Surgical treatment strategies for invasive thymoma

Funaki, Soichiro; Shintani, Yasushi; Fukui, Emiko; Kanzaki, Ryu; Kanou, Takashi; Ose, Naoko; Minami, Masato; Okumura, Meinoshin

doi:10.21037/jtd-19-3045

Cited by 19 publications

(8 citation statements)

References 46 publications

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“…In the same way, Funaki et al (38) reported that the combination of induction therapy and surgical resection could improve the outcome of patients with advanced locally invasive thymoma.…”

Section: Oncological Outcomesmentioning

confidence: 88%

Outcomes of extended surgical resections for locally advanced thymic malignancies: a narrative review

Tosi¹,

Damarco²,

Franzi³

et al. 2022

Gland Surg

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Background and Objective: Thymic malignancies represent the most common anterior mediastinal neoplasms, as well as rare and challenging tumors. Surgery is the cornerstone in the treatment of thymic malignancies, although a multidisciplinary approach is mandatory, for both, locally advanced or metastatic disease. In our narrative review, we explored the recent literature to investigate clinical and radiological assessment, multimodality approach and outcomes of locally advanced thymic tumors. More than one-third of patients affected by an anterior mediastinal mass are asymptomatic at diagnosis. In case of locally advanced thymoma, symptoms are related to compression or invasion of adjacent structures, such as the superior vena cava (SVC), innominate veins and pericardium. Paraneoplastic syndromes, such as myasthenia gravis (MG), are related to release of antibodies, hormones and cytokines.Methods: Diagnostic methods must be chosen accurately to avoid unnecessary surgical resections, to define the best strategy of care, and to plan the surgical strategy. Therefore, each case must be evaluated in a multidisciplinary context, where surgery plays an essential role.

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“…In the same way, Funaki et al (38) reported that the combination of induction therapy and surgical resection could improve the outcome of patients with advanced locally invasive thymoma.…”

Section: Oncological Outcomesmentioning

confidence: 88%

Outcomes of extended surgical resections for locally advanced thymic malignancies: a narrative review

Tosi¹,

Damarco²,

Franzi³

et al. 2022

Gland Surg

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“…To ensure that all lesions are resected, median sternotomy is generally chosen for invasive thymoma [ 18 ]. We gathered the data of combined thoracotomy as well, from which it could be found that the average size of the mediastinal lesions was 79.91 ± 26.99 mm, and almost all of them (84.8%) had invaded the surrounding lung tissues (Fig.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous resection of coexisting pulmonary and mediastinal lesions by video-assisted thoracic surgery: a case-series study

et al. 2022

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Background With the growing number of patients with coexisting pulmonary and mediastinal lesions detected, reports about simultaneous video-assisted thoracic surgery (VATS) for these concurrent diseases are still rare. To further explore the safety and effectiveness of simultaneous resection of pulmonary and mediastinal lesions by uniportal or biportal VATS, we retrospectively analyzed the clinical data of the largest series of cases to date. Methods From July 2018 to July 2021, all patients whose pulmonary lesions and mediastinal tumors were resected simultaneously in our institution were retrospectively reviewed. Their demographic and clinical data were collected and analyzed. Results A total of 54 patients were enrolled, of whom 44 underwent unilateral uniportal VATS, 3 underwent bilateral uniportal VATS and 7 underwent unilateral biportal VATS. Seven cases were converted to thoracotomy during surgery. For the remaining 47 patients with various demographic and clinical characteristics, most of the operations were completed within 3 h (n = 33, 70.2%) with blood loss of no more than 100 mL (n = 43, 91.5%). The duration of chest tube drainage was 5.66 ± 3.34 days, and the average daily volume was 196.90 ± 122.31 mL. Four cases of postoperative complications occurred during hospitalization. The length of postoperative hospital stay was 8.60 ± 3.63 days. No severe complications or deaths were observed during follow-up. Conclusions Uniportal and biportal VATS are safe and effective for simultaneous resection of selected coexisting pulmonary and mediastinal lesions, but the indications and operational details need more evaluation.

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“…Approximately 30% of thymomas are invasive, mainly invading adjacent organs such as the lungs, pleura, and pericardium. There have been few reports of transvenous cardiac metastasis, and thymoma of intracardiac origin is exceptionally rare [1]. Most previously reported int- racardiac thymomas originated in the right atrium and extended to the vena cava.…”

Section: Discussionmentioning

confidence: 99%

Intracardiac Thymoma with Superior Vena Cava and Left Brachiocephalic Vein Extension: A Case Report

Yun

Song

et al. 2022

J Chest Surg

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Thymomas are common anterior mediastinal tumors with a relatively favorable prognosis compared to that of other types of thoracic malignancies. However, thymomas that invade surrounding structures, such as the heart or vena cava, have been infrequently reported, and intracardiac thymomas are exceedingly rare. Treatment of invasive thymoma is difficult because the high rate of incomplete resection results in a high rate of recurrence. Herein, we present a rare case of a thymoma that originated in the right atrium and extended into the superior vena cava and brachiocephalic vein.

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Surgical treatment strategies for invasive thymoma

Cited by 19 publications

References 46 publications

Outcomes of extended surgical resections for locally advanced thymic malignancies: a narrative review

Outcomes of extended surgical resections for locally advanced thymic malignancies: a narrative review

Simultaneous resection of coexisting pulmonary and mediastinal lesions by video-assisted thoracic surgery: a case-series study

Intracardiac Thymoma with Superior Vena Cava and Left Brachiocephalic Vein Extension: A Case Report

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