Trigeminal neuralgia in children and adolescents: Experience of a tertiary pediatric headache clinic

Abstract

Objectives To describe the characteristics and treatment of trigeminal neuralgia in children attending a dedicated pediatric headache clinic. Background Data on trigeminal neuralgia as a cause of headache are largely derived from adult studies. Little is known about the etiology, symptoms, treatment, and outcome of the disorder in children and adolescents. Methods A case series study was undertaken. The database of a headache clinic within a tertiary, university‐affiliated, pediatric medical center was searched for all patients aged 3–18 years presenting with clinical and epidemiological features of trigeminal neuralgia or trigeminal neuropathy from January 2015 to December 2019. The diagnosis was revised for the present study according to the criteria of the International Classification of Headache Disorders, third edition. Data on demographic parameters, clinical symptoms, treatment, and outcome were collected from the medical files. Results Of the 1040 patients who presented to our clinic during the study period, five (0.5%) were diagnosed with trigeminal neuralgia. Mean patient age was 15.1 ± 3.0 years (range 9.5–17.5; 95% CI 10.8–18.9). All had idiopathic type: purely paroxysmal in one and with concomitant continuous pain in four. Findings on herpes serology in all five and magnetic resonance imaging were normal in four patients. In the fifth, a vascular ring was noted from the superior cerebellar artery around the right trigeminal nerve without radiologic evidence of vascular nerve compression. All patients were initially treated with carbamazepine: one reported partial relief, two did not respond, and two had severe adverse effects. Three patients were switched to gabapentin but only one responded well. Three patients were treated with nerve block. Conclusion Trigeminal neuralgia accounted for only a small proportion of patients seeking treatment for headache in pediatric headache clinic over a 5‐year period. Unlike findings in adults, vascular compression was not the underlying mechanism in any of our patients. The response to pharmacologic treatment was poor. Nerve block may serve as an alternative when pharmacologic treatment fails.

Trigeminal neuralgia: a practical guide

“…1 7 Furthermore, a recent paediatric headache clinic of 1040 identified five children in the age range 9.5-16.5 years with TN. 8…”

Comparison of carbamazepine alone and in combination with baclofen in trigeminal neuralgia

“…Compared to other neuropathic pain syndromes, trigeminal neuralgia responds more favorably to medication treatment. The effectiveness of carbamazepine has previously been established in numerous studies, and it is frequently used as a first-line therapy for TN (18). This research was done to find out whether carbamazepine works well when combined with other medication as a different therapy option.…”

Virtual issue: Cranial neuralgias

“…Brameli et al review a series of five children with trigeminal neuralgia. Each of these pediatric patients had involvement of the V1 branch, and two described pain and triggers only within V1 7 8 …”