Surgical treatment in Paget’s disease with invasive ductal carcinoma: an observational study based on SEER

Wu, Qi; Ding, Xiaofeng; Li, Juanjuan; Sun, Si; Zhu, Shan; Wu, Juan; Liu, Qian; Feng, Yinchang

doi:10.1038/srep45510

Cited by 13 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After adjusting for other tumor characteristics and treatment approaches, we found that PD alone was not associated with inferior survival both in IDC and DCIS, supporting the consensus that the treatment strategy for MPD should be determined by the underlying breast cancer . Due to the high rate of false‐negative imaging findings and high incidence of multicentric or multifocal in situ and invasive carcinomas, the traditional surgery for PD is mastectomy with or without axillary dissection .…”

Section: Discussionsupporting

confidence: 58%

“…After adjusting for other tumor characteristics and treatment approaches, we found that PD alone was not associated with inferior survival both in IDC and DCIS, 10 supporting the consensus that the treatment strategy for MPD should be determined by the underlying breast cancer. 4,14,21,22 Due to the high rate of false-negative imaging findings and high incidence of multicentric or multifocal in situ and invasive carcinomas, the traditional surgery for PD is mastectomy with or without axillary dissection. 12 In this study, the univariate Cox regression analysis results showed that partial mastectomy was associated with a better prognosis in PD-IDC despite no significant difference in the multivariate analysis, and there was no significant difference between partial mastectomy and mastectomy in the PD-DCIS survival analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Chen

Yuan

et al. 2019

Cancer Medicine

View full text Add to dashboard Cite

Background Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone. Methods From the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD. Results PD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status ( P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status ( P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype ( P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS. Conclusions Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment.

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Chen

Yuan

et al. 2019

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…Additionally, as SEER did not report the type of LN surgery, we used the number of LNs excised as an alternative. We define patients with 1–5 LNs removed as sentinel lymph node biopsy (SLNB) and >5 LNs removed as axillary lymph node dissection (ALND), as previous studies reported 13,14. A total of 6,219 female patients with DCISM met our inclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

Risk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study

Chen

Huang

Jia

et al. 2018

OTT

View full text Add to dashboard Cite

BackgroundDuctal carcinoma in situ with microinvasion (DCISM) represents ~1% of all breast cancer cases. Risk factors for lymph node (LN) metastasis and appropriate adjuvant therapy for DCISM are still widely debated.MethodsWe retrieved DCISM data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results registry database (1998–2013). Chi-squared tests and logistic regression models were applied to investigate the potential risks of LN metastasis. Univariate and multivariate Cox proportional hazards regressions were performed to estimate the prognostic factors of DCISM. Survival outcomes were estimated using the Kaplan–Meier method. A 1:1 propensity score matching was used to minimize potential bias.ResultsOverall, 6,219 patients with DCISM met our inclusion criteria. Younger age and higher grade disease were identified as risk factors for LN metastasis. In the multivariable analysis, LN metastasis and chemotherapy were prognostic factors for worse overall survival and breast cancer-specific survival. Furthermore, propensity score matching and subgroup analysis showed that chemotherapy may not be effective for DCISM patients.ConclusionYounger patients with high-grade disease tend to have LN involved in DCISM. Adjuvant chemotherapy might not be necessary for patients with DCISM.

show abstract

“…Paget's disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1-3% of all primary breast tumors [1][2][3]. PD of the breast emerge as erythematous and ulcerated nipple.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of mammary Paget’s disease: a single-center experience in Turkey

Kar¹,

Altindag²,

Etıt³

et al. 2021

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: Paget's disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1-3% of all primary breast tumors. We aimed to evaluate and compare the clinicopathological featuresand clinical outcome of PD accompanied by in situ carcinoma and invasive cancer. Materials and Methods:We used the archive of our pathology laboratory retrospectively for age, gender, history of surgery, histopathological findings, treatment modalities and follow-up information. We used the Kaplan-Meier method for survival analysis.Results: There were 46 female patients diagnosed with PD. In 39 (84.7%) patients invasive carcinoma accompanied PD, while 7 (15.3%) patients had ductal carcinoma in situ (DCIS).The median age at diagnosis was 53.5 years. The median follow-up period was 47 months. Of the 39 invasive carcinoma 10 (25.6%) died during the follow-up period. Invasive ductal carcinoma group had a mean overall survival of rate of 57.8 ± 6.6 months. According to univariate analysis only the tumor type was found to impact overall survival (p < 0.001) Conclusions:The current study displayed the tumor type as the only parameter affecting overall survival in the invasive carcinoma group. Although it was not statistically significant, breast cancers accompanied by PD were found to be predominantly advanced stage tumors, high grade, hormon receptor negative and HER2 positive.

show abstract

Surgical treatment in Paget’s disease with invasive ductal carcinoma: an observational study based on SEER

Cited by 13 publications

References 24 publications

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Risk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study

Clinicopathological features of mammary Paget’s disease: a single-center experience in Turkey

Contact Info

Product

Resources

About