Surgical Therapy for Anorectal Melanoma

Bullard, Kelli M.; Tuttle, Todd M.; Rothenberger, David A.; Madoff, Robert D.; Baxter, Nancy N.; Finne, Charles O.; Spencer, Michael P.

doi:10.1016/s1072-7515(02)01538-7

Cited by 127 publications

(133 citation statements)

References 44 publications

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“…In one series, however, local excision resulted in better local control than APR, though this may be partly due to the use of adjuvant RT in some patients who underwent WLE. [11] The apparent improvement in survival of patients treated with WLE and adjuvant RT in our series may be due to the fact that a higher percentage of patients in this group had early stage disease (confined to the mucosa) and smaller tumors as compared to the patients treated by APR.…”

Section: Discussionmentioning

confidence: 66%

“…[3] The five-year overall survival in patients with anorectal melanoma ranges from 4 to 31%, while the median survival varies from 16 to 28 months. [4][5][6][7][8][9][10][11] There are no definite recommendations for the management of these lesions. Treatment strategies have varied from the radical abdominoperineal resection (APR) to the conservative wide local excision (WLE).…”

Section: Introductionmentioning

confidence: 99%

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Optimizing local control in anorectal melanoma

Mahajan

Kannan

2008

Indian J Cancer

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13of anorectal melanoma were evaluated in our institution. These patients were identified from the computer data base in our tumor registry using the ICD-O (third edition) site codes for anus and rectum (C21.0, C44.5 and C20.9) and the morphology code for melanoma (M-8720/3). The case records of these patients were retrospectively reviewed in detail to obtain information regarding clinical features (symptoms, duration, investigations and stage), pathological features (size, depth of invasion and immunohistochemical studies), treatment and follow-up details. Depth of the lesion was assessed either by histopathological examination of the surgical specimen or by clinical examination in patients who did not undergo surgery.Immunohistochemistry (IHC), performed by the streptavidin-biotin-peroxidase method was used to further categorize anorectal tumors labelled on routine Optimizing local control in anorectal melanomaRamakrishnan AS, Mahajan V, Kannan R Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai -600 036, Tamil Nadu, IndiaCorrespondence to: Dr. Ramakrishnan AS, E-mail: ram_a_s@yahoo.com Abstract BACKGROUND: Wide local excision (WLE) of anorectal melanoma is associated with a high incidence of local recurrence.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Optimizing local control in anorectal melanoma

Mahajan

Kannan

2008

Indian J Cancer

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“…SLN dissection has been used in anorectal melanoma. 17 A few case reports exist regarding the technical feasibility of SLN with anorectal melanoma, 18 but the efficacy remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Primary anal malignant melanoma: a case report

et al. 2015

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“…However, the choice of operation continues to be controversial because the prognosis is so poor. Additionally, long-term survival rates, which range from 0 % to 29 %, do not seem to differ when wide local excision or APR is performed [3][4][5]. However, some studies have shown fewer loco regional recurrences with a more radical operation, thereby supporting the use of APR for earlier-stage tumours.…”

Section: Discussionmentioning

confidence: 99%

Prolapsed Anorectal Melanoma

Savlania

2013

Indian J Surg Oncol

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Anorectal melanoma is a rare malignancy of anorectal region. Often the diagnosis is delayed because of rare entity and confusion with benign disorders like haemorrhoids. There have been only a few cases reported and the optimum management for this condition is still in dilemma, however prompt diagnosis is essential for early curative surgery. We are presenting this case, due to rare presentation of prolapse of anorectal melanoma. Keywords Anorectal malignancy . Melanoma . ProlapseFifty-five year old female presented to emergency department with complaints of irreducible mass prolapsing out of the anus since 1 day, with history of intermittent bleeding and mucoid discharge per rectum since 2 months. Before prolapse of this mass, patient was evaluated at private hospital, for intermittent bleeding and seepage of mucoid discharge per rectum, where rectal melanoma was proved by biopsy. Per abdomen and other systems examination were within normal limits. On perineal examination a large mass, blackish brown in colour, prolapsing from the anal canal is visible (Fig. 1). On per rectal examination two nodular lesions were palpable at anorectal junction adjacent to prolapsed growth and sphincter tone was reduced. Patient was anaemic, haemoglobin was 7.6 g. Her liver function test and renal function test were within normal range. Chest X-ray and abdominal computerised tomography showed no metastatic lesions. Patient optimised with transfusion of packed red blood cells. Abdomino-perineal resection with permanent end colostomy was done keeping in view of large growth, adjacent synchronous lesions, decreased sphincter tone and no metastasis. Cut open section of resected specimen showed multiple melanoma arising from anorectal

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Surgical Therapy for Anorectal Melanoma

Cited by 127 publications

References 44 publications

Optimizing local control in anorectal melanoma

Optimizing local control in anorectal melanoma

Primary anal malignant melanoma: a case report

Prolapsed Anorectal Melanoma

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