Surgery for Primary Cardiac Tumors in Children

Padalino, Massimo A.; Vida, Vladimiro L.; Boccuzzo, Giovanna; Tonello, Marco; Sarris, George E.; Berggren, Håkan; Comas, Juan V.; Carlo, Duccio Di; Donato, Roberto M. Di; Ebels, Tjark; Hraška, Viktor; Jacobs, Jeffrey P.; Gaynor, J. William; Métras, D; Prêtre, René; Pozzi, Marco; Rubay, Jean; Sairanen, Heikki; Schreiber, Christian; Maruszewski, Bohdan; Basso, Cristina; Stellin, Giovanni

doi:10.1161/circulationaha.111.037226

Cited by 98 publications

(39 citation statements)

References 48 publications

(46 reference statements)

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“…For patients treated with surgery resection with benign tumors, they can achieve a significant higher survival of 82.70% at follow-up, much higher than those with malignant tumors. Incidence of recurrence of the series in our studies was rare (4.76%) in benign cardiac tumors, while more common in malignant ones (31.27%) which is also the leading factor influencing the mortality of patients with malignant cardiac tumors (4,20,30,31).…”

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confidence: 45%

Surgical treatment of cardiac tumors: a 5-year experience from a single cardiac center

Liang

Shen

et al. 2016

J. Thorac. Dis.

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Background: Cardiac tumors are rare but manifested with various clinical presentations and often cause unexpected symptoms or sudden death. The objective is to review the clinical presentation, histopathological spectrum, mortality and follow-up data of patients with cardiac tumors following surgery treatment over a period of 5 years. Methods:We retrospectively collected the medical records of all patients diagnosed of cardiac tumors in the period between January 2008 and December 2013 at the cardiac center of our university. Clinical histories, perioperative data, surgical findings, efficacy and follow-up data were reviewed in our study.Patients were divided into two groups according to site distribution of the tumors in the heart.Results: A total of 131 patients underwent surgical treatment of cardiac tumors were enrolled in this study, with a mean age of 51.39±16.37. The result of analysis showed that 79.47% (n=104) of the primary intracardiac tumors were benign, while primary malignant neoplasms accounted for 16.03% (n=21) of all patients, with the remainder (n=6, 4.6%) metastatic tumors transferred from other organs. Among all patients there were 2 in-hospital deaths and the survival rate in all patients at 1-year, 3-year and 5-year follow up was 83.20%, 78.62% and 66.41% respectively. Both patients with tumors in the left and right heart had similar basic characteristics except sex gender (P=0.002), BSA (P=0.045) and weight (P=0.033). Compared with patients with tumors in the right heart, patients with tumors in the left heart had significant higher CPB time (P<0.001), cross clamp time (P<0.001) and time of mechanical ventilation (P<0.001), and they also had longer ICU stay (P<0.001) but not total hospital stay (P=0.434).Conclusions: Surgical resection represents an effective protocol in treating cardiac tumors. Data in our study of cardiac tumors on frequency and allocation were consistent with previous reports which may provide useful clinical evidence on shared data, and data revealed that patients with malignant cardiac tumors had significant lower survival both in hospital and long-term follow-up.

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confidence: 45%

Surgical treatment of cardiac tumors: a 5-year experience from a single cardiac center

Liang

Shen

et al. 2016

J. Thorac. Dis.

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“…[17] The use of cardiac transplantation for any primary cardiac tumor is not recommended since there is a higher 10-year mortality rate with transplantation (25%) than resections (2.75%). [18] However, there are no studies comparing the effects of transplantation versus resection after multiple cardiac surgeries.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of multiple myxoma resections with carney complex

Siordia

Garlish

2015

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Introduction: Carney Complex is a rare multiple endocrine neoplasia with cardiac myxomas being the most common cause of death among affected patients. One must consider how many heart surgeries a patient may acquire before the treatment itself becomes a significant risk factor. The use of an intra-aortic filter during cardiac surgeries is recommended, and heart transplantation treatment for Carney Complex patients is proposed. Presentation of case: A 24-year-old female presented with lightheadedness and was found to have a cardiac myxoma on the left atrium. The patient underwent myxoma resections on four separate occasions. The patient underwent a fifth cardiac myxoma resection. However, three days post-operatively, the patient experienced right-sided hemiplegia and imaging showed 99% left carotid artery occlusion. The patient was deemed unqualified for neurosurgical intervention and the patient died 5 days post-operatively. Discussion: Cardiac surgery can become detrimental with multiple surgical resections. With increased number of cardiac surgeries and increased risk for morbidities postoperatively, Carney Complex patients should have an intra-aortic filter to lower the risk of stroke. Conclusions: Intra-aortic filter usage is recommended during surgical resection of cardiac tumors to capture emboli before they travel into the systemic circulation. Heart transplant may prove beneficial to Carney complex cases, however neither the optimal number of cardiac operations nor the timing of heart transplantation in the disease are documented in literature, limiting evidence for solid therapeutic guidelines.

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“…2012 m. publikuotos multicentrinės studijos duomenimis, 68,5 proc. operuotų pacientų pasireiškė klinikiniai simptomai [14]. Operacijos metu gali būti atliekama visiška (69,7 proc.)…”

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Klinikinė Perinatalinio Periodo Širdies Rabdomiomų Patirtis Vilniaus Perinatologijos Centre

Vankevičienė

Kinčinienė

Drejerienė

et al. 2014

Medicinos Teorija Ir Praktika

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Reikšminiai žodžiai: vaikų širdies tumorai, širdies rabdomioma, tuberozinės sklerozės kompleksas. Darbo tikslas. Išanalizuoti, įvertinti klinikinę patirtį diagnozuojant ir gydant vaisiaus ir naujagimio širdies rabdomiomas. Tyrimo medžiaga ir metodai. Išanalizuoti vaisių ir naujagimių, kuriems 1996–2013 m. laikotarpiu diagnozuotos širdies rabdomiomos, atvejai. Įvertinta antenatalinė ir postnatalinė rabdomiomų eiga, stebėjimo ir gydymo galimybės, rabdomiomų ryšys su tuberozine skleroze. Rezultatai. Širdies rabdomiomos – ypač reta patologija. Per 23 metus perinataliniame periode diagnozuoti tik 7 širdies rabdomiomų atvejai. Tik vienam vaisiui buvo prenatalinės hemodinamikos sutrikimai ir išsivystė vaisiaus vandenė, po gimimo penkiems naujagimiams pastebėti klinikiniai simptomai (aritmijos – prieširdinės ir skilvelinės ekstrasistolės, kliūtis kraujui nutekėti iš dešiniojo ir kairiojo skilvelių). Stebint vaikus vėliau, tuberozinės sklerozės kompleksas patvirtintas trims pacientams. Vienas naujagimis sėkmingai po gimimo operuotas. Išvados. Širdies rabdomiomos vaisiui ir naujagimiui dažniausiai yra gerybinės ir nesukelia širdies-kraujagyslių sistemos pokyčių. Tuberozinė sklerozė diagnozuojama dauguma širdies rabdomiomų atvejų.

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Surgery for Primary Cardiac Tumors in Children

Abstract: Background-To

Cited by 98 publications

References 48 publications

Surgical treatment of cardiac tumors: a 5-year experience from a single cardiac center

Surgical treatment of cardiac tumors: a 5-year experience from a single cardiac center

Outcomes of multiple myxoma resections with carney complex

Klinikinė Perinatalinio Periodo Širdies Rabdomiomų Patirtis Vilniaus Perinatologijos Centre

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