Surgery for cataracts in people with age-related macular degeneration

Casparis, Heather; Lindsley, Kristina; Kuo, Irene; Sikder, Shameema; Bressler, Neil M.

doi:10.1002/14651858.cd006757.pub3

Cited by 33 publications

(33 citation statements)

References 54 publications

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“…Some hypothesise that cataract surgery may increase the incidence of AMD and accelerate disease progression, possibly due to the induction of inflammatory reactions during and after surgery, and from increased exposure to ultraviolet light on the retina afterward . Others believe that cataract and AMD share environmental risk factors such as age, smoking, obesity, hypertension and sunlight exposure, and consequently, individuals who have had cataract surgery are automatically at higher risk for developing AMD as well . Besides, cataract surgery may even be beneficial for AMD patients in both visual acuity and quality‐of‐life parameters .…”

Section: Demographic and Environmental Risk Factorsmentioning

confidence: 99%

Risk factors for progression of age‐related macular degeneration

Heesterbeek

Lorés‐Motta

Hoyng

et al. 2020

Ophthalmic Physiologic Optic

255

224

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Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula, often leading to progressive vision loss. The rate of disease progression can vary among individuals and has been associated with multiple risk factors. In this review, we provide an overview of the current literature investigating phenotypic, demographic, environmental, genetic, and molecular risk factors, and propose the most consistently identified risk factors for disease progression in AMD based on these studies. Finally, we describe the potential use of these risk factors for personalised healthcare. Recent findings While phenotypic risk factors such as drusen and pigment abnormalities become more important to predict disease progression during the course of the disease, demographic, environmental, genetic and molecular risk factors are more valuable at earlier disease stages. Demographic and environmental risk factors such as age and smoking are consistently reported to be related to disease progression, while other factors such as sex, body mass index (BMI) and education are less often associated. Of all known AMD variants, variants that are most consistently reported with disease progression are rs10922109 and rs570618 in CFH, rs116503776 in C2/CFB/SKIV2L, rs3750846 in ARMS2/HTRA1 and rs2230199 in C3. However, it seems likely that other AMD variants also contribute to disease progression but to a lesser extent. Rare variants have probably a large effect on disease progression in highly affected families. Furthermore, current prediction models do not include molecular risk factors, while these factors can be measured accurately in the blood. Possible promising molecular risk factors are High‐Density Lipoprotein Cholesterol (HDL‐C), Docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), zeaxanthin and lutein. Summary Phenotypic, demographic, environmental, genetic and molecular risk factors can be combined in prediction models to predict disease progression, but the selection of the proper risk factors for personalised risk prediction will differ among individuals and is dependent on their current disease stage. Future prediction models should include a wider set of genetic variants to determine the genetic risk more accurately, and rare variants should be taken into account in highly affected families. In addition, adding molecular factors in prediction models may lead to preventive strategies and personalised advice.

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Section: Demographic and Environmental Risk Factorsmentioning

confidence: 99%

Risk factors for progression of age‐related macular degeneration

Heesterbeek

Lorés‐Motta

Hoyng

et al. 2020

Ophthalmic Physiologic Optic

255

224

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“…Casparis et al found no significant difference in the development of AMD between groups in the immediate cataract surgery group versus patients in the delayed surgery group 26. The authors suggested that the immediate surgery group fared better with quality of life outcomes than the delayed surgery group;26 however, even in patients with AMD, where central vision is lost, the peripheral visual field necessary for confident navigation can be improved by cataract surgery, and can improve quality of life for very elderly patients.…”

Section: Discussionmentioning

confidence: 97%

“…The authors suggested that the immediate surgery group fared better with quality of life outcomes than the delayed surgery group;26 however, even in patients with AMD, where central vision is lost, the peripheral visual field necessary for confident navigation can be improved by cataract surgery, and can improve quality of life for very elderly patients. In a series of studies, it was found that reduced contrast sensitivity and visual field size, rather than VA, were more strongly associated with falls and fractures in elderly people 27,28.…”

