Surgical Outcomes of Cerebellar Tumors in Children

Akay, Kamil Melih; İzci, Yusuf; Baysefer, Alper; Atabey, Cem; Kısmet, Erol; Tımurkaynak, Erdener

doi:10.1159/000082295

Cited by 25 publications

(16 citation statements)

References 34 publications

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“…The causes are: postoperative edema of cerebellum, obstruction to CSF re-absorption due to subarachnoid hemorrhage, adhesion of the opening to the fourth ventricle and its surroundings, and etc. [7,8] Postoperative hydrocephalus is the most severe complication of the surgery for pediatric tumor of posterior cranial fossa and even endangers life if not properly treated. Therefore, soon after the surgery, ventriculoperitoneal shunt or ventriculostomy under neuroendoscope should be performed if circumstances allow.…”

Section: Discussionmentioning

confidence: 99%

“…For malignant pediatric tumor of posterior cranial fossa, treatment relies on complementary radiotherapy and/or chemotherapy on the basis of performing surgery [8] . Debate remains on the question of how to select complementary therapies which are suitable for the certain pathological types of the tumor [8][9][10] . We believed that therapy should be individualized, according to the age of the patients, the characteristics of tumors, surgical conditions, and tumor's sensitivity to radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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The microscopic surgical treatment for tumor of posterior cranial fossa in children

Chen

Wei

Yin

et al. 2009

Clin. Oncol. Cancer Res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The microscopic surgical treatment for tumor of posterior cranial fossa in children

Chen

Wei

Yin

et al. 2009

Clin. Oncol. Cancer Res.

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“…Usually, these data pertain to single tumor entities, such as medulloblastomas, brain stem tumors, or ependymomas. However, outcome data on mixed tumor case series have not been reported frequently, whereas for most centers treating children with brain tumors, these data may be more pertinent to compare to than the outcome data on single tumor entities, which are often derived from renowned, large pediatric neurosurgical centers, which are not readily accessible for most patients around the world [1, 3, 19, 22]. …”

Section: Objectivementioning

confidence: 99%

Surgical morbidity and mortality of pediatric brain tumors: a single center audit

et al. 2010

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ObjectivesThe primary aim of this study is to perform an internal quality control of pediatric brain tumor surgery in the neurosurgical department of the VU University Medical Center Amsterdam (The Netherlands). Secondly, this study aims to contribute to the accumulating data concerning outcome in pediatric neurosurgery, in order to establish institutional practice benchmarks.MethodsWe report the surgical mortality and morbidity of 121 patients (0–18 years) surgically treated for a brain tumor from January 1999 to August 2007. Patients, in whom only a brain tumor biopsy was performed, were excluded.ResultsMean age at first surgery was 8.2 years. Of the 121 patients, 14 had a second surgery, and two underwent a third surgery (for a total of 137 operations). Of all 121 primary surgeries, 66% were total resections, 26% subtotal resections, and 8% partial resections. The overall surgical morbidity rate in this study was 69% after first surgery, 50% after second surgery, and one out of two after third surgery.ConclusionThese overall morbidity rates are comparable to other published mixed case series. The surgical mortality rate was 0.8%; this is comparable to the lowest rates reported for high-volume neurosurgical centers. We encourage other neurosurgical centers to collect, analyze, and publish their data. These data can then serve as a basis for comparison with other pediatric neurosurgical centers and will eventually lead to an improvement of pediatric neurosurgical practice and patient care.

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“…For example, the evaluation of extent of resection by neurosurgeons is notoriously inaccurate though other retrospective series have concluded that a gross total resection is associated with favorable survivals. 34,35 In addition, the small size of our study also limits our comments regarding treatment.…”

Section: Discussionmentioning

confidence: 89%

Population-based Study of Medulloblastoma: Outcomes in Alberta from 1975 to 1996

Roldán

Brasher

Vecil

et al. 2008

Can. j. neurol. sci.

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Medulloblastoma is the most common malignant brain tumor of the central nervous system (CNS) in children, accounting for approximately 20% of all pediatric brain tumors.1,2 It is comparatively rare in adults, with a reported incidence rate of 0.05/100,000 per year, accounting for 1% of all primary tumors of the CNS. 3,4 There are few reported studies concerning adults and when reported, adults constitute a small part of the study group. [5][6][7] Previous studies of outcomes in medulloblastoma patients are based on case series or institutional experiences which were limited by referral and selection biases. 8,9 To our knowledge, there are no population-based studies of children and ABSTRACT: Background: The purpose of this study was to determine incidence, survival rate, and prognostic factors as well as the frequency of Collins' Law Violators (CLVs) in an unselected population of medulloblastoma patients. Collins' Law dictates that 'cure' of a child with a tumor occurs after a period that includes the child's age at diagnosis plus 9 months. Methods: Using the Alberta Cancer Registry a population-based review identified 49 patients with medulloblastoma (19 adults, 30 children) diagnosed from 1975-96. Pathology was reviewed in all cases. All patients had surgical resection, followed by radiotherapy in 47 patients and chemotherapy in 17. Results: The overall 5-year survival was 50%. There was a trend for the extent of resection to be associated with a longer survival (Long rank test, p< 0.06) but this was not significant. Tumor recurrence occurred a median of 22.4 months (range, 6.4-192.3) after diagnosis and median survival after recurrence was 9.3 months (range, 0.4-64.9). The survival curve did not appear to plateau but was affected by tumor-related deaths in 3 (21.4%) of the 21 long-term survivors diagnosed in childhood. These three patients had recurrences a mean of 11.7 years after diagnosis and are designated as CLVs. Conclusions: The survival rate in an unselected population of patients with medulloblastoma is poor. Aggressive resection of the tumors prolongs survival. The Collins' Law Violators were relatively common and we suggest this concept be abandoned in medulloblastoma. RÉSUMÉ: Étude de population sur le médulloblastome en Alberta de 1975 à 1996.Contexte : Le but de cette étude était d'évaluer l'incidence, le taux de survie et les facteurs influençant le pronostic ainsi que la fréquence des contrevenants à la loi de Collins dans une population non sélectionnée de patients atteints de médulloblastome. Selon la loi de Collins, un enfant atteint d'une tumeur est guéri après un temps défini par l'âge de l'enfant au moment du diagnostic plus 9 mois. Méthodes : Nous avons identifié 49 patients atteints de médulloblastome (19 adultes et 30 enfants) dans le Alberta Cancer Registry, entre 1975 et 1996. L'anatomopathologie a été révisée dans tous les cas. Tous les patients avaient subi une résection chirurgicale suivie de radiothérapie chez 47 patients et de chimiothérapie chez 17 patients. Résultats : La su...

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Surgical Outcomes of Cerebellar Tumors in Children

Cited by 25 publications

References 34 publications

The microscopic surgical treatment for tumor of posterior cranial fossa in children

The microscopic surgical treatment for tumor of posterior cranial fossa in children

Surgical morbidity and mortality of pediatric brain tumors: a single center audit

Population-based Study of Medulloblastoma: Outcomes in Alberta from 1975 to 1996

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