Surgical adhesive BioGlue™ does not benefit tendon repair strength: an ex vivo study

Jordan, Martin; Schmitt, Verena; Dannigkeit, S.; Schmidt, Karsten; Meffert, Rainer H.; Hoelscher-Doht, Stefanie

doi:10.1177/1753193414566566

Cited by 10 publications

(7 citation statements)

References 30 publications

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“…However, investigators continue to explore different methods, which include the use of bio-glue, barbed sutures, vein grafts, etc., to further enhance repair performance by attempting to improve gap forces, minimize repair bulk, etc. (Jordan et al, 2015; Joyce et al, 2014; Peltz et al, 2014; Rodger et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Biomechanical investigation of ‘figure of 8’ flexor tendon repair techniques

Agrawal

Jais

Chew

et al. 2016

J Hand Surg Eur Vol

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This biomechanical study compared the original Al-Qattan repair with other modifications postulated to reduce bulk and friction, thereby potentially improving outcome. A total of 32 cadaveric digits with intact flexor apparatus were used. In each digit, the flexor digitorum profundus and flexor digitorum superficialis tendons were cut cleanly in Zone 2. We tested Al-Qattan's technique along with three modifications using stronger suture material and varying the number of strands across the repair site. Of the four repair techniques, the modified Al-Qattan's technique using two 'figure of 8' 4-0 Fiberwire core sutures (Group 4) had the best balance of ultimate tensile strength (50.9 N), 2 mm gapping force (38 N) and friction. The modified technique provided a stronger repair for early active mobilization and has less friction than the originally described repair.

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Section: Discussionmentioning

confidence: 99%

Biomechanical investigation of ‘figure of 8’ flexor tendon repair techniques

Agrawal

Jais

Chew

et al. 2016

J Hand Surg Eur Vol

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“…Wrapping repaired tendons with bioadhesive film increased tensile stiffness, failure load, and energy to failure in comparison with suture alone group [131]. In contrast, ex vivo application of bioadhesives (BioGlue ® ) on suture repaired flexor tendons failed to improve tensile properties [130]. When bioadhesives were applied to sutures instead of tendons, repaired tendons with bioadhesives-coated sutures increased the tensile properties of repaired tendon likely attributed to shear lag effect [132].…”

Section: Tendonmentioning

confidence: 98%

“…The primary treatment option for tendon rupture is suture-repair, and various suture techniques are being implemented depending on types of tendon and injuries. Unfortunately, the rate of tendon re-rupture is high because repaired tendons hardly recover the original mechanical strength [130]. Few bioadhesive materials have been investigated to enhance the success rate of suture-repair, consequently reducing the re-tear rate [90].…”

Section: Tendonmentioning

confidence: 99%

Bioadhesives for musculoskeletal tissue regeneration

Tarafder¹,

Park²,

Felix³

et al. 2020

Acta Biomaterialia

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“…Mounting evidence shows the benefits of tissue adhesives alone or as an ancillary method to suturing, but the healing outcomes remain limited. [ 347,348 ] A reason for the unsatisfactory results is the mechanical mismatch between the implantable adhesives and the target tissues. For instance, fibrin glues used in previous studies were much softer and more brittle than the musculoskeletal tissues.…”

Section: Emerging Applications Of Tissue Adhesivesmentioning

confidence: 99%

“…[ 10 ] Due to the lack of mechanical strength, commercialized tissue adhesives such as fibrin glues and Bioglue suffer from limited outcomes in repairing tendon. [ 347,348 ] The mismatch of mechanical properties is a major constraint that disqualifies tissue adhesives as a stand‐alone repair technique to replace suturing. Another mechanical concern is about the loss of adhesion under cyclic loading, i.e., interfacial fatigue fracture.…”

Section: Future Directionsmentioning

confidence: 99%

Multifaceted Design and Emerging Applications of Tissue Adhesives

2021

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Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in a variety of medical settings such as wound closure, surgical sealants, regenerative medicine, and device attachment. The advantages of tissue adhesives include ease of implementation, rapid application, mitigation of tissue damage, and compatibility with minimally invasive procedures. The field of tissue adhesives is rapidly evolving, leading to tissue adhesives with superior mechanical properties and advanced functionality. Such adhesives enable new applications ranging from mobile health to cancer treatment. To provide guidelines for the rational design of tissue adhesives, here, existing strategies for tissue adhesives are synthesized into a multifaceted design, which comprises three design elements: the tissue, the adhesive surface, and the adhesive matrix. The mechanical, chemical, and biological considerations associated with each design element are reviewed. Throughout the report, the limitations of existing tissue adhesives and immediate opportunities for improvement are discussed. The recent progress of tissue adhesives in topical and implantable applications is highlighted, and then future directions toward next‐generation tissue adhesives are outlined. The development of tissue adhesives will fuse disciplines and make broad impacts in engineering and medicine.

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Surgical adhesive BioGlue™ does not benefit tendon repair strength: an ex vivo study

Abstract: n/a.

Cited by 10 publications

References 30 publications

Biomechanical investigation of ‘figure of 8’ flexor tendon repair techniques

Biomechanical investigation of ‘figure of 8’ flexor tendon repair techniques

Bioadhesives for musculoskeletal tissue regeneration

Multifaceted Design and Emerging Applications of Tissue Adhesives

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