Surgical Management of Neuroendocrine Tumors of the Appendix in Children and Adolescents: A Retrospective French Multicenter Study of 114 Cases

Lambert, Guénolée de; Lardy, H.; Martelli, Hélène; Orbach, Daniel; Gauthier, F.; Guérin, Florent

doi:10.1002/pbc.25823

Cited by 54 publications

(84 citation statements)

References 26 publications

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“…No survival advantage was therefore conferred by another procedure. This confirms the observations of several authors …”

Section: Discussionsupporting

confidence: 93%

“…Several pediatric studies have questioned the use of these guidelines in children and the benefit of more extensive procedures like RHC following the incidental histological diagnosis of an appendiceal carcinoid …”

Section: Discussionmentioning

confidence: 99%

“…Lambert et al. in the French study of 2016, identified 29 pediatric patients with criteria for a secondary procedure . Ten of these had an RHC.…”

Section: Discussionmentioning

confidence: 99%

“…15 Several pediatric studies have questioned the use of these guidelines in children and the benefit of more extensive procedures like RHC following the incidental histological diagnosis of an appendiceal carcinoid. 2,6,8,9,16 Carcinoid syndrome from an appendiceal carcinoid has not been described in children. 12,17 In this study, flushing episodes were present in 12 children (1.2%) and were accompanied by diarrhoea in 2.…”

Section: Discussionmentioning

confidence: 99%

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Systematic review and meta‐analysis of appendiceal carcinoid tumors in children

Njere

Smith

Thurairasa

et al. 2018

Pediatric Blood & Cancer

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“…No survival advantage was therefore conferred by another procedure. This confirms the observations of several authors …”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…Lambert et al. in the French study of 2016, identified 29 pediatric patients with criteria for a secondary procedure . Ten of these had an RHC.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review and meta‐analysis of appendiceal carcinoid tumors in children

Njere

Smith

Thurairasa

et al. 2018

Pediatric Blood & Cancer

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“…Ciarrocchi et al [25] utilised a propensity score model and showed that simple appendectomy was not inferior to RH regarding survival in patients with ANEN >2 cm. In the analysis of 114 cases of paediatric ANEN by de Lambert et al [26], 10 patients had tumours >2 cm and 20 patients had extension into the mesoappendix, including 5 with lympho-/vascular invasion. Ten of 29 cases with indications for hemicolectomy underwent further resection; however, no specimens demonstrated evidence of residual disease.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Patients with Neuroendocrine Neoplasms of the Appendix: Appendectomy or More

et al. 2017

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Background: Appendiceal neuroendocrine neoplasms (ANEN) are mostly indolent tumours treated effectively with simple appendectomy. However, controversy exists regarding the necessity of oncologic right hemicolectomy (RH) in patients with histologic features suggestive of more aggressive disease. We assess the effects of current guidelines in selecting the surgical strategy (appendectomy or RH) for the management of ANEN. Methods/Aims: This is a retrospective review of all ANEN cases treated over a 14-year period at 3 referral centres and their management according to consensus guidelines of the European and the North American Neuroendocrine Tumor Societies (ENETS and NANETS, respectively). The operation performed, the tumour stage and grade, the extent of residual disease, and the follow-up outcomes were evaluated. Results: Of 14,850 patients who had appendectomies, 215 (1.45%) had histologically confirmed ANEN. Four patients had synchronous non-ANEN malignancies. One hundred and ninety-three patients had index appendectomy. Seventeen patients (7.9%) had lymph node metastases within the mesoappendix. Forty-nine patients underwent RH after appendectomy. The percentages of 30-day morbidity and mortality after RH were 2 and 0%, respectively. Twelve patients (24.5%) receiving completion RH were found to have lymph node metastases. Two patients had liver metastases, both of them synchronous. The median follow-up was 38.5 months (range 1-143). No patient developed disease recurrence. Five- and 10-year overall survival for all patients with ANEN as the only malignancy was both 99.05%. Conclusions: The current guidelines appear effective in identifying ANEN patients at risk of harbouring nodal disease, but they question the oncological relevance of ANEN lymph node metastases. RH might present an overtreatment for a number of patients with ANEN.

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