for Neurological and Psychiatric Disorders of NCNP.The authors declare that there are no conflicts of interest.MiM drafted the manuscript and participated in the design of the study. MaM conceived this study and revised the manuscript. WS, TI, and GI participated in its design and coordination and drafted the manuscript. ES, KU, and TA helped to revise the manuscript and carried out statistical analysis. NT and MT conceived the study and participated in its design and coordination. All the authors have read and have approved the final manuscript.Ethical approval from Institutional Review Board in Kitasato University was obtained for this study, which was conducted in accordance with the ethical principles specified in the 1964 Declaration of Helsinki and its later amendments.The approval code is #B16-236. Results: There were 5 (6%) major complications, including pneumonia and a cardiovascular complication requiring intensive care unit (ICU) care, and 15 (18%) minor complications including viral enteritis and a urinary tract infection.Overall, there were 20 (24%) complications. Three of the 5 major complications were pulmonary. The mean age at the time of surgery was 13.7 y, operative time was 304 min, and blood loss was 1530 ml. The mean preoperative %VC was 41%, FEV 1.0 was 91%, and EF was 60%. When we separated the patients into a group with major complications (n = 5) and a group without major complications (n = 78), the preoperative %VC in the group with major complications (23%) was significantly lower than that in the group without (42%) (p < 0.05). However, operative time, blood loss, preoperative FEV 1.0 (%) and EF between the two groups were not significantly different (p > 0.05).
Conclusion:Compared with the previous findings of the perioperative complication rate (45%-74%) for NMS, the complication rate was remarkably low in this case series. Because of advances in medical skills, including anesthesia and surgical instruments, surgery for NMS appears to be safe.However, patients with NMS with complications demonstrated severe restrictive ventilatory impairment preoperatively. Therefore, we should be vigilant for perioperative pulmonary complications especially in patients with NMS and preoperative severe restrictive ventilatory impairment.