Surgical Treatment of Lip Cancer: Our Experience With 106 Cases

Salgarelli, Attilio Carlo; Sartorelli, Francesco; Cangiano, Alessandro; Pagani, Renato; Collini, M

doi:10.1016/j.joms.2008.09.020

Cited by 46 publications

(65 citation statements)

References 45 publications

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“…Some causes such as exposure to ultraviolet light, smoking, radiotherapy, and genetic factors are held responsible for its etiology (2)(3)(4). Because it can be easily noticed because of its localization, patients can be detected in earlier stages compared with patients having other head and neck tumors.…”

Section: Introductionmentioning

confidence: 99%

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Role of Elective Neck Dissection in Early Stage Lip Cancers

Olgun¹,

Durmuşoğlu²,

Doğan³

et al. 2015

Turk Arch Otolaryngol

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Objective: To date, the management of the neck in early stage lower lip cancers remains controversial. The aim of this study is to investigate if prophylactic neck dissection is necessary in early stage lower lip cancers. Methods:Charts of 11 patients who underwent surgery of the primary site and neck because of T1-2N0 lower lip cancer between 1997 and 2011 were retrospectively examined. Clinical stages, surgeries, histopatological examination results, and loco-regional recurrences were evaluated. Results:Of the 11 patients, 10 were male (90.9%) and 1 was female (9.09%). The follow-up time of these patients was between 24-168 months (mean, 56.6 months). There were 5 patients with clinically diagnosed T1N0 tumors and 6 patients with clinically diagnosed T2N0 tumors. Suprahyoid neck dissection was performed in 4/5 T1N0 patients and supraomohyoid neck dissection was performed in the remaining 1 patient. For T2N0 tumors, 4 suprahyoid, 1 supraomohyoid, and 1 comprehensive neck dissection was performed. Histopathological examination revealed no occult metastasis in any of the patients. In 1 patient who had lower lip resection and suprahyoid neck dissection for T1N0 lower lip cancer, a contralateral neck metastasis was detected 22 months postsurgery, and a comprehensive neck dissection was performed. Conclusion:Our results show that in patients with T1N0 lower lip tumors, neck dissection may not be necessary; however, close follow-up is mandatory. Further researches with larger series dividing T2N0 tumors into subgroups for tumor size and thickness are necessary to determine neck treatment in these tumors. Keywords

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Section: Introductionmentioning

confidence: 99%

“…In cases without neck metastasis, elective neck dissection is performed. However, in literature, there is no consensus about which cases need elective neck dissection (3)(4)(5). In this study, it was aimed to investigate the place of elective neck dissection in patients with kT1 and kT2 lower lip cancer.…”

Section: Introductionmentioning

confidence: 99%

Role of Elective Neck Dissection in Early Stage Lip Cancers

Olgun¹,

Durmuşoğlu²,

Doğan³

et al. 2015

Turk Arch Otolaryngol

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“…1 Although its pathogenesis is not fully understood, unprotected chronic exposure to ultraviolet radiation is the main factor associated with the development of this neoplasm. 2,3,4,5 Although squamous cell carcinoma of the lower lip (SCCLL) is easily visualized, the first signs of occurrence of this tumor are usually neglected. Since most tumors are diagnosed in a more advanced stage and in the presence of regional lymph node metastases, their prognoses are poor.…”

mentioning

confidence: 99%

Tumor-associated macrophages (TAMs): clinical-pathological parameters in squamous cell carcinomas of the lower lip

et al. 2016

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The objective of this study was to analyze the presence of tumor-associated macrophage (TAM) subpopulations M1 and M2 in squamous cell carcinoma of the lower lip (SCCLL) by immunohistochemitry, and to evaluate the possible role of these subtypes in the development of regional lymph node metastasis and their association with clinical and pathological parameters. Forty-two cases of SCCLL were divided into two groups (21 with and 21 without regional lymph node metastasis). The histopathological grade of malignancy was determined and the material was submitted to double staining with anti-CD68/anti-CD163 and anti-CD68/anti-HLA-DR monoclonal antibodies. The results were analyzed statistically using the Wilcoxon signed-rank and Spearman correlation tests. The M1 and M2 subpopulations were observed in all cases studied. No significant difference was observed between the quantities of M1 and M2 TAMs regarding tumor size (p > 0.05). A significantly larger number of M2 compared to M1 TAMs was observed in tumors without regional lymph node metastasis, tumors in early stages, and low-grade tumors (p < 0.05). No significant difference between the numbers of M1 and M2 TAMs was observed in tumors with regional lymph node metastasis, tumors in advanced stages, and high-grade tumors (p > 0.05). There was a positive weak correlation between M1 and M2 TAMs (r = 0.361; p = 0.019). The results suggest a more important role of M2 TAMs in early stages than advanced stages of lip carcinogenesis. The progression of SCCLL does not seem to be related to an imbalance of macrophage polarization in the microenvironment of these tumors.

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“…O índice de cura esperado é de 90% para lesões com menos de 2 cm. O índice de sobrevida é maior que a média dos carcinomas da cavidade oral, ocorrendo mortes em 5-10% dos casos 4,17 . Porém recidivas podem ocorrer em 5-20% dos casos.…”

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“…O esvaziamento cervical pode ser realizado quando há suspeita de linfonodos metastáticos 4,18 . Possíveis seqüelas do tratamento incluem a diminuição da abertura bucal e da elasticidade do lábio e xerostomia quando é feita a radioterapia 4 .…”

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Proteínas e polimorfismos de genes de reparo de DNA na fotocarcinogênese em lábio

Ricardo¹

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Surgical Treatment of Lip Cancer: Our Experience With 106 Cases

Cited by 46 publications

References 45 publications

Role of Elective Neck Dissection in Early Stage Lip Cancers

Role of Elective Neck Dissection in Early Stage Lip Cancers

Tumor-associated macrophages (TAMs): clinical-pathological parameters in squamous cell carcinomas of the lower lip

Proteínas e polimorfismos de genes de reparo de DNA na fotocarcinogênese em lábio

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