Surgery for Mycobacterium avium complex lung disease in the clarithromycin era

Shiraishi, Yuji; Nakajima, Yutsuki; Takasuna, Keiichiro; Hanaoka, Takaomi; Katsuragi, Naoya; Konno, Hidehiro

doi:10.1016/s1010-7940(01)01122-8

Cited by 68 publications

(40 citation statements)

References 15 publications

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“…Results of surgery vary; however, in the macrolide era, morbidity and mortality have generally decreased compared to those associated with premacrolide surgeries (349,350). In the premacrolide era, Corpe (82) reported a 7% perioperative mortality rate with a rate of significant postoperative complications of 18% for the surviving patients from a series of 131 patients before macrolides were available.…”

Section: Surgerymentioning

confidence: 99%

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Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

2012

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SUMMARY Within the past 10 years, treatment and diagnostic guidelines for nontuberculous mycobacteria have been recommended by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). Moreover, the Clinical and Laboratory Standards Institute (CLSI) has published and recently (in 2011) updated recommendations including suggested antimicrobial and susceptibility breakpoints. The CLSI has also recommended the broth microdilution method as the gold standard for laboratories performing antimicrobial susceptibility testing of nontuberculous mycobacteria. This article reviews the laboratory, diagnostic, and treatment guidelines together with established and probable drug resistance mechanisms of the nontuberculous mycobacteria.

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Section: Surgerymentioning

confidence: 99%

“…Shiraishi et al (349,350) also indicated that 94% of 33 patients who underwent pulmonary resection in Japan were sputum culture negative following surgery. Those authors did, however, note two late deaths: one patient died of unknown causes 12 years after the surgery, and another died of respiratory failure 2 years postoperatively.…”

Section: Surgerymentioning

confidence: 99%

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

2012

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“…According to several reports of the recurrence rate of nontuberculous mycobacterial infection after surgery, the sputum negative conversion rate was high, at 82%-94%. 10,[19][20][21] It is commonly believed that the treatment duration includes 12 months of sputum culture negativity while on therapy, 22) and, in the present case, the patient continued to receive oral antibiotic therapy after surgery, and has been followed up carefully. Regarding surgery for M. chelonae, much is unknown, including the long-term prognosis and chemotherapy to prevent recurrence.…”

Section: )mentioning

confidence: 71%

“…[8][9][10] Since surgical treatment for the M. avium complex infection is generally effective in controlling infection, therefore, it is likely that surgical treatment for M. chelonae infection is also effective. 10,12,[19][20][21] Surgery may be useful in the following settings: i) patients with localized disease, ii) patients, in whom medical therapy is ineffective, and iii) patients who cannot tolerate medical therapy. 2,12) Pulmonary resection should be considered before the expansion of lesions in patients in whom complete resection is considered possible based on the number and extent of lesions.…”

Section: )mentioning

confidence: 99%

Pulmonary Resection for Mycobacterium Chelonae Infection

Goto

Hamaguchi

Maeshima

et al. 2012

ATCS

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Mycobacterium chelonae lung infection is rare and has long been recognized as an enigmatic infection resistant to medical therapy. Recently, we encountered a patient who underwent pulmonary resection for Mycobacterium chelonae infection. A 46-year-old man with no medical history was found to have an abnormal shadow in the left upper lung field on chest X-ray. Computed tomography showed a nodular shadow in the left upper lobe and disseminated shadows around it. Mycobacterium chelonae was detected from cultures of the sputum, bronchial washings, bronchoscopic biopsy specimens, and gastric fluid, and pulmonary infection with Mycobacterium chelonae was diagnosed. The shadow did not decrease in size despite antibiotic treatment. Since the lesion was confined to the left upper segment, we judged that a complete resection was possible, and performed left upper division segmentectomy. After surgery, no new foci of infection were observed in the lung. No effective therapy for Mycobacterium chelonae lung infection has been established to date, and reported cases of pulmonary resection for the treatment of Mycobacterium chelonae infection are extremely rare. However, surgery should be considered in patients in whom complete resection is deemed possible.

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“…Pulmonary resection for Mycobacterium avium lung disease continues to play an important role when the disease has not been successfully treated by chemotherapy alone (1). However, the indication and the timing of pulmonary resection are still problematic, and to date there are no adequate recommendations.…”

Section: Introductionmentioning

confidence: 99%