Surgical tissue adhesives

Bioadhesion: a review of concepts and applications

“…Cyanoacrylates are used as surgical adhesives owing to their wound-sealing properties and antimicrobial activity [4]. Cyanoacrylate monomers polymerize with the aid of water molecules available on the surface or present as relative humidity in the air, leading to rapid polymerization.…”

“…The latest generation of cyanoacrylate adhesives used in surgery is based on octyl-2-cyanoacrylate, and is sold under the brand name Dermabond Topical Skin Adhesive (Ethicon, Somerville, NJ, USA). This adhesive is deemed non-toxic and has been approved by the US Food and Drug Administration for topical wound closure applications [4].…”

“…Fibrin tissue adhesives can be applied below the dermis as a sealant (or haemostatic clamp) for skin grafts and flaps, and for laparoscopic surgeries [4,8]. These adhesives are typically packaged as two components, which are then mixed together during surgery.…”

“…Bioadhesion could also refer to the use of bioadhesives to bond two surfaces together, which is relevant in drug delivery, dental and surgical applications. Therefore, the wide interest in bioadhesion research is due to its implications for the development of new biomaterials, therapies and technological products such as biosensors [1][2][3][4][5][6].…”

Economic aspect of tissue glue in thyroid surgeries

“…Coover discovered the inherent adhesive properties of cyanoacrylates, which are synthetic substances and used them in surgery in the mid-20 th century. 6,7 Since then extensive descriptive and comparative studies have been conducted to confirm their role as a favourable option in closing superficial wounds. [8][9][10][11][12][13] Different cyanoacrylate compounds have been synthesised which are unique in their clinical properties.…”