Surgical approach to the management of Brucella endocarditis

Abstract

We concluded that medical and surgical treatment had to be performed simultaneously for the successful management of Brucella endocarditis, a fatal complication of Brucella infection.

Management of Brucella endocarditis: results of the Gulhane study

“…There was no significant difference in antibiotic duration between patients exposed to surgery and those treated with antibiotics alone, and the former group of patients was given treatment for an additional 1 month on average after surgery. At this point, controversy seems to exist on the duration of antibiotics in the literature and there are case series recommending an additional 6 months of therapy following surgery [21]. However, the current data disclose a more conservative approach for antibiotic treatment in the post-surgical period.…”

“…Rarely, embolism of the coronary ostium can cause acute myocardial infarction and subsequent heart failure [29]. On the other hand, pericardial effusion leading to cardiac tamponade has been reported in a BE case in the literature [21]. Thus, pericardial effusion and heart failure were independent risk factors for mortality in this study.…”

Pediatric brucellosis

“… 33 There were many rare complications of brucellosis that have been described in children such as cardiac complications such as endocarditis and myocarditis. 34 Neurobrucellosis is also a rare complication which can be detected in 2–7% of child cases. The most common clinical forms of neurobrucellosis are meningitis, encephalitis, and myelitis while brain abscesses are extremely rare.…”

A case of brucellosis complicated with fatal capillary leak syndrome

“…In fact, Brucella lipopolysaccharide is reported to act as a virulence factor of the infection (8). In a number of trials carried out in patients with brucellosis, IFN-γ, neopterin, IL-2-6-8-12 and TNF alfa were found to be signifi cantly higher than in the control group (14). It seems that these cytokins play a role in the development of CLS syndrome, DIC and certain haematological disorders.…”