Surgical management of retroperitoneal sarcoma and opportunities for global collaboration

Wang, Jennifer; Grignol, Valerie; Gronchi, Alessandro; Luo, Cheng Hua; Pollock, Raphael E.; Tseng, William W.

doi:10.21037/cco.2018.07.05

Cited by 28 publications

(41 citation statements)

References 46 publications

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“…When no obvious lymph node metastasis is observed, dissection is not recommended . In contrast, complete resection has been reported to contribute to convalescence in patients with advanced or recurrent disease who have extra‐uterine extension . The efficacy of radiotherapy in ULMS has been reported to be limited, and the efficacy of adjuvant radiotherapy for patients with early‐stage ULMS remains unclear …”

Section: Introductionmentioning

confidence: 99%

“…7 The primary treatment for ULMS is surgery, with the goal of complete resection. 8 Whether oophorectomy should be performed is controversial, because oophorectomy had not been shown to be associated with improved survival. The rate of metastasis to adnexa in patients with early-stage ULMS is approximately 3%.…”

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confidence: 99%

“…10 In contrast, complete resection has been reported to contribute to convalescence in patients with advanced or recurrent disease who have extra-uterine extension. 8,11 The efficacy of radiotherapy in ULMS has been reported to be limited, and the efficacy of adjuvant radiotherapy for patients with early-stage ULMS remains unclear. 12 Adjuvant chemotherapy (ACT) has been administered with the intent of improving the prognosis of patients with ULMS, but 50-70% of patients experience recurrence, including those with early-stage disease confined to the uterus.…”

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confidence: 99%

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Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10‐year experience of a single institute

Kodama

Sonoda

Kijima

et al. 2019

Asia-Pac J Clncl Oncology

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Aim Uterine leiomyosarcoma (ULMS) is a highly aggressive and lethal disease. This malignancy remains the most common type of uterine sarcoma, affecting approximately 0.4/100 000 women each year. Our aim was to assess the treatment and prognosis of ULMS patients. Methods A total of 14 patients were treated at our institution between January 2008 and July 2017. We retrospectively analyzed their clinicopathological variables, treatment and prognosis. Results The median patient age was 63 years (range, 35–83 years). The largest group of patients had stage IB disease (stage IB, n = 8; IIB, n = 2; IIIB, n = 1; IVB, n = 3) and the largest group by histological subtype was ordinary (ordinary, n = 11; myxoid, n = 2; epithelioid, n = 1). Total abdominal hysterectomy and bilateral salpingo‐oophorectomy were performed for all patients, with additional surgical procedures (e.g., tumor resection, lymphadenectomy) performed if necessary. Twelve patients received adjuvant chemotherapy (ACT) consisting of gemcitabine and docetaxel. Ten patients experienced recurrence and received multidisciplinary therapies, including tumor resection, chemotherapy, radiation and targeted therapies. The median observation period was 17 months (range, 5–75 months), and 11 patients were alive (without disease, n = 5; with disease, n = 6). Intriguingly, five of eight stage IB patients who received postoperative ACT were alive without disease. Conclusion ULMS is rare but is associated with a poor prognosis, even if multidisciplinary therapies are administered. However, ACT appears to be effective in improving the prognosis of patients with stage IB disease.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10‐year experience of a single institute

Kodama

Sonoda

Kijima

et al. 2019

Asia-Pac J Clncl Oncology

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“…Retroperitoneal sarcomas (RPS) are a rare group of soft tissue malignant neoplasms that comprise merely 1%-2% of all solid cancers and only 10%-20% of all sarcomas [ 6 - 8 ]. These tumors classically arise in the retroperitoneum and have the potential to reach exorbitant proportions without eliciting any symptoms, and thus usually present late in the disease course.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Pathological Characteristics of Soft Tissue Sarcomas: A Retrospective Study From a Developing Country

Almas

Khan

Murad

et al. 2020

Cureus

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Introduction Soft tissue sarcomas remain an exceedingly rare malignancy. While soft tissue sarcomas boast a high mortality rate, their characteristics and behavior patterns are poorly understood. This study aims to evaluate the various aspects that pertain to soft tissue sarcomas, including their histology, tumor characteristics, survival rates, and therapeutic modalities. Methods A retrospective study analyzing the data from 19 patients presenting over four years with a histologically confirmed diagnosis of soft tissue sarcomas was conducted. The patients were studied for various parameters, including tumor site and the particular pathological subtypes. The data obtained were analyzed using the SPSS 23.0 statistical software (IBM Corporation, Armonk, NY), and the results were then tabulated. Results A total of 19 patients with a confirmed diagnosis of a soft tissue sarcoma were included in the study. The mean age of the patients included was 45.32 ± 16.88 years. Wide local excision was the most common surgical procedure employed for the resection of these tumors. Within the cohort, the mortality rate was noted to hover at 10.52%. Gastrointestinal stromal tumors were observed in 21% of the patients and were therefore the most common histological subtype. Of the patients included, 42.10% required blood transfusion during the perioperative time. Most of the tumors were noted to be intermediate grade, with high-grade tumors observed in 26.3% of the cases. Conclusion Soft tissue sarcomas remain a rare but potent cause of death in developing countries. The diversity of the tissues that they afflict renders their prompt detection a diagnostic challenge. A meticulous exploration of the various characteristics honed by soft tissue sarcomas, such as the particular histological subtype and the associated mortality rates, can better elucidate the prognosis and the eventual disease outcomes.

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“…Primary retroperitoneal tumors have many characteristics that are not conducive to clinical diagnosis, such as low incidence, deep location, strong adaptability, no obvious symptoms in early stage, large volume, and close relationship with surrounding organs. In particular, malignant tumors often involve multiple adjacent organs, which results in the low surgical resection rates . Therefore, the accurate localization and identification of primary retroperitoneal tumors will help to select treatment strategies and improve surgical resection rates.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

Feng

Zhang

Luo

2019

Clinical Laboratory Analysis

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Background To accurately identify primary retroperitoneal tumors by multi‐slice spiral CT (MSCT) for better treatment. Materials and Methods The common types of 380 cases of primary retroperitoneal tumor, lesion sites, and MSCT features were compared with pathological results. Fisher's or chi‐square test approaches have been applied in this study. Results Multi‐slice computerized tomography multi‐directional reconstruction has a high accuracy for primary retroperitoneal tumors (95.7%). Seventy‐three liposarcoma cases were located in peri‐renal space, accounting for 76.8% (13/95) of the tumors in this region. Meanwhile, 65 cases of neurogenic tumors were located in the paravertebral column, accounting for 90.3% (65/72) of the tumors in this region. MSCT examination could effectively distinguish benign from malignant of primary retroperitoneal tumor (sensitivity = 87.2%, specificity = 82.7%, accuracy rate = 84.5%). Malignant tumors showed more irregularity shape than benign tumor (χ2 = 20.468, P < .001). 82.7% (191/231) of the malignant tumors showed adhesion or even invasion of surrounding tissues and organs (χ2 = 23.262, P < .001). Fat density of the lipoma is uniform, and lesion is not enhanced. Liposarcoma can be seen in varying proportions of fat and soft tissue density. Conclusion The accuracy of MSCT scan for retroperitoneal tumors is high. Meanwhile, the coincidence rate of qualitative diagnosis before operation and/or before biopsy is also high.

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Surgical management of retroperitoneal sarcoma and opportunities for global collaboration

Cited by 28 publications

References 46 publications

Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10‐year experience of a single institute

Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10‐year experience of a single institute

Clinical and Pathological Characteristics of Soft Tissue Sarcomas: A Retrospective Study From a Developing Country

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

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