Section: Discussionmentioning

confidence: 99%

Results of cataract surgery in the very elderly population

Michalska-Małecka¹,

Nowak²,

Gościniewicz³

et al. 2013

CIA

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AimThe aim of our study was to retrospectively evaluate the effectiveness and safety of cataract surgery and intraocular lens implantation (IOL) for patients aged 90 years or older, whom we define as “very elderly.”MethodsThe study involved a total number of 122 patients (122 eyes) with senile cataracts. The mean age of patients was 91.2 ± 2.3 years (range 90–100 years old). Phacoemulsification (phaco) was done on 113 of 122 eyes, and 9 of 122 eyes had extracapsular cataract extraction (ECCE). Postoperative visual acuity and intraocular pressure (IOP) were analyzed on the first postoperative day, 3 months after surgery, and 6 months after surgery.ResultsBest corrected visual acuity (BCVA) improved in 100 of 122 eyes (82.0%). BCVA remained the same in 20 of 122 eyes (16.4%) and decreased in 2 of 122 eyes (1.6%), mainly because of coexisting age-related macular degeneration (AMD). The BCVA 3 months after surgery was ≥0.8 in 23 of 122 eyes (18.9%), between 0.5 and 0.7 in 28 of 122 eyes (22.3%), and between 0.2 and 0.4 in 33 of 122 eyes (27.1%). We found significant implications of cataract surgery on decreasing IOP in the studied group of patients suffering from glaucoma compared to the patients without glaucoma.ConclusionAdvanced age is not a contraindication for cataract surgery. The results of the study showed that when systemic conditions are stable, both phaco and ECCE with IOL for very elderly patients are effective and safe.

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“…It is becoming increasingly common throughout the world. A combination of new developments in surgical technique and technology, changes in hospital resources allocations and patient demands for quicker, more effective treatments have placed day surgery at the forefront of modern patient management (Casparis et al, 2012& Zhuang et al, 2018. Day surgery of cataract is more costeffective and efficient than inpatient surgery with equivalent clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Preparation Package: Improving Patients' Awareness and Satisfaction with Day Case Cataract Surgery

Khalil

Elderiny

Ibrahem³

et al. 2018

Egyptian Journal of Health Care

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Aim: This study aimed to evaluate the effect of multimodal preparation package on improving patients` awareness and satisfaction with day case cataract surgery. Subjects and Method: A quasi-experimental design was utilized for the conduction of this study in the Ophthalmic Outpatients` Clinics and Surgical Waiting Room of the Ophthalmic Unit, at Ain Shams University and Specialized Hospitals. A purposive sample composed of 60 patients undergoing cataract surgery, adults and old age, from both genders and were recruited from the above mentioned settings. Tools: 1) Patients' interviewing questionnaire (pre / post tests), to determine the knowledge regarding day case cataract surgery, 2) An observation checklist (pre / post tests), to evaluate studied patients' practices in relation to day case cataract surgery (pre / post tests), 3) Patients' anxiety concerns pre surgery (pre test), 4) Patients` satisfaction assessment sheet (post test), to assess the satisfaction level and 5) Patients` health condition assessment sheet (post and follow up tests). Results: More than two fifths of the studied patients were females, married and smoke. Moreover, they had anxiety concerns pre surgery added to their awareness level (knowledge and practices) were unsatisfactory in pre test. Conclusion: The current study concluded that, multimodal preparation package had a positive effect on improving awareness (knowledge and practices) and satisfaction among patients with day case cataract surgery, whereas significant improvement was found in post assessment. In addition, patients` health condition assessment was satisfactory in post and followup tests, added to its positive relation with their awareness. Recommendations: Further studies should be carried out on a large number of patients with day case cataract surgery for evidence of results and generalization.

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Surgery for cataracts in people with age-related macular degeneration

Cited by 33 publications

References 54 publications

Risk factors for progression of age‐related macular degeneration

Risk factors for progression of age‐related macular degeneration

Results of cataract surgery in the very elderly population

Multimodal Preparation Package: Improving Patients' Awareness and Satisfaction with Day Case Cataract Surgery

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