Surgical Management of Trigeminal Neuralgia in Children

Chicoine, Nicole H.; Yaacoub, Alan P.; Jea, Andrew; Raskin, Jeffrey S.

doi:10.1016/j.wneu.2018.10.074

Cited by 11 publications

(11 citation statements)

References 31 publications

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“…To date, no study has reported on its development before 20 years of age. To the best of our knowledge, only case series and case reports of single HDS have been published in pediatric and adolescent populations [ 8 – 16 ]. In the present report, we present an extremely rare case of combined HDS in an adolescent patient.…”

Section: Discussionmentioning

confidence: 99%

Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report

et al. 2021

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Background Hyperactive dysfunction syndrome (HDS) refers to a constellation of symptoms developing from cranial nerve overactivity caused by neurovascular compression at the root entry or exit zone near the brainstem. Although the combined features of HDS are seen in the elderly, there are no reports of such cases in adolescents, to date. Case presentation A 17-year-old male was diagnosed with right glossopharyngeal neuralgia and treated with microvascular decompression. He experienced new-onset right facial pain later and was diagnosed with right trigeminal neuralgia, which required prompt radiofrequency thermocoagulation of the right mandibular nerve. Follow-up in the third post-treatment year revealed the absence of symptom recurrence. Discussion We report the treatment of a rare case of adolescent-onset combined HDS presenting as trigeminal and glossopharyngeal neuralgia. This report highlights the possibility of combined hyperactive dysfunction syndrome in younger age groups. It is crucial to establish a diagnosis early on for prompt management.

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Section: Discussionmentioning

confidence: 99%

Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report

et al. 2021

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“…Chicoine et al 6 described two girls diagnosed with classical trigeminal neuralgia where treatment with several drugs failed, including indomed, naproxen, carbamazepine and oxcarbazepine, and gabapentin. Microsurgical nerve decompression resulted in symptom resolution.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported treatment with oral medication combined with nerve block or followed by surgery in cases of failure. However, the authors did not provide a description of the clinical symptoms or the response to pharmacologic treatment 6,7 …”

Section: Introductionmentioning

confidence: 99%

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Trigeminal neuralgia in children and adolescents: Experience of a tertiary pediatric headache clinic

2020

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Objectives To describe the characteristics and treatment of trigeminal neuralgia in children attending a dedicated pediatric headache clinic. Background Data on trigeminal neuralgia as a cause of headache are largely derived from adult studies. Little is known about the etiology, symptoms, treatment, and outcome of the disorder in children and adolescents. Methods A case series study was undertaken. The database of a headache clinic within a tertiary, university‐affiliated, pediatric medical center was searched for all patients aged 3–18 years presenting with clinical and epidemiological features of trigeminal neuralgia or trigeminal neuropathy from January 2015 to December 2019. The diagnosis was revised for the present study according to the criteria of the International Classification of Headache Disorders, third edition. Data on demographic parameters, clinical symptoms, treatment, and outcome were collected from the medical files. Results Of the 1040 patients who presented to our clinic during the study period, five (0.5%) were diagnosed with trigeminal neuralgia. Mean patient age was 15.1 ± 3.0 years (range 9.5–17.5; 95% CI 10.8–18.9). All had idiopathic type: purely paroxysmal in one and with concomitant continuous pain in four. Findings on herpes serology in all five and magnetic resonance imaging were normal in four patients. In the fifth, a vascular ring was noted from the superior cerebellar artery around the right trigeminal nerve without radiologic evidence of vascular nerve compression. All patients were initially treated with carbamazepine: one reported partial relief, two did not respond, and two had severe adverse effects. Three patients were switched to gabapentin but only one responded well. Three patients were treated with nerve block. Conclusion Trigeminal neuralgia accounted for only a small proportion of patients seeking treatment for headache in pediatric headache clinic over a 5‐year period. Unlike findings in adults, vascular compression was not the underlying mechanism in any of our patients. The response to pharmacologic treatment was poor. Nerve block may serve as an alternative when pharmacologic treatment fails.

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“…Considering complex management [9], medications with serious side effects [10] and symptoms that are frequently mistaken for dental or jaw pain [8,11], TN patients may face psychological issues leading to mild to severe functional limitation of daily life activities [12], which -based on studies in Europe [2]-could lead to suicide. The incident is more prevalent among women older than 40 years old [13]; however, studies reported cases before age 20 in 1% -1.5% of patients [14].…”

Section: Introductionmentioning

confidence: 97%

An Exploratory Study of Social Media Analysis for Rare Diseases Using Machine Learning Algorithms: A Case Study of Trigeminal Neuralgia

Mombini¹,

Li²,

Zhang³

et al. 2020

Proceedings of the Annual Hawaii International Conference on System Sciences

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Rare diseases, affecting approximately 30 million Americans, are often poorly understood by clinicians due to lack of familiarity with the disease and proper research. Patients with rare diseases are often unfavorably treated, especially those with extremely painful chronic orofacial rare disorders. In the absence of structured knowledge, such patients often choose social media to seek help from peers within patient-oriented social media communities thereby generating tremendous amounts of unstructured data daily. We investigate whether we can organize this unstructured data using machine learning to help members of rare communities find relevant information more efficiently in real-time. We chose Trigeminal Neuralgia (TN), an extremely painful rare disorder, as our case study and collected 20,000 social media TN posts. We categorized TN posts into Twitter (very short), and Facebook (short, medium, long) datasets based on message length and performed three clustering experiments. Results revealed GSDMM outperformed both K-means and Spherical K-means in clustering Facebook especially for short messages in terms of speed. For long messages, MDS reduction outperformed the PCA when both were used with K-means and Spherical K-means. Our study demonstrated the need for further topic modeling to utilize among high level clusters based on semantic analysis of posts within each cluster.

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Surgical Management of Trigeminal Neuralgia in Children

Cited by 11 publications

References 31 publications

Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report

Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report

Trigeminal neuralgia in children and adolescents: Experience of a tertiary pediatric headache clinic

An Exploratory Study of Social Media Analysis for Rare Diseases Using Machine Learning Algorithms: A Case Study of Trigeminal Neuralgia

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