun; Jung, Hanchul; Kim, Hyung-Min; Jeong, Hyun‐Ja

doi:10.1016/j.intimp.2021.107934

Cited by 20 publications

(17 citation statements)

References 54 publications

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“…34,35 An increase in infiltrating mast cells was a poor prognostic factor in human melanomas; however, oral administration of mast cell degranulator increased the infiltration of mast cells and levels of histamine and IL-6, resulting in suppression of melanoma growth in vivo. 36,37 It would be interesting to see whether elevated levels of histamine and inflammatory cytokines resulting from the activation of tissue-infiltrating mast cells have opposite effects in prostate cancer and melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…In human breast cancer, mast cell counts were higher with favorable molecular subtypes, including luminal A and luminal B; however, the correlation between the number of ER‐positive cancer cells and mast cells in high‐grade tumors suggested that ER stimulation by mast cells might play a role in breast cancer progression 34,35 . An increase in infiltrating mast cells was a poor prognostic factor in human melanomas; however, oral administration of mast cell degranulator increased the infiltration of mast cells and levels of histamine and IL‐6, resulting in suppression of melanoma growth in vivo 36,37 . It would be interesting to see whether elevated levels of histamine and inflammatory cytokines resulting from the activation of tissue‐infiltrating mast cells have opposite effects in prostate cancer and melanoma.…”

Section: Discussionmentioning

confidence: 99%

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High‐fat diet promotes prostate cancer growth through histamine signaling

Matsushita

Fujita

Hatano

et al. 2022

Intl Journal of Cancer

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Western high‐fat diets (HFD) are regarded as a major risk factor for prostate cancer (PCa). Using prostate‐specific Pten‐knockout mice as a PCa model, we previously reported that HFD promoted inflammatory PCa growth. The composition of the gut microbiota changes under the influence of diet exert various effects on the host through immunological mechanisms. Herein, we investigated the etiology of HFD‐induced inflammatory cancer growth and the involvement of the gut microbiome. The expression of Hdc, the gene responsible for histamine biosynthesis, and histamine levels were upregulated in large prostate tumors of HFD‐fed mice, and the number of mast cells increased around the tumor foci. Administration of fexofenadine, a histamine H1 receptor antagonist, suppressed tumor growth in HFD‐fed mice by reducing the number of myeloid‐derived suppressor cells and suppressing IL6/STAT3 signaling. HFD intake induced gut dysbiosis, resulting in the elevation of serum lipopolysaccharide (LPS) levels. Intraperitoneal injection of LPS increased Hdc expression in PCa. Inhibition of LPS/Toll‐like receptor 4 signaling suppressed HFD‐induced tumor growth. The number of mast cells increased around the cancer foci in total prostatectomy specimens of severely obese patients. In conclusion, HFD promotes PCa growth through histamine signaling via mast cells. Dietary high‐fat induced gut dysbiosis might be involved in the inflammatory cancer growth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High‐fat diet promotes prostate cancer growth through histamine signaling

Matsushita

Fujita

Hatano

et al. 2022

Intl Journal of Cancer

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“…To discriminate antitumorogenic effects of specific proteases from the effects of a great amount of biologically active substances of the entire secretome is rather complicated; it has been observed that allergic reactions, in which massive degranulation of mast cells occurs, lead to regression of melanoma [ 45 ]. Significant antitumor effects were demonstrated in a study investigating possible effects of substances that enhanced mast cell degranulation.…”

Section: Discussionmentioning

confidence: 99%

Protease Profile of Tumor-Associated Mast Cells in Melanoma

Atiakshin

Kostin

Buchwalow

et al. 2022

IJMS

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Mast cells (MCs) produce a variety of mediators, including proteases—tryptase, chymase, and carboxypeptidases—which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.

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“…Moreover, these compounds exhibit antibacterial [ 5 , 10 ], antifungal [ 11 ], antiviral [ 12 ], and antitumor activities [ 13 ]. Their antiadhesive properties and antibiofilm activities are also important in inhibiting the adhesion and colonization of pathogenic microorganisms and removing preformed biofilms on silicone discs and other biomedical instruments [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Araújo

Monteiro

Silva³

et al. 2022

Antibiotics

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Surface-active compounds (SACs), biomolecules produced by bacteria, yeasts, and filamentous fungi, have interesting properties, such as the ability to interact with surfaces as well as hydrophobic or hydrophilic interfaces. Because of their advantages over other compounds, such as biodegradability, low toxicity, antimicrobial, and healing properties, SACs are attractive targets for research in various applications in medicine. As a result, a growing number of properties related to SAC production have been the subject of scientific research during the past decade, searching for potential future applications in biomedical, pharmaceutical, and therapeutic fields. This review aims to provide a comprehensive understanding of the potential of biosurfactants and emulsifiers as antimicrobials, modulators of virulence factors, anticancer agents, and wound healing agents in the field of biotechnology and biomedicine, to meet the increasing demand for safer medical and pharmacological therapies.

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Surfactin exerts an anti-cancer effect through inducing allergic reactions in melanoma skin cancer

Cited by 20 publications

References 54 publications

High‐fat diet promotes prostate cancer growth through histamine signaling

High‐fat diet promotes prostate cancer growth through histamine signaling

Protease Profile of Tumor-Associated Mast Cells in Melanoma

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

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