Surgical treatment of bronchial carcinoid tumors: A single-center experience

Machuca, Tiago; Cardoso, Paulo Francisco Guerreiro; Camargo, Spencer Marcantônio; Signori, Leonardo; Andrade, Cristiano Feijó; Moreira, Adriana Aparecida; Moreira, José da Silva; Felicetti, José Carlos; Camargo, José de Jesus Peixoto

doi:10.1016/j.lungcan.2010.01.015

Cited by 62 publications

(36 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The majority of the studies evaluated heterogeneous series of patients affected by lung NET, without investigating specific prognostic factors for each histotype [9-12, 14-20, 22, 24, 26, 27]. In the few studies that focused on AC populations, prognostic factors for overall survival rather than for recurrence-or disease-free survival have been evaluated [12,13,16,20,21,23,43]. To the best of our knowledge, only Filosso et al [25] analyzed disease-free survival in a group of exclusively AC patients, finding that the variables influencing disease-free survival in univariate analysis were male gender, age, and pT4 tumors.…”

Section: Discussionmentioning

confidence: 99%

Natural History of Localized and Locally Advanced Atypical Lung Carcinoids after Complete Resection: A Joined French-Italian Retrospective Multicenter Study

Marciello

Mercier

Ferollà³

et al. 2017

Neuroendocrinology

View full text Add to dashboard Cite

Background: The natural history and the best modality of follow-up of atypical lung carcinoids (AC) remain ill defined. The aim of this study was to analyze recurrence-free survival (RFS) after complete resection (R0) of stage I-III pulmonary AC. Secondary objectives were prognostic parameters, the location of recurrences, and the modality of follow-up. Methods: A retrospective review of 540 charts of AC patients treated between 1998 and 2008 at 10 French and Italian centers with experience in lung neuroendocrine tumor management was undertaken. The exclusion criteria were MEN1-related tumor, history of another cancer, referral after tumor relapse, and being lost to follow-up. A central pathological review was performed in each country. Results: Sixty-two patients were included. After a median follow-up time of 91 months (mean 85, range 6-165), 35% of the patients experienced recurrence: 16% were regional recurrences and 19% were distant metastases. Median RFS was not reached. The 1-, 3-, and 5-year RFS rate was 90, 79, and 68%, respectively. In univariate analysis, lymph node involvement (p = 0.0001), stage (p = 0.0001), mitotic count (p = 0.004), and type of surgery (p = 0.043) were significantly associated with RFS. In multivariate analysis, lymph node involvement was significantly associated with RFS (HR 95% CI: 0.000-0.151; p = 0.004). During follow-up, somatostatin receptor scintigraphy, fibroscopy, and abdominal examination results were available for 22, 12, and 25 patients, respectively. The median time interval for imaging follow-up was 10 months. Conclusions: After complete resection of AC, recurrences were observed mostly within the first 5 years of follow-up, within bronchi, mediastinal nodes, the liver, and bones. In R0 patients, lymph node involvement could help to stratify follow-up intervals. Suboptimal imaging is evidenced.

show abstract

Section: Discussionmentioning

confidence: 99%

Natural History of Localized and Locally Advanced Atypical Lung Carcinoids after Complete Resection: A Joined French-Italian Retrospective Multicenter Study

Marciello

Mercier

Ferollà³

et al. 2017

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Une différence d'environ 10 ans existe entre les 2 types tumoraux, le diagnostic étant plus tardif pour les CA [7]. Plusieurs auteurs évoquent le tabagisme comme facteur de risque surtout pour les CA [8,9]. Environ 5 % des patients atteints du syndrome des néoplasies endocrines multiples de type 1 (MEN1) développent, en plus des manifestations classiques de ce syndrome, des CB qui peuvent parfois être multiples, mais aucun cas n'a été noté dans notre série [3].…”

Section: Discussionunclassified

“…Trois quarts des CB sont visibles à la fibroscopie bronchique. La tumeur se présente, typiquement, comme un bourgeon endoluminal à surface lisse et brillante, de couleur rose-rouge et à base d'implantation sessile ou pédiculée [8]. Tumeur très vascularisée, le CB possède la réputation d'être une source redoutable de saignement lors des biopsies qui sont peu contributives, de même pour la cytologie du liquide bronchique dont l'apport est très limité [7,14].…”

Section: Discussionunclassified

Tumeurs carcinoïdes bronchopulmonaires : une série tunisienne de 115 cas opérés

Ayadi-Kaddour

Marghli

Zaïri

et al. 2015

Revue de Pneumologie Clinique

View full text Add to dashboard Cite

“…An extensive surgical resection with a lobectomy or pneumonectomy is usually performed, despite that wedge or segmental resections are alternative options in selected cases with small, localized, peripheral tumors [18]. Additionally, considering that these tumors are likely to grow along the major axis of the trachea, with potential submucosal or perineural invasion, (tracheo-) bronchoplasty has also frequently been conducted during operations [19]. Molina revealed that 70.7% salivary-type lung cancers (including all ACC and MEC tumors) presented in the trachea, carina, or main stem bronchus resulted in 9.3% sleeve lobectomies and 25.6% tracheal resections in their cases series [2].…”

Section: Discussionmentioning

confidence: 99%