Surgical Approach to Bone Metastases

Siegel, Geoffrey; Biermann, J. Sybil; Calinescu, Anda-Alexandra; Spratt, Daniel E.; Szerlip, Nicholas

doi:10.1007/s11914-018-0463-7

Cited by 15 publications

(10 citation statements)

References 42 publications

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“…The advent of computer-aided surgical navigation systems helped greatly in reducing radiation exposure, but many hospitals have yet to equip them because of their high cost. Siegel et al [2018] (25) found that the radiation time during percutaneous pedicle screw fixation was longer than in the conventional open surgery group. The effective dose in the transcutaneous group was more than three times that in the open group.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of the effect of using percutaneous pedicle screw internal fixation for thoracolumbar fractures

Lu¹,

Chen²,

Hu³

et al. 2022

Ann Palliat Med

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Background: Thoracolumbar fractures are common in routine injuries. The best way to treat a thoracolumbar fracture is to repair the thoracic fracture with fixation, which is classified into percutaneous pedicle screw fixation and open pedicle screw fixation. Methods:The literature was searched in the English database PubMed, Ovid-Medline, Embase, and China Biology Medicine Disc (CBM) from the date of establishment of PubMed to June 2021, and keywords such as percutaneous pedicle screw and posterior percutaneous pedicle screw fixation were searched. A metaanalysis was performed using RevMan5.3, which was provided by Cochrane.com.Results: A total of 9 articles were included. The results showed that the operative time of percutaneous pedicle screw fixation was shorter than that of open pedicle screw fixation. Percutaneous pedicle screw internal fixation had better Cobb angle restoration effect than open pedicle screw internal fixation. However, there were considerable differences in pain and screw misplacement rates. In addition, the pain after percutaneous pedicle screw fixation was smaller than that after open pedicle screw fixation, and patients had better compliance. Discussion: Compared with open surgery, percutaneous pedicle screw fixation had a shorter operation time, better cobb angle recovery, and a lower pain sensation following surgery. The low rate of screw misplacement and postoperative infection suggested that percutaneous pedicle screw fixation was more effective than open surgery.

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Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of the effect of using percutaneous pedicle screw internal fixation for thoracolumbar fractures

Lu¹,

Chen²,

Hu³

et al. 2022

Ann Palliat Med

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“…Dose fractionation schedules included multi-fraction radiation, such as 30 Gy in ten fractions. Adjuvant therapy-like radiation [19] was used after surgery or POP to prevent tumor recurrence.…”

Section: Management Algorithmmentioning

confidence: 99%

Machine Learning Algorithm Guiding Local Treatment Decisions to Reduce Pain for Lung Cancer Patients with Bone Metastases, a Prospective Cohort Study

Wang

Sun

et al. 2021

Pain Ther

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Introduction: As life expectancy increases for lung cancer patients with bone metastases, the need for personalized local treatment to reduce pain is expanding. Methods: Patients were treated by a multidisciplinary team (MDT), and local treatment including surgery, percutaneous osteoplasty, or radiation. Visual analog scale (VAS) and quality of life (QoL) scores were analyzed. VAS at 12 weeks after treatment was the main outcome. We developed and tested machine learning models to predict which patients should receive local treatment. Model discrimination was evaluated by the area under curve (AUC), and the best model was used for prospective decision-making accuracy validation. Results: Under the direction of MDT, 161 patients in the training set, 32 patients in the test set, and 36 patients in the validation set underwent local treatment. VAS in surgery, percutaneous osteoplasty, and radiation groups decreased significantly to 4.78 ± 1.28, 4.37 ± 1.36, and 5.39 ± 1.31 at 12 weeks, respectively (p \ 0.05), with no significant differences among the three datasets, and improved QoL was also observed (p \ 0.05). A decision tree (DT) model that included VAS, bone metastases character, Frankel classification, Mirels score, age, driver gene, aldehyde dehydrogenase 2, and enolase 1 expression had a best AUC in predicting whether patients would receive local treatment of 0.92 (95% CI 0.89-0.94) in the training set, 0.85 (95% CI 0.77-0.94) in the test set, and 0.88 (95% CI 0.81-0.96) in the validation set. Conclusion: Local treatment provided significant pain relief and improved QoL. There were no significant differences in reducing pain and improving QoL among training, test, and validation sets. The DT model was best at

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“…Readily available morphology-based scoring tools for predicting pathologic long bone fracture have limited accuracy [35] , [36] . Nonetheless, a review by Siegel et al points out that the presence of pain with weight bearing is likely the most important factor in determining risk for pathologic fracture [37] . Extent of cortical involvement and osteolytic lesions have also been shown to be associated with higher risk of pathologic fracture [38] , [39] .…”

Section: Resultsmentioning

confidence: 99%

Multidisciplinary Treatment of Non-Spine Bone Metastases: Results of a Modified Delphi Consensus Process

Gillespie

Mathis

Vaynrub

et al. 2022

Clinical and Translational Radiation Oncology

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Surgical Approach to Bone Metastases

Cited by 15 publications

References 42 publications

Systematic review and meta-analysis of the effect of using percutaneous pedicle screw internal fixation for thoracolumbar fractures

Systematic review and meta-analysis of the effect of using percutaneous pedicle screw internal fixation for thoracolumbar fractures

Machine Learning Algorithm Guiding Local Treatment Decisions to Reduce Pain for Lung Cancer Patients with Bone Metastases, a Prospective Cohort Study

Multidisciplinary Treatment of Non-Spine Bone Metastases: Results of a Modified Delphi Consensus Process

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