Surgical alternatives in the treatment of polyposis coli

Abstract

The history of familial polyposis coli and its various surgical treatment alternatives are presented. Each form of treatment has advantages and disadvantages. The menu of alternatives allows the surgeon the freedom to choose the best option for each patient.

The UK Northern region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium, and DNA markers in risk calculations.

“…As a conservative figure for the purpose of risk calculation, it was assumed that a count of less than four small lesions represented a conditional probability of 1 in 10 of being a gene carrier. The overall distribution of eye signs (fig 3) in the 141 polyp free relatives at risk reinforces the belief that most adults considered at risk are not, in fact, carriers of the gene. Table 1 shows the distribution of gene carriers according to the presence or absence of typical Table 1 Analysis ofsensitivity ofophthalmological screening based on total number ofCHRPEs in column 1, taking account of'typical' hypolhyperpigmented or large lesuns in column 2, and making allowancefor the presence ofeye signs in relatives in column 3.…”

Pouch adenocarcinoma after restorative proctocolectomy for familial adenomatous polyposis

“…Dear sir , Familial adenomatous polyposis (FAP) is an hereditary autosomal dominant disease that inevitably leads to colorectal cancer when prophylactic surgery is not performed [1].…”