Surgical treatment of macrodactyly in older children and adults

Akinci, Metin; Ay, Şadan; Erçetin, Ömer

doi:10.1016/j.jhsa.2004.07.004

Cited by 24 publications

(8 citation statements)

References 11 publications

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“…Modern treatment strategies are strictly surgical and involve either growth-limiting or digit reducing procedures, or, in severe cases, finger amputation [2], [3], [13]. Prior to this study, no molecular information was available regarding this disease.…”

Section: Discussionmentioning

confidence: 99%

Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation

et al. 2012

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Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not all tissues are equally involved and there is marked heterogeneity with respect to clinical phenotype. The molecular mechanisms responsible for these growth disturbances offer unique insight into normal limb growth and development, in general. To date, no genes or loci have been implicated in the development of macrodactyly. In this study, we performed the first transcriptional profiling of macrodactyly tissue. We found that pleiotrophin (PTN) was significantly overexpressed across all our macrodactyly samples. The mitogenic functions of PTN correlate closely with the clinical characteristics of macrodactyly. PTN thus represents a promising target for further investigation into the etiology of overgrowth phenotypes.

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Section: Discussionmentioning

confidence: 99%

Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation

et al. 2012

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“…The soft tissue and skeletal elements are diffusely enlarged in the affected digit or digits 1 2. Most cases appear sporadically without evidence of inheritance.…”

Section: Descriptionmentioning

confidence: 99%

“…Macrodactyly's management is very challenging due to its progressive and diffuse nature preventing complete correction to normal. Surgical options are either to limit ongoing growth, reduce the size of the digit or correct the deviation, as well as amputation 1 3…”

Section: Descriptionmentioning

confidence: 99%

Thumb and index finger macrodactyly with first carpometacarpal and scaphotrapezotrapezoidal joints fusion: inevitable consequence?

2017

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“…Le problème réside dans la fiabilité du pédicule dorsal, rendant cette intervention plus indiquée sur les orteils. L'oreille dorsale est retirée ultérieurement ; la résection selon Rosenberg et al [26] : l'appareil unguéal est prélevé en îlot sur le pédicule collatéral radial et positionné sur le dos de la phalange moyenne après résection de la dernière phalange et de l'interphalangienne distale ; dans les hypertrophies avec incurvation, la résection peut se limiter aux parties molles de la convexité associée à une arthrodèse avec effet accourcissant de l'articulation interphalangienne distale [27].…”

Section: Résections Combinées Osseuses Et Des Parties Molle-unclassified

“…Dans les formes statiques modérées, la résection combinée à cinq ans de recul donne une réduction stable de plus de 40 % de la circonférence du doigt et plus de 35 % de la longueur [27].…”

Section: Résultatsunclassified

Macrodactylie

Fitoussi

Ilharreborde

Jehanno

et al. 2009

Chirurgie de la Main

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There are two types of congenital enlargement of the finger. In one type, the finger is enlarged as part of a syndrome or because of a tumor or a malformation. In the other, the finger is enlarged as an isolated anomaly called "true macrodactyly", with an abundance of fat mainly on the palmar side of the finger. This condition is a rare congenital malformation and the etiology is unknow. The enlarged portion of the finger or the hand can be in a distribution of a major peripheral nerve, most often the median nerve. This condition is called nerve territory-oriented macrodactyly. Macrodactyly can be static, present at birth and does not increase disproportionately with growth, or progressive with a disproportionate growth of the digit. Treatments are difficult and challenging. The goals of operative treatments are: to control the growth in children, mainly with epiphysiodesis; to reduce the size of the finger with resection of skin and subcutaneous tissue with occasionally recession osteotomy, angulation osteotomy and arthrodesis; amputation in severe progressive macrodactyly. Parents should be informed of the potentiel number of operations necessary and of the limitation of function.

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Surgical treatment of macrodactyly in older children and adults

Cited by 24 publications

References 11 publications

Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation

Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation

Thumb and index finger macrodactyly with first carpometacarpal and scaphotrapezotrapezoidal joints fusion: inevitable consequence?

Macrodactylie

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