Surgical treatment of metastatic disease in the thyroid gland

Abstract

Metastatic disease in the thyroid gland is uncommon in clinical practice. Preoperative investigation with thyroid scan and fine-needle aspiration biopsy verified or strongly suggested metastatic disease in seven out of nine patients. All patients were treated by thyroid surgery. Three patients died within 4 months in disseminated disease. The remaining seven patients had a survival rate of between 1 and 5 years. Three patients are still alive 12, 29, and 48 months after thyroid surgery. Surgical treatment for metastatic disease in the thyroid, especially due to metastatic renal carcinoma and melanoma, is recommended.

Anaplastic Thyroid Carcinoma or Thyroid Metastasis from Cholangiocarcinoma? A Case Report

“…In a large series from the Mayo Clinic, the average size of the thyroid metastatic nodules was 3 cm [2]. The incidence of thyroid metastases secondary to any type of primary tumor is reported between 1.9-9.5% and surgical resection of the thyroid metastasis ranges between 0.02 and 1.4% [3][4][5][6][7][8]. The survival is poor, ranging between 1 and 12 months [9][10][11][12].…”

“…The survival is poor, ranging between 1 and 12 months [9][10][11][12]. Most frequently the primary tumor is renal and only two cases of thyroid metastases secondary to cholangiocarcinoma were reported on Pubmed database [3,4].…”

Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis

“…The incidence of thyroid metastases in clinical reports seems to have increased recently [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], with the most common primary carcinoma site being the kidney, followed by breast and lung [8][9][10][11][12][13][14].…”

“…Clinical reports have suggested, however, that the incidence of these metastases is increasing. The most common primary carcinoma sites in clinical reports are the kidneys, breasts, and lungs [8][9][10][11][12][13][14], although other primary carcinomas can also metastasize to the thyroid gland [15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Metastases to the Thyroid: Two Cases and a Review of the Literature

“…Silverberg and Vidone [22] described a thyroid involvement in 24% of the autopsied patients with metastatic tumors. The most common primary sites of solid tumors metastasizing to the thyroid gland (table 1) are lung, breast, kidney, and the gastrointestinal tract [1,3,8,12,14,17,18]. Single cases of ovary and uterine corpus tumors, choriocarcinoma, sarcoma, and malignant fibrous histiocytoma were documented [2,3,7,12,14,18].…”