Surgical treatment for osteochondritis dessicans of the knee

Winthrop, Zachary; Pinkowsky, Gregory J.; Hennrikus, William L.

doi:10.1007/s12178-015-9304-9

Cited by 18 publications

(15 citation statements)

References 58 publications

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“…OCD is a knee osteochondral defect of unknown etiology that involves subchondral bone and articular cartilage that can spontaneously heal or cause instability or detachment of a small and overlying articular cartilage [2]. To date, there is consensus on surgical treatment for OCD lesions, based on the dimension of the lesion and stability.…”

Section: Discussionmentioning

confidence: 99%

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Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold

Gabusi

Paolella

Manferdini

et al. 2018

BioMed Research International

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Knee osteochondritis dissecans (OCD) is a focal disease of the joint characterized by modifications of bone and cartilage tissues. Biomimetic osteochondral scaffolds are used to restore these tissues. The aim of this prognostic prospective cohort study was to evaluate serum biomarkers of cartilage (fragments or propeptide of type II collagen: CTXII, C2C, and CPII) and bone (tartrate-resistant acid phosphatase (TRAP) 5b and osteocalcin (OC)) turnover during follow-up of patients treated with an osteochondral scaffold, to identify which were related to healing outcome and clinical score. We found that cartilage (CPII) and bone (OC) synthetic biomarkers were significantly increased during the first-year follow-up, while the respective degradative markers (CTXII, C2C, and TRAP5b) were not modulated. Only CTXII/CPII and C2C/CPII cartilage ratios were significantly modulated, evidencing a higher remodeling of cartilage compared to bone tissue. Cartilage and bone single biomarkers or ratios at one-year follow-up showed values close to or similar to those of healthy subjects. International Knee Documentation Committee (IKDC) score significantly increased from T0 to T2, while the Tegner score did not. Taking into consideration an IKDC score > 70 as clinical success, we found that all OCD cases with both CPII (> 300 pg/ml) and C2C/CPII (<0.35) presented IKDC scores of clinical success. OCD patients treated with an osteochondral scaffold showed an improvement at one-year follow-up, evidenced by both clinical and serum cartilage biomarkers. These data confirmed that cartilage and bone remodeling took place and showed that systemic biomarkers represent a sensitive tool for monitoring OCD patients during the follow-up.

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Section: Discussionmentioning

confidence: 99%

“…Magnetic Resonance Imaging (MRI) and radiographic evaluations are routinely used to accurately diagnose OCD lesions. To further assess cartilage and bone modifications, different studies have used histological and immunohistochemical analysis on samples collected from patients during surgical treatment [2, 7–9].…”

Section: Introductionmentioning

confidence: 99%

Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold

Gabusi

Paolella

Manferdini

et al. 2018

BioMed Research International

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“…The “classical site” of OCD lesions is the lateral aspect of the MFC. 4 , 7 Physical examination of the classical site of medial femoral OCD showed “Wilson’s sign”, during which the examiner extends the knee from 90° to 30° against resistance while internally rotating the tibia. 4 , 7 This sign is diagnostic of medial femoral OCD, causing pain due to lesion impingement on the tibial eminence.…”

Section: Discussionmentioning

confidence: 99%

Arthroscopic treatment of intra-articular dysplasia epiphysealis hemimelica of the knee

Mammoto

Hirano

2018

SAGE Open Medical Case Reports

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Dysplasia epiphysealis hemimelica, also known as Trevor Fairbank disease, is characterized by asymmetrical osteochondral overgrowth of the epiphyseal cartilage. The clinical presentation of dysplasia epiphysealis hemimelica is wide and variable, depending on the site of the lesion. Herein, we describe the physical examination of a 9-year-old boy with intra-articular dysplasia epiphysealis hemimelica, in whom the symptoms were elicited on “reverse Wilson’s sign”: bending the knee from 70° to 120° against resistance while externally rotating the tibia. Arthroscopic treatment of the intra-articular dysplasia epiphysealis hemimelica of the knee showed good outcome; hence, this modality should be considered for the management of intra-articular dysplasia epiphysealis hemimelica.

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“…As microfracture is the most widely used regenerative therapy for cartilage in current clinical practice, drilling varied holes through cartilages with an aim to recruit stem cells/progenitor cells from bone marrow is widely utilized in animal studies [18]. The microfracture procedure [19] involves debridement of the lesion to a stable rim to enable the lesion to be well contained.…”

Section: Animal Models Used In Articular Cartilage Researchmentioning

confidence: 99%

Perspectives on Animal Models Utilized for the Research and Development of Regenerative Therapies for Articular Cartilage

et al. 2016

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Animal models are integral and indispensable for biomedical research and regenerative medicine studies, as these provide invaluable information for systemically evaluating the potential risks and efficacy of newly developed biomaterials, drugs, medical devices, and therapeutic modalities, prior to initiation of human clinical trials. Nevertheless, it is important to be aware of the unique strengths and limitations of the various different small and large animal models commonly utilized for biomedical research as well as the various challenges faced in extrapolating results acquired from animal studies and the risks of data misinterpretation. This review will thus critically examine various animal models utilized for studies on articular cartilage regeneration. Particular emphasis will be placed on comparing and analyzing the unique strengths and limitations of each animal model, with the aim of establishing principles for evaluating the suitability of different animal models for individual studies as well as for comprehensive interpretation and extrapolation of results obtained from various animal species. Additionally, this review will also discuss to evaluate animal studies with in situ imaging techniques, how the animal genome may result in variability in experimental outcomes, as well as the contribution of animal models to the development of cartilage tissue engineering.

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Surgical treatment for osteochondritis dessicans of the knee

Cited by 18 publications

References 58 publications

Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold

Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold

Arthroscopic treatment of intra-articular dysplasia epiphysealis hemimelica of the knee

Perspectives on Animal Models Utilized for the Research and Development of Regenerative Therapies for Articular Cartilage

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