Surgical Treatment and Prognosis of Esophageal Cancer After Distal Gastrectomy

Wei, Lihui; Xu, Zhifei; Zhao, Xuewei; Li, Jian-Qiu; Sun, Yinghao

doi:10.1007/s11605-009-1005-5

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Duodenal reflux is also known to be carcinogenic (48), but requires both gastroesophageal and pyloric sphincters to be defective. Distally located ESCC has been associated with severe hypochlorhydria (41) and gastrectomy (49, 50), the latter of which vastly increases the propensity for duodenal reflux (51). Countering this are our exploratory analyses which provided similar estimates of association between gastric atrophy and ESCC across esophageal sites (upper, middle, and lower thirds; Supplementary Table 1).…”

Section: Discussionmentioning

confidence: 99%

Serum Pepsinogens and Helicobacter pylori in Relation to the Risk of Esophageal Squamous Cell Carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Cook

Dawsey²,

Diaw³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Helicobacter pylori can induce gastric atrophy in humans, which in turn increases gastric cancer risk. Whether H. pylori and gastric atrophy also affect the risk of esophageal squamous cell carcinoma (ESCC), however, remains unresolved.Methods: We performed a nested case-control study within the prospective Alpha-Tocopherol, BetaCarotene Cancer Prevention Study to assess these relationships. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is composed of 29,133 Finnish male smokers, ages 50 to 69 years, who were recruited during [1985][1986][1987][1988]. Using baseline sera, we assessed H. pylori status (via immunoglobulin G antibodies against whole-cell and CagA antigens) and gastric atrophy status [via the biomarkers pepsinogen I (PGI) and pepsinogen II (PGII)] in 79 ESCC cases and 94 controls. Logistic regression with adjustment for age, date of blood draw, education, cigarette smoking, alcohol, body mass index, and fruit and vegetable intake was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI).Results: Gastric atrophy (PGI/PGII <4) was associated with ESCC (OR, 4.58; 95% CI, 2.00-10.48). There was no evidence for an association between H. pylori and ESCC (OR, 0.94; 95% CI, 0.40-2.24).Conclusions: These results could be explained by misclassification of H. pylori status due to serologic amnesia, ESCC risk being dependent on the functional consequences or interactions of H. pylori rather than the infection per se, gastric atrophy having a different histogenesis in ESCC without being primarily dependent on H. pylori acquisition, or a lack of statistical power to detect an effect.Impact: Validation of these results may warrant mechanistic studies to determine the route of association between gastric atrophy and ESCC. Cancer Epidemiol Biomarkers Prev; 19(8); 1966-75. ©2010 AACR.

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Section: Discussionmentioning

confidence: 99%

Serum Pepsinogens and Helicobacter pylori in Relation to the Risk of Esophageal Squamous Cell Carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Cook

Dawsey²,

Diaw³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The literature details various replacements. Colonic transplantation is the preferred substitution by the majority of surgeons, owing to its reliability and acceptable survival rate . Jejunal interposition reconstruction is used less frequently in cases with concomitant colonic diseases .…”

Section: Discussionmentioning

confidence: 99%

Esophagogastric reconstruction using remnant stomach with a single vessel pedicel: Technique and outcomes

You

Hou

et al. 2014

Thoracic Cancer

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Esophageal cancer with a history of distal gastrectomy is a clinical problem. To our knowledge there have been no reports of remnant stomach fed from the left gastroepiploic artery being used in esophageal reconstruction. We, herein, report four cases of esophagogastric reconstruction using remnant stomach with a single left gastroepiploic vascular pedicel. It is more functional to use the remnant stomach than other replacements. Meanwhile, the gastric conduit fed from the left gastroepiploic artery showed sufficient vascularity and stable gastroesophageal anastomosis. The technique and outcomes in follow-up have proven feasible and save time.

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Non-Acid Reflux: The Missing Link Between Gastric Atrophy and Esophageal Squamous Cell Carcinoma?

Cook

2011

American Journal of Gastroenterology

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Esophageal cancer is the eighth most common incident cancer in the world and, due to the poor survival rate it confers, ranks sixth among all cancers in mortality. In developed countries of the western world, the incidence of esophageal squamous cell carcinoma (ESCC) has undergone a decline and adenocarcinoma now constitutes approximately half of all esophageal cancers. In these relatively low-risk areas, tobacco smoking and alcohol consumption account for ~90% of ESCC cases. Eastern countries have much higher incidences of ESCC and epidemiologic evidence would suggest that there are additional unknown causal mechanisms. Gastric atrophy has consistently been associated with ESCC, but its causal relevance has been questioned. In this issue of the American Journal of Gastroenterology, Uno et al. offer evidence that a causal link between these two entities is non-acid reflux.

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Surgical Treatment and Prognosis of Esophageal Cancer After Distal Gastrectomy

Cited by 3 publications

References 13 publications

Serum Pepsinogens and Helicobacter pylori in Relation to the Risk of Esophageal Squamous Cell Carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Serum Pepsinogens and Helicobacter pylori in Relation to the Risk of Esophageal Squamous Cell Carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Esophagogastric reconstruction using remnant stomach with a single vessel pedicel: Technique and outcomes

Non-Acid Reflux: The Missing Link Between Gastric Atrophy and Esophageal Squamous Cell Carcinoma?

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