Surgical Treatment of Cerebellar Cavernous Malformations: A Single-Center Experience with 58 Cases

Wu, Hongji; Yu, Tao; Wang, Shuo; Zhao, Jizong; Zhao, Yuanli

doi:10.1016/j.wneu.2015.05.062

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…Wu et al reported a statistical trend of cavernous malformations involving cerebellar peduncle towards unfavorable short-and long-term outcomes [43]. In this study four patients showed BSCM reaching into cerebellar peduncle.…”

Section: Clinical Outcomesupporting

confidence: 48%

Endoscopically Guided Resection of Brainstem Cavernous Malformations Through Miniature Corticotomies

Oertel

Fischer

Linsler

et al. 2021

Preprint

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Objective:Targeted surgical precision and minimally invasive techniques are of the utmost importance when it comes to resection of cavernous malformations involving the brainstem region. Minimization of the surgical corridor is desirable but should not compromise the extent of resection. This study provides detailed information on the role of endoscopic techniques in this challenging surgical task.Methods:A retrospective analysis of medical documentation, radiologic studies and detailed intraoperative video-documentation was performed for all consecutive patients, who underwent surgical resection of brainstem cavernous malformations between 2010 and 2020 at the authors’ institution. A case-based volumetry of the corticotomy was performed in relation to the cavernoma’s dimension. Results:A total of 20 procedures have been performed in 19 patients. Neuroendoscopy was implemented in all cases. Mean size of the lesion 5.4 (±5)mm3. Average size of the brainstem corticotomy was 4.5x3.7 (±1.0x1.1)mm with a median relation to the cavernoma’s dimension of 9.99% (1.2%-31.39%). Endoscopic 360° inspection of the resection cavity was feasible in all cases. There were no endoscopy related complications. Mean follow up was 27.8 (12-89) months. Gross-total resection was achieved in all but one cases (95%). Sixteen procedures (80%) resulted in an improved or stable medical condition. Eleven patients (61.1%) showed further improvement 12 months after initial surgery. Conclusion:Experience provided, endoscopic techniques can be safely implemented in surgery for BSCM. Combination of neuroendoscopic visualization and neuronavigation might enable a targeted size of brainstem corticotomy. Endoscopy can be considered as a valuable additive tool to ensure gross total resection of BSCM.

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Section: Clinical Outcomesupporting

confidence: 48%

Endoscopically Guided Resection of Brainstem Cavernous Malformations Through Miniature Corticotomies

Oertel

Fischer

Linsler

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Wu et al reported a statistical trend of cavernous malformations involving cerebellar peduncle towards unfavourable short- and long-term outcomes [ 50 ]. In this study, four patients showed BSCM reaching into the cerebellar peduncle.…”

Section: Discussionmentioning

confidence: 99%

Endoscope-assisted resection of brainstem cavernous malformations

et al. 2022

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Targeted surgical precision and minimally invasive techniques are of utmost importance for resectioning cavernous malformations involving the brainstem region. Minimisation of the surgical corridor is desirable but should not compromise the extent of resection. This study provides detailed information on the role of endoscopy in this challenging surgical task. A retrospective analysis of medical documentation, radiologic studies and detailed intraoperative video documentation was performed for all consecutive patients who underwent surgical resection of brainstem cavernous malformations between 2010 and 2020 at the authors’ institution. A case-based volumetry of the corticotomy was performed and compared to cavernoma dimensions. A total of 20 procedures have been performed in 19 patients. Neuroendoscopy was implemented in all cases. The mean size of the lesion was 5.4 (± 5) mm3. The average size of the brainstem corticotomy was 4.5 × 3.7 (± 1.0 × 1.1) mm, with a median relation to the cavernoma’s dimension of 9.99% (1.2–31.39%). Endoscopic 360° inspection of the resection cavity was feasible in all cases. There were no endoscopy-related complications. Mean follow-up was 27.8 (12–89) months. Gross-total resection was achieved in all but one case (95%). Sixteen procedures (80%) resulted in an improved or stable medical condition. Eleven patients (61.1%) showed further improvement 12 months after the initial surgery. With the experience provided, endoscopic techniques can be safely implemented in surgery for BSCM. A combination of neuroendoscopic visualisation and neuronavigation might enable a targeted size of brainstem corticotomy. Endoscopy can currently be considered a valuable additive tool to facilitate the preparation and resection of BSCM.

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“…Fortunately, the location of a cerebellar CCM often lends itself to surgical resection with a low risk of serious neurologic morbidity. For this reason, cerebellar CCMs can be considered for resection after a single hemorrhagic event if the risk of recurrent hemorrhage is considered significant and expected surgical morbidity is acceptable [ 1 , 28 ].…”

Section: Management Of Symptomatic Infratentorial Cavernomasmentioning

confidence: 99%

Tailored Treatment Options for Cerebral Cavernous Malformations

Hoffman

Wittenberg

Morel

et al. 2022

JPM

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The diagnosis and treatment of cerebral cavernous malformations (CCMs), or cavernomas, continues to evolve as more data and treatment modalities become available. Intervention is necessary when a lesion causes symptomatic neurologic deficits, seizures, or has high risk of continued hemorrhage. Future medical treatment directions may specifically target the pathogenesis of these lesions. This review highlights the importance of individualized treatment plans based on specific CCM characteristics.

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Surgical Treatment of Cerebellar Cavernous Malformations: A Single-Center Experience with 58 Cases

Cited by 12 publications

References 47 publications

Endoscopically Guided Resection of Brainstem Cavernous Malformations Through Miniature Corticotomies

Endoscopically Guided Resection of Brainstem Cavernous Malformations Through Miniature Corticotomies

Endoscope-assisted resection of brainstem cavernous malformations

Tailored Treatment Options for Cerebral Cavernous Malformations

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