Surgical problems in the management of giant fibroadenoma of the breast

Davis, Carl; Patel, Vishal

doi:10.1016/0002-9378(85)90549-6

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…There appears to be a variable incidence of giant fibroadenomas in different racial groups. Those occurring in adolescence are believed to be more common in Black Africans and Asian people than in Caucasians 6,10–12 . In a mixed population of Asian people, giant fibroadenomas of adolescence occurred more frequently in Chinese women than in Malaysians or Indians 13 .…”

Section: Discussionmentioning

confidence: 99%

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Giant fibroadenoma of the breast in an Arab population

Hanna

Ashebu

2002

Australasian Radiology

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In a retrospective study of giant breast masses over a period of 20 years (1980-2000), we encountered 18 patients with fibroadenomas. Most of them were adolescents and young adults. The bimodal age incidence seen in Caucasians was not observed. The masses ranged from 6 to 15 cm in size and in the youngest patient, they were bilateral. All 18 patients were examined by mammography and 10 of them by ultrasonography (US) as well. The right breast was involved in 12 patients and the left in six. The diagnosis was confirmed pathologically in all patients, by excision biopsy in 17 patients and by fine needle aspiration cytology and excision biopsy in one patient. The radiological findings were the same as those previously described. All patients were treated by simple enuculation. There was only one recurrence over a follow-up period from 2 months to 3 years.

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Section: Discussionmentioning

confidence: 99%

“…Mastectomy might occasionally be necessary, for example, when there is extensive skin ulceration 10 . However, as emphasized by Davis and Patel, surgical treatment must be individualized 12 …”

Section: Discussionmentioning

confidence: 99%

Giant fibroadenoma of the breast in an Arab population

Hanna

Ashebu

2002

Australasian Radiology

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“…Nonetheless, they are often unsightly and disconcerting to the patient. Treatment is most often excision, although their bulk can make removal difficult, often necessitating general anesthesia (3,15). There is no need for generous surgical margins.…”

Section: Commentmentioning

confidence: 99%

A 19 Year Old with Complete Androgen Insensitivity Syndrome and Juvenile Fibroadenoma of the Breast

Davis

Wallace

2001

Breast Journal

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We report a case of a 19-year-old female with complete androgen insensitivity syndrome (CAIS) who was diagnosed with a juvenile fibdroadenoma of the breast. The patient presented at age 18 with primary amenorrhea. She had been raised as a female and went through thelarche at age 13 and adrenarche at age 14. She had two sisters and three maternal aunts with androgen insensitivity syndrome. Physical exam revealed that the patient had no cervix, and a pelvic sonogram confirmed that the uterus was absent. Genetic analysis revealed a 46 XY karyotype. Bilateral intra-abdominal testes were noted on ultrasound and subsequently removed. She was placed on synthetic estrogen replacement therapy. Roughly 1 year following orchiectomy, the patient noticed an enlarging mass in her right breast. Physical exam revealed a roughly 5 cm mobile mass in the upper portion of the nipple-areolar complex. Ultrasound showed a solid mass consistent with a fibroadenoma. Because of the size of the lesion and the patient's hormonal make-up, a fine needle aspirate was obtained. Cytopathology showed large cohesive sheets of ductal epithelial cells, scattered histiocytes, numerous bare nuclei, fragments of fibrous tissue and metachromatic stroma. Some of the stroma was noted to be cellular. The tumor was subsequently excised. Microscopically, the lesion had epithelial and stromal hyperplasia consistent with a fibroadenoma. Phyllodes-like qualities of large size, increased stromal cellularity, and intracanalicular growth ("leaf-like projections") were noted; however, the pathologist found that the florid epithelial hyperplasia and the patient's young age were more compatible with a juvenile fibroadenoma. We describe what we believe to be the first report of a patient with CAIS and a fibroadenoma of the breast. The hormonal imbalance typically found in these patients, combined with the fact that most individuals with CAIS receive exogenous estrogen therapy, suggests that there may be a relatively high incidence of fibroadenoma in these patients.

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“…There is no recognized standardized surgical treatment for multiple giant fibroadenomas and cystosarcoma phyl loides [7]. Though local excision of the tumor is the pre ferred treatment in most cases, mastectomies have also been carried out.…”

Section: Multiple Giant Fibroadenomasmentioning

confidence: 99%

Multiple Giant Fibroadenomas: Clinical Presentation and Radiologic Findings

Schneider¹,

Laubenberger²,

Kommoss

et al. 1997

Gynecol Obstet Invest

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We describe the case of a 25-year-old Caucasian woman suffering from unilateral enlargement of the breast. Morphologic evaluation of various imaging modalities including mammography, ultrasound, and magnetic resonance imaging suggested a benign tumor embedded in stromal tissue. The time course of the Gd-DTPA uptake in dynamic magnetic resonance imaging, however, was also compatible with a malignant lesion. Postoperative pathological examination revealed multiple giant fibroadenomas, a rare disease, usually encountered in black female adolescents. Radiologic presentation, differential diagnosis, and morphologic findings are discussed, and a review of the literature is contained herein.

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Surgical problems in the management of giant fibroadenoma of the breast

Cited by 10 publications

References 10 publications

Giant fibroadenoma of the breast in an Arab population

Giant fibroadenoma of the breast in an Arab population

A 19 Year Old with Complete Androgen Insensitivity Syndrome and Juvenile Fibroadenoma of the Breast

Multiple Giant Fibroadenomas: Clinical Presentation and Radiologic Findings

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