Surgical outcomes in patients with intraoperative Electrocorticography (EcoG) guided epilepsy surgery-experiences of a tertiary care centre in India

Ravat, Sangeeta; Iyer, Vivek; Panchal, Keyurkumar; Muzumdar, Dattatraya; Kulkarni, Abhijit

doi:10.1016/j.ijsu.2016.02.047

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…The primary reason for poor surgical outcomes in patients with FCD is the inaccurate localization of the epileptogenic margins. These results further support that EcoG-guided resection is likely to have a better outcome in terms of achieving seizure freedom post-operatively [ 22 , 101 ].…”

Section: Discussionsupporting

confidence: 61%

Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

et al. 2021

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Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hence, identifying novel epileptogenic markers to aid in the localization of EZ in patients with FCD is very much needed. High-throughput gene expression studies of FCD samples have the potential to uncover molecular changes underlying the epileptogenic process and identify novel markers for delineating the EZ. For this purpose, we, for the first time performed RNA sequencing of surgically resected paired tissue samples obtained from electrocorticographically graded high (MAX) and low spiking (MIN) regions of FCD type II patients and autopsy controls. We identified significant changes in the MAX samples of the FCD type II patients when compared to non-epileptic controls, but not in the case of MIN samples. We found significant enrichment for myelination, oligodendrocyte development and differentiation, neuronal and axon ensheathment, phospholipid metabolism, cell adhesion and cytoskeleton, semaphorins, and ion channels in the MAX region. Through the integration of both MAX vs non-epileptic control and MAX vs MIN RNA sequencing (RNA Seq) data, PLP1, PLLP, UGT8, KLK6, SOX10, MOG, MAG, MOBP, ANLN, ERMN, SPP1, CLDN11, TNC, GPR37, SLC12A2, ABCA2, ABCA8, ASPA, P2RX7, CERS2, MAP4K4, TF, CTGF, Semaphorins, Opalin, FGFs, CALB2, and TNC were identified as potential key regulators of multiple pathways related to FCD type II pathology. We have identified novel epileptogenic marker elements that may contribute to epileptogenicity in patients with FCD and could be possible markers for the localization of EZ.

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Section: Discussionsupporting

confidence: 61%

Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

et al. 2021

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“…Both can be achieved effectively after implementing intraoperative ECoG. In another study, it was observed that epileptic patients that were undergoing intraoperative ECoG-guided epileptic surgery demonstrated an improved post-surgical outcome, compared to patients getting normal or non-guided epileptic surgery [ 16 ]. Extraoperative ECoG can also be very useful in non-surgical epileptic treatments to identify the epileptic foci and to track the disease progression.…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements

Bandopadhyay

Singh

Ghoneim

et al. 2021

Biology

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Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, resulting from abnormally synchronized episodic neuronal discharges. Around 70 million people worldwide are suffering from epilepsy. The available antiepileptic medications are capable of controlling seizures in around 60–70% of patients, while the rest remain refractory. Poor seizure control is often associated with neuro-psychiatric comorbidities, mainly including memory impairment, depression, psychosis, neurodegeneration, motor impairment, neuroendocrine dysfunction, etc., resulting in poor prognosis. Effective treatment relies on early and correct detection of epileptic foci. Although there are currently a few well-established diagnostic techniques for epilepsy, they lack accuracy and cannot be applied to patients who are unsupportive or harbor metallic implants. Since a single test result from one of these techniques does not provide complete information about the epileptic foci, it is necessary to develop novel diagnostic tools. Herein, we provide a comprehensive overview of the current diagnostic tools of epilepsy, including electroencephalography (EEG) as well as structural and functional neuroimaging. We further discuss recent trends and advances in the diagnosis of epilepsy that will enable more effective diagnosis and clinical management of patients.

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“…Typically the electrodes are made of platinum [25][26][27] and are placed on the surface of the cortex [28]. Ravat et al [29] studied the potential use of ECoG for the diagnosis and therapy of epilepsy [30] and concluded that the success of an Epileptic surgery depends on the accurate localization and removal of the epileptogenic tissue [29]. Rosenow defined the epileptogenic zone as the area of the cortex indispensable for the generation of clinical seizures [31].…”

Section: Uses Of Ecog and Epilepsymentioning

confidence: 99%

Distributed mixed signal demultiplexer for electrocorticography electrodes

Marcoleta

Nogueira

Doll

2020

Biomed. Phys. Eng. Express

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This work presents a novel architecture, exemplified for electrophysiological applications like ECoG that can be used to detect Epilepsy. The new ECoG is based on a mixed analog-digital architecture (Pulse Amplitude Modulation PAM), that allows the use of thousands of electrodes for recording. Whilst the increased number of electrodes helps to refine the spatial resolution of the medical application, the transmission of the signals from the electrodes to an external analysing device appears to be a bottleneck. To overcoming this, our work presents a hardware architecture and corresponding protocol for a mixed architecture that improves the information density between channels and their signal-to-noise ratio. This is shown by the correlation between the input and the transmitted signals in comparison to a classical digital transmission (Pulse Code Modulation PCM) system. We show in this work that it is possible to transmit the signals of 10 channels with a analog-digital architecture with the same quality of a full digital architecture.

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Surgical outcomes in patients with intraoperative Electrocorticography (EcoG) guided epilepsy surgery-experiences of a tertiary care centre in India

Cited by 12 publications

References 38 publications

Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements

Distributed mixed signal demultiplexer for electrocorticography electrodes

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