Surgical treatment of primary macular hole using platelet-rich plasma

Shkvorchenko, D.O.; Zakharov, V.D.; Krupina, E.A.; Pismenskaya, V.A.; Kakunina, S.A.; Norman, K.S.; Petersen, E.V.

doi:10.25276/0235-4160-2017-3-27-30

Cited by 12 publications

(5 citation statements)

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“…Терапия такой плазмой является безопасным методом лечения и показания к её применению неуклонно расширяются [4]. Так, данные технологии могут быть использованы в хирургии макулярного разрыва, хирургии регматогенной отслойки сетчатки, при патологии роговицы [5][6][7][8].…”

Section: оригинальные статьиunclassified

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Popov

Куликов

Churashov

et al. 2021

Ophthalmology Reports

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BACKGROUND: In recent years, autologous serum has been increasingly used in the treatment of macular hole. The study carried out a biological analysis of autologous serum obtained by various methods. AIM: The aim of the investigation is to compare the cellular and biochemical composition of autologous serum obtained using different methods for use in the macular hole treatment. MATERIALS AND METHODS: The study of the number of platelets, leukocytes and fibrinogen level in the blood serum of 24 patients obtained by centrifugation in original systems for harvesting autologous serum and laboratory test tubes was performed. RESULTS: The indices of P-PRP obtained in the Arthrex ACP system and in a laboratory test tube do not statistically differ in quantitative indices of fibrinogen and platelets (p 0.05), and differ in the content of leukocytes (p 0.05) in the direction of increasing the number of leukocytes in the substrate obtained in a laboratory test tube. The indicators of L-PRP obtained in the Ycellbio-Kit system and in a laboratory test tube do not statistically differ in the amount of fibrinogen (p 0.05) and differ in the content of platelets and leukocytes (p 0.05) in the direction of decreasing the concentration of leukocytes and platelets in the autologous serum obtained in a laboratory test tube. CONCLUSIONS: Currently, autologous serum obtained in the Arthrex ACP system is of great interest for macular hole surgery due to the minimal content of leukocytes, the closed character of the system, and the best coagulation properties of the substrate obtained. Laboratory test tubes may be considered a more affordable alternative for the production of autologous serum (P-PRP) for the treatment of macular hole. The autologous serum (L-PRP) obtained in the Ycellbio-Kit system and in a laboratory test tube is less suitable for macular hole surgery according to its composition.

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Section: оригинальные статьиunclassified

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Popov

Куликов

Churashov

et al. 2021

Ophthalmology Reports

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“…В проведенных ранее исследованиях было получено анатомическое закрытие макулярных разрывов (МР) в 100 % случаев с применением БоТП в ходе операции [14,15].…”

Section: актуальностьunclassified

“…Для оценки результатов хирургического лечения МР и изучения морфологических изменений в зоне разрыва проводили анализ ОКТ-изображений в различные сроки наблюдения [14].…”

Section: актуальностьunclassified

OCT Angiography in Evaluation of the Macular Holes Treatment Results

Shkvorchenko¹,

Krupina²,

Фомин³

2019

Oftalʹmologiâ

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Purpose: to assess the structure of the avascular zone and Vessel Density Retina in fovea using optical coherence tomography with angiography (OCT-angiography) after surgical treatment of macular hole, (MН) with platelet-rich plasma (PRP). Patients and methods. We examined and operated 32 patients (32 eyes) with macular hole. During surgery, after posterior hyaloid and internal limiting membrane (ILM) removing the platelet–rich plazma was appliqué on the region of the hole. Оphthalmologic diagnosis and OCT angiography were performed before and in 1 and 3 months after surgery, evaluate the area of the avascular zone and Vessel Density Retina in fovea. We compared this information with a healthy eye. Results and discussion. Аll patients had significantly visual acuity increasement. Anatomical closure was confirmed in all cases. Аfter surgery, we note a decreasement in the size of the avascular zone and increasement of the Vessel Density Retina in fovea. Conclusions. OCT angiography allows to evaluate the decreasement in the size of avascular areas and increasement of the Vessel Density Retina in fovea in postoperative period.

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“…Ввиду отсутствия каких-либо теоретических обоснований и невозможности целенаправленной доставки лекарственных препаратов к макуле медикаментозного лечения макулярных разрывов не существует [4]. Общепризнанным методом лечения на данный момент остается эндовитреальная хирургия, которая заключается в проведении трехпортовой витрэктомии 25 или 27G с последующим прокрашиванием и удалением внутренней пограничной мембраны (ВПМ) с тампонадой витреальной полости газом или воздухом [4,5].…”

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Differentiated Approach to Strategies of Surgical Treatment of Idiopathic Macular Holes

Shamratov

Рамазанова

Napylova

2021

jour

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Background. 25G or 27G three-port vitrectomy, followed by staining and removal of the internal limiting membrane with vitreous cavity air or gas tamponade, is one of the main modern vitreoretinal surgery principles for primary macular holes. However, not all patients manage to obtain a functional outcome when the anatomical outcome is achieved. Purpose. To present clinical cases of surgical treatment of idiopathic macular holes (IMH) exhibiting a differentiated approach.Matherials and methods. This article analyzes clinical cases of four patients with primary idiopathic macular holes, differing in terms of development, hole diameter and the presence of comorbidities. Results. The results of surgical treatment were evaluated 14 days and 1 month after surgery. In all clinical cases, surgical treatment resulted in a positive anatomical outcome by blocking a retinal defect. Best corrected visual acuity increased, on average, from 0.08 ± 0.05 to 0.4 ± 0.05.Conclusion. The analysis of the presented clinical cases clearly demonstrates the need for a timely and differentiated approach to the treatment of patients with IMH, that considers etiology of the pathological process, period of its existence as well as concomitant and general somatic pathologies.

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Surgical treatment of primary macular hole using platelet-rich plasma

Cited by 12 publications

References 0 publications

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

OCT Angiography in Evaluation of the Macular Holes Treatment Results

Differentiated Approach to Strategies of Surgical Treatment of Idiopathic Macular Holes

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