Surgical interventions for the treatment of radiation‐induced alopecia in pediatric practice

Rannan‐Eliya, Yi Fan; Rannan-Eliya, Sahan V.; Graham, Kenneth E.; Pizer, Barry; McDowell, Heather P.

doi:10.1002/pbc.20689

Cited by 18 publications

(9 citation statements)

References 31 publications

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“…Investigation cost and medicine cost was found to be the biggest source of OOP expenditure, 44.13% and 36.91% respectively. These results are supported by previous studies on OOP expenditure, where cost for investigation and medicine were shown to be the most responsible for high OOP expenditure 24,[29][30][31][32] . Moreover, cost for investigations is considerably high in Bangladesh 33 , which also contributed to the high OOP expenditure for our study population.…”

Section: Discussionsupporting

confidence: 88%

Out-of-Pocket Expenditure of the Hospitalized Patients for Treatment of Liver Cirrhosis in a Tertiary Hopspital

Haque

Islam

Akter³

et al. 2021

JOPSOM

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Background: Out-of-pocket expenditure is the major financer for health care expenses in Bangladesh, causing financial burden on affected households. Chronic disease like liver cirrhosis requires long term treatment, exposing households to further economic stress, pushing them into a state where they fail to meet the necessary health expenses from their own household consumption and sacrifices basic necessities of living to pay for healthcare services. This study aims to estimate the OOP expenditure and resulting catastrophic health expenditure among hospitalized patients of liver cirrhosis. Methods: This was a cross-sectional study conducted among 42 diagnosed liver cirrhosis patients admitted at Bangabandhu Sheikh Mujib Medical University (BSMMU) under the department of hepatology and department of gastroenterology, aged 18 years and above. Convenient sampling technique was used and data were collected from the respondents using a semi-structured questionnaire through face-to-face interview during discharge from hospital. Results: Out of pocket expenditure for liver cirrhosis at BSMMU was BDT 24,898. Direct medical cost was BDT 21,202, direct non-medical cost was BDT 1,895 and indirect cost was BDT 1,801. Among the determinants of OOP healthcare expenditure, medicine and investigation costs were the major cost drivers, 36.91% and 44.13% of the total expenditure, respectively. OOP expenditure was found to be slightly higher among respondents from department of hepatology, than department of gastroenterology, BDT 21,834 and BDT 18,043 respectively, but this difference was not statistically significant. At 10% threshold level, 40.5% of the respondents were affected by Catastrophic Healthcare Expenditure (CHE). Nearly one-third (30.9%) of the respondents were facing distress financing due to OOP Expenditure. Conclusions: The high amount of OOP expenditure can be contributed mostly to the high cost of medicine and investigation. Making medicine readily available at an affordable price along with rational use of medication and investigation for diagnostic purpose can help reduce this financial burden on affected households. JOPSOM 2020; 39(2): 74-82

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Section: Discussionsupporting

confidence: 88%

Out-of-Pocket Expenditure of the Hospitalized Patients for Treatment of Liver Cirrhosis in a Tertiary Hopspital

Haque

Islam

Akter³

et al. 2021

JOPSOM

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“…38,39 Persistent radiotherapy-induced alopecia (pRIA) is the total or incomplete hair regrowth 6 months following radiotherapy completion, and is commonly related to highdose radiotherapy to the scalp. 40 In 26 patients with primary brain tumors, the doses reported to cause pRIA were correlated with radiotherapy dose to the hair follicles in a particular radiotherapy field, with a 50% risk for pRIA with a fractionated follicular dose of ≥ 43 Gy. 41 In 12 children with medulloblastoma treated with proton beam radiation in combination with high dose vincristine-based chemotherapy, pRIA was observed in 75%, and was correlated with a craniospinal radiotherapy dose above 21 Gy.…”

Section: Persistent Chemotherapy-induced Alopeciamentioning

confidence: 99%

“…96 Multiple scalp reconstructive options have been described to improve the appearance of the localized pRIA, including tissue expansion, and hair transplantation. 40 However, the success of these techniques will rely on the skin viability and severity of hair follicle damaged. 97 There is no reported experience using platelet-rich plasma to treat alopecias in cancer survivors, and costs may be elevated.…”

Section: Management Key Pointmentioning

confidence: 99%

Hair disorders in cancer survivors

Freites-Martínez

Shapiro

Hurk

et al. 2019

Journal of the American Academy of Dermatology

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With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, post-surgery alopecia and localized hypertrichosis, alopecia attributed to therapeutic transplants, and to novel anticancer therapies. The information contained in this continuing medical education article should facilitate a better understanding on hair disorders in cancer survivors, so that adequate support and therapies may be provided to cancer survivors.

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“…This technique could be extended to other ANIAs when the donor area is sufficient and when alopecia is considered stable. Finally, a skin expansion (by placing prostheses under the scalp and followed by plastic surgery) could be a promising surgical technique for pRIA/pCIA [ 72 ].…”

Section: Alopecia Managementmentioning

confidence: 99%

Cancer-Related Alopecia: From Etiologies to Global Management

Quesada

Guichard²,

Fiteni

2021

Cancers

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Alopecia represents a multifaceted challenge with distinct etiologies and consequences. Transposed to the world of oncology, different types of alopecia and molecular pathways have been characterized, allowing a better understanding of the underlying mechanisms. In patients with cancer, alopecia can be iatrogenic (i.e., due to conventional chemotherapies, endocrine therapies, targeted therapies, immunotherapies, radiotherapy and surgery) or a direct consequence of the disease itself (e.g., malnutrition, scalp metastases and paraneoplastic syndromes). Identification of the actual incriminated mechanism(s) is therefore essential in order to deliver appropriate supportive care, whether preventive or curative. On the preventive side, the last few years have seen the advent of the automated cooling cap, a prophylactic approach supported by several randomized clinical trials. On the curative side, although the treatments currently available are limited, several promising therapeutic approaches are under development. Appropriate alopecia management is essential, particularly regarding its psychological repercussions with significant consequences on the quality of life of patients and their family and with a potential impact on treatment compliance.

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Surgical interventions for the treatment of radiation‐induced alopecia in pediatric practice

Cited by 18 publications

References 31 publications

Out-of-Pocket Expenditure of the Hospitalized Patients for Treatment of Liver Cirrhosis in a Tertiary Hopspital

Out-of-Pocket Expenditure of the Hospitalized Patients for Treatment of Liver Cirrhosis in a Tertiary Hopspital

Hair disorders in cancer survivors

Cancer-Related Alopecia: From Etiologies to Global Management

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