Surgical Results of Synchronous Multiple Primary Lung Cancers: Similar to the Stage-Matched Solitary Primary Lung Cancers?

Yu, Yu Chao; Hsu, Po Kuei; Yeh, Yi Chen; Huang, Chien Sheng; Hsieh, Chih Cheng; Chou, Teh Ying; Hsu, Han Shui; Wu, Yu Chung; Huang, Bin; Hsu, Wen Hu

doi:10.1016/j.athoracsur.2013.04.142

Cited by 88 publications

(94 citation statements)

References 21 publications

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“…For patients with an enlarged solitary pulmonary nodule that developed after the first operation, CT‐guided or surgical biopsy was performed for tissue diagnosis if indicated, and comprehensive histological subtyping compared with the original tumor to distinguish metachronous from metastatic. Patients with synchronous unresected GGO nodules and metachronous tumors were excluded to distinguish ipsilateral and contralateral recurrence at the beginning of the study . The disease‐free survival (DFS) was defined as the interval between the date of surgical resection to the date of first recurrence or the last date of follow‐up.…”

Section: Methodsmentioning

confidence: 99%

Surgeons' preference sublobar resection for stage I NSCLC less than 3 cm

et al. 2020

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Background This study aimed to compare survival between standard lobectomy and surgeons' preference sublobar resection among patients with stage I non‐small cell lung cancer (NSCLC). Methods Medical records of patients undergoing pulmonary resection between 2006 and 2016 were reviewed retrospectively. Differences in disease‐free survival (DFS) and DFS‐associated factors between patients receiving lobectomy and surgeons' preference sublobar resection were analyzed after 1‐1 propensity score‐matching (n = 119 per group). Results In total, 1064 pathological stage I NSCLC patients were identified, including 816 (76.7%) who underwent lobectomy, 111 (10.4%) who underwent sublobar resection as a compromised procedure (medically unfit), and 137 (12.9%) who underwent surgeons' preference sublobar resection. Rates of five‐year DFS for patients undergoing lobectomy, medically unfit, and surgeons' preference sublobar resection were 88.7%, 71.0%, and 93.4%, respectively (P < 0.001). Multivariable Cox regression analysis demonstrated that radiological solid‐appearance (adjusted hazard [aHR] = 2.908, P = 0.003), PL2 invasion (aHR = 1.970, P = 0.024), and angiolymphatic invasion (aHR = 2.202, P = 0.005) were significantly associated with lower DFS after adjusting for surgeons' preference sublobar resection (aH = 1.031, P = 0.939). Subgroup analysis of all 403 solid‐dominant patients demonstrated equivalent five‐year DFS between surgeons' preference sublobar resection and lobectomy (87.7% and 84.1%, respectively, P = 0.721). Propensity‐matched analysis showed no differences in five‐year DFS in stage I NSCLC patients undergoing lobectomy or surgeons' preference sublobar resection (90.5% vs. 93.4% P = 0.510), and DFS for surgeons' preference sublobar resection remained an insignificant factor (aHR = 0.894, P = 0.834). Conclusions Carefully selected patients who have undergone surgeons' preference sublobar resection have comparable outcomes to those receiving lobectomy for stage I NSCLC <3 cm. Key points Significant findings of the study Intended sublobar resection has a good outcome. What this study adds Sublobar resection is applicable for stage I NSCLC <3 cm.

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Section: Methodsmentioning

confidence: 99%

Surgeons' preference sublobar resection for stage I NSCLC less than 3 cm

et al. 2020

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“…While another study [25] focused on the OS between stage T3 (containing PM) and MPLC. Arai [23] and Yu [25] only described synchronous MPLC. Ono [24] combined both synchronous and metachronous MPLC.…”

Section: Intrapulmonary Metastasis (Pm) Vs Mplcmentioning

confidence: 99%

Prognosis of synchronous and metachronous multiple primary lung cancers: Systematic review and meta-analysis

Jiang

Shi

et al. 2015

Lung Cancer

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“…Whereas the overall survival rate (OS) of patients diagnosed with SMPLC had been reported to be significantly lower than in patients with single primary lung cancers (SPLC) [24], Yu et al. reported that there was no significant difference in OS between SPMLC and SPLC [25]. While tumor size is thought to be an important predictor of OS in SMPLC [26], the presence of lymphovascular invasion and the morphologic type of SMPLC do not significantly affect OS according to Yu et al.…”

Section: Discussionmentioning

confidence: 96%

Synchronous mucinous and non-mucinous lung adenocarcinomas with different epidermal growth mutational status

Linhas

Tente

Dias

et al. 2017

Respiratory Medicine Case Reports

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In recent years, the spread of more-sensitive diagnostic methods has resulted in an increase of synchronous multiple primary lung cancer diagnosis. Nevertheless, its occurrence is still rare. Distinction between synchronous lesions from second independent primary tumors is a problem when dealing with multiple lung tumors, particularly if the histological type is the same. We present a case report of a 78-year-old female patient referred to our institution due to pneumonia. A subsequent thoracic computed tomography (CT) was performed showing two suspicious lesions, one in the right upper lobe and the other in the right inferior lobe. The CT-guided transthoracic needle biopsy of both pulmonary lesions revealed two adenocarcinomas, but with a rare combination of distinct morphologic variants, as well as different immunophenotypes and epidermal growth factor receptor (EGFR) gene status. The patient refused surgery and was submitted to stereotactic body radiation therapy (SBRT). She maintained tight follow-up and until now, she has not shown any signs of relapse or metastasis. A multidisciplinary approach with clinical, morphologic and molecular evaluation in multiple lung cancer is important to diagnosis and treatment guidance.

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Surgical Results of Synchronous Multiple Primary Lung Cancers: Similar to the Stage-Matched Solitary Primary Lung Cancers?

Cited by 88 publications

References 21 publications

Surgeons' preference sublobar resection for stage I NSCLC less than 3 cm

Surgeons' preference sublobar resection for stage I NSCLC less than 3 cm

Prognosis of synchronous and metachronous multiple primary lung cancers: Systematic review and meta-analysis

Synchronous mucinous and non-mucinous lung adenocarcinomas with different epidermal growth mutational status

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