Surgical extraction of subfoveal choroidal new vessels and submacular haemorrhage in age-related macular degeneration: results of a prospective study

Abstract

Subfoveal surgery might preserve remaining retinal function in eyes with well-defined CNV. However, subgroups of the MPS subfoveal laser trials with comparable initial visual acuity demonstrated postoperative functional stabilisation and similar recurrence rates in well-defined CNV. Though selected cases of submacular haemorrhage did profit from surgery, TPA-assisted gas injection will probably be a better alternative. Unfortunately, surgery for ill-defined CNV, found in the vast majority of eyes with exudative ARMD, seems to worsen the natural course. Surgery has to be combined with restoration of Bruch's membrane before it can become a possible therapeutic option in ARMD.

Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration — long term results

“…Again, comparability is limited as the size of the CNV was limited to 9 disc areas including the laser scar in the SST study. Considering that the subfoveal portion was a recurrence of juxta-or extrafoveal CNV the final shortest distance of the recurrent CNV between its outer margin to the fovea might have been smaller than with [14,23,29].…”

In-patient management and treatment satisfaction after intravitreous plasminogen activator injection

“…It is relevant to state that all patients in this study were provided with adequate information and given the choice for alternative treatment strategies [29,33], but they choose plasminogen activator injection as the preferred option for treatment of subretinal hemorrhage. To our knowledge, however, no other ophthalmic literature exists on treatment satisfaction with plasminogen activator injection, and we therefore have no other data to compare our results with.…”

“…Although advances in vitreoretinal surgery have made the subretinal removal of blood possible, these surgical interventions are often difficult and potentially harmful to the overlying retina and retinal pigment epithelium cells [17,29,33]. With the introduction of plasminogen activator injections vision was reported to improve in most patients with subretinal hemorrhages due to AMD [13,22,32].The method of r-TPA and gas injection allows a liquification and displacement of the blood out of the macular area when a face-down position is kept.…”

Autologous translocation of the choroid and RPE in age-related macular degeneration: 1-year follow-up in 30 patients and recommendations for patient selection

“…It is known that surgical extraction of the choroidal neovascularization (CNV) in these patients is technically feasible; 4,5 however, it did not improve nor preserve visual acuity (VA) over 24 months in randomized trials. 6 Peyman first suggested translocation of peripheral choroid and retinal pigment epithelium (RPE) in order to supplement transplanted pigment epithelium with the underlaying intact Bruch's membrane and choroid.…”