Surgical Treatment of Induced Peri‐Implantitis in the Micro Pig: Clinical and Histological Analysis

Abstract

The purpose of this pilot study was to determine if lost osseous support adjacent to root form implants could be regenerated using a guided tissue regeneration technique. Three fixtures were placed in each edentulous mandibular bicuspid region of two micro pigs. A total of 6 fixtures were placed in each pig. Due to the presence of a pathologic condition, which was in no way related to the research, the results of one pig were not evaluated. Following osseointegration, peri-implantitis were induced by the use of ligatures and a soft diet. Three modalities of treatment were performed. Utilizing a surgical flap approach, one third of the fixtures (one per quadrant) were covered with expanded polytetrafluoroethylene (ePTFE) membrane and submerged under the soft tissue complex. The second group of fixtures were submerged under the soft tissue complex with no ePTFE membrane. The control fixtures along with their abutments were debrided and remained non-submerged. All fixtures were debrided using an air-abrasive polishing system. The osseous defects around the fixtures were measured from a fixed reference point at the time of surgery and after obtaining block sections.(ABSTRACT TRUNCATED AT 250 WORDS)

Assessment of replication of research evidence from animals to humans in studies on peri-implantitis therapy

“…6 A variety of treatments have been tested in animal models for several years to evaluate their therapeutic potential for humans. For example, systemic antibiotics, 7,8 different implant surfaces, 9 and surgical techniques with bone-regeneration procedures [10][11][12][13][14] have been intensively tested in animal models.…”

Definition, etiology, prevention and treatment of peri-implantitis – a review

“…The role of submerged healing in peri-implantitis has not been solved clearly. Although Singh et al demonstrated in 1993 greater bone regeneration and re-osseointegration during submerged healing, Grunder et al found no differences between either healing method [103,104]. …”

Implant Surface Detoxification

“…60 Four more studies comparing different types of grafts, with or without membranes, reported bone fill and pocket depth reduction at periimplant defect when an air-powder abrasive instrument for 30 seconds either alone or with sodium carbonate solution. 65 However, only 35.6% of the total amount of bone fill in the peri-implant defect was osseointegrated, whereas the remaining 64.4% of the regenerated bone fill had a soft tissue interface between bone.…”