Surgical reconstruction in patients with cancer of the head and neck

Vural, Emre

doi:10.1007/s11912-004-0025-2

Cited by 17 publications

(11 citation statements)

References 34 publications

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“…cancers. [1][2][3] Improved medical managements of cancer have prolonged survival rate, with the result that cancer survivors wish to have the morphology and function of their soft tissue defects restored. 1,4,5 Injuries take place during war, leading to soft tissue trauma in addition to skeletal injuries.…”

mentioning

confidence: 99%

Stem Cell-Based Soft Tissue Grafts for Plastic and Reconstructive Surgeries

Stosich¹,

Mao²

2005

Seminars in Plastic Surgery

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Adipose tissue is often a key structure to restore in reconstructive and augmentative surgeries. Current materials for soft tissue reconstruction or augmentation suffer from shortcomings such as suboptimal volume retention, donor site morbidity, and poor biocompatibility. A series of experiments are presented here to describe our stem cell-based approach to engineering human adipose tissue with predefined shape and dimensions. These findings indicate the real possibility that biologically viable adipose tissue can be engineered by taking a teaspoon full of tissue fluid containing the patient's adult stem cells, expanding them, differentiating them into adipogenic cells, and encapsulating them into appropriate biocompatible polymer materials. The end result is anticipated to be minimal donor site trauma related to needle size, immune compatibility because the patient's own stem cells are used, and long-term volume maintenance because stem cells are capable of replenishing adipogenic cells to retain the predefined shape and dimensions of the engineered soft tissue. Upcoming challenges include long-term volume maintenance, tissue maturation, angiogenesis, scaling up, and host tissue integration. Conceptually, stem cell-derived soft tissue grafts are realizable in plastic and reconstructive surgical procedures.

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mentioning

confidence: 99%

Stem Cell-Based Soft Tissue Grafts for Plastic and Reconstructive Surgeries

Stosich¹,

Mao²

2005

Seminars in Plastic Surgery

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“…Although grafts in the form of skin, dermis, cartilage, bone, fascia and fat are indispensible tools of reconstructive surgery; their reliability may be questionable due to their avascular nature, especially in the presence of less than optimal recipient bed conditions such as diabetes, burns or prior irradiation 10 . Increasing the reliability of grafts regardless of their nature would provide invaluable benefit to the patients undergoing reconstructive surgery involving utilization of graft materials.…”

Section: Discussionmentioning

confidence: 99%

Skin Graft Take Rates, Granulation, and Epithelialization

Vural

Berbée²,

Acott³

et al. 2010

Arch Otolaryngol Head Neck Surg

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Objective Production of the alpha subunit of Hypoxia Inducible Factor (HIF-1α) is increased in healing wounds, which stimulates expression of Vascular Endothelial Growth Factor (VEGF) to promote angiogenesis. Therefore, take rate of skin grafts may be closely associated with the presence or absence of HIF-1α production in the recipient bed. We compared the take rates of skin grafts between myeloid selective HIF-1α knock-out (KO) and wild-type (WT) mice. Design Percentage of healthy graft areas obtained by planimetry and scores for epithelialization and granulation tissue formation obtained by histopathological analysis were compared in twelve KO and twelve WT mice following skin grafting. Results Graft take rate was significantly impaired in the KO group, while epithelialization or granulation tissue formation scores did not reveal any significant differences. Conclusion HIF-1α in myeloid cells may be an important molecule for re-vascularization of avascular tissues such as skin grafts, probably due to its stimulating effect on angiogenesis.

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“…The best results, in terms of survival, are obtained through a combination of chemotherapy, radiation and surgical treatment 3,4) . However, surgery on the MFA is often accompanied by complex and serious defects, which can result in disturbance of the functions of chewing, swallowing, respiration, and speech 5) . Furthermore, cosmetic changes to the face may have a negative influence on the patients' mental state, and their return to society is another major problem of MFA and neck tumors.…”

Section: Introductionmentioning

confidence: 99%

Benefit of rehabilitation for patients with postoperative defects due to maxillofacial tumors

Asatullaevich

Maeda

Amrulloevich

et al. 2019

Ann. Cancer Res. Therap.

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Background: This study aimed to demonstrate the usefulness of our rehabilitation program after extensive surgeries in patients with maxillofacial area (MFA) and neck tumors. Methods: Data from patients who underwent surgery in the clinics of the Republican Oncological Research Center and the Tashkent Institute of Postgraduate Medical Education for MFA and neck tumors were retrospectively analyzed. The patients were enrolled to our rehabilitation program, which consisted of a three-staged technique involving a complex prosthesis, and several physical therapies for damaged functions, such as chewing, swallowing, and breathing. Results: A total of 107 oncological patients with postsurgical defects were fitted with various types of prosthesis. The introduction of our rehabilitation program was performed at an interval between initial surgery and prosthesis formation of 10-15 days, and between initial surgery and preparation of the final prosthesis of 26-30 days. A restoration of the Karnofsky performance status to 80%-85% was observed. Conclusion: The present study demonstrates that our rehabilitation program is useful for shortening the postoperative convalescent period and improving the quality of life of patients with defects of the MFA and neck.

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Surgical reconstruction in patients with cancer of the head and neck

Cited by 17 publications

References 34 publications

Stem Cell-Based Soft Tissue Grafts for Plastic and Reconstructive Surgeries

Stem Cell-Based Soft Tissue Grafts for Plastic and Reconstructive Surgeries

Skin Graft Take Rates, Granulation, and Epithelialization

Benefit of rehabilitation for patients with postoperative defects due to maxillofacial tumors

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