Surto de toxoplasmose no município de Gouveia, Minas Gerais

Malta, Juliane Maria Alves Siqueira; Cabral, Cibelle Mendes; Nóbrega, Aglaêr Alves da; Leite, Priscila Leal e; Alves, Rejane Maria de Souza; Almeida, Sílvia; Ferraz, Marcela Lencine; J, Honorato; Ribeiro, Matilde; Silva, Letícia Mirando; Santos, Daniel V. V.; Pinto, Lorena Velozo; Costa, Júlia Gatti Ladeia; Vitor, Ricardo Wagner de Almeida; Pércio, Jadher

doi:10.12662/2317-3076jhbs.v7i3.2375.p233-241.2019

Cited by 7 publications

(7 citation statements)

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“…Whole blood samples were obtained with heparin from 21 blood bank healthy donors (HD) seronegative for T. gondii and from 29 T. gondii ‐infected patients with recently acquired toxoplasmosis from a presumed waterborne outbreak in Gouveia, a small town in the State of Minas Gerais, Southeastern Brazil 23 (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

Marino

Santos

Henriques

et al. 2020

Journal of Leukocyte Biology

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Toxoplasmosis is highly endemic worldwide. In Brazil, depending on the geographical region and socioeconomic status, 40-70% of individuals become seropositive at some point in their lives. A significant proportion of Toxoplasma gondii-chronically infected individuals who are otherwise immunocompetent develop recurrent ocular lesions. The inflammatory/immune mechanisms involved in development of ocular lesion are still unknown and, despite previous investigation, there are no reliable immune biomarkers to predict/follow disease outcome. To better understand the impact of the immune response on parasite control and immunopathology of ocular toxoplasmosis, and to provide insights on putative biomarkers for disease monitoring, we assessed the production of a large panel of circulating immune mediators in a longitudinal study of patients with postnatally acquired toxoplasmosis stratified by the presence of ocular involvement, both at the early acute stage and 6 months later during chronic infection, correlating them with presence of ocular involvement. We found that T. gondii-infected patients, especially during the acute stage of the disease, display high levels of chemokines, cytokines, and growth factors involved in the activation, proliferation, and migration of inflammatory cells to injured tissues. In particular, major increases were found in the IFN-induced chemokines CXCL9 and CXCL10 in T. gondii-infected patients regardless of disease stage or clinical manifestations. Moreover, a specific subgroup of circulating cytokines and chemokines including GM-CSF, CCL25, CCL11, CXCL12, CXCL13, and CCL2 was identified as potential biomarkers that accurately distinguish different stages of infection and predict the occurrence of ocular toxoplasmosis. In addition to serving as predictors of disease development, these host inflammatory molecules may offer promise as candidate targets for therapeutic intervention.

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Section: Methodsmentioning

confidence: 99%

Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

Marino

Santos

Henriques

et al. 2020

Journal of Leukocyte Biology

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“…Another possible explanation for the higher rate and severity of ocular involvement in our cohort is involvement of a virulent atypical T. gondii strain . However, this possibility remains elusive because parasite isolation for subsequent genotyping was not successful in the presumably contaminated water source, or in blood samples of patients with serologically confirmed infection ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…Toxoplasmosis outbreaks are good opportunities to clarify clinical aspects of this complex disease because patients are infected at known times, by similar routes, and presumably by parasites of the same genotype ( 11 – 19 ). In 2015, an outbreak of presumed waterborne toxoplasmosis was reported in Gouveia, a small city of »10,000 inhabitants in the center of the state of Minas Gerais in southeastern Brazil ( 20 ). Municipal, state, and federal health authorities investigated several cases of fever, malaise, weight loss, and lymphadenopathy.…”

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Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1

Brandão-de-Resende¹,

Santos²,

Lagos³

et al. 2020

Emerg. Infect. Dis.

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In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid; and (4) view/print certificate. For CME questions, see page 3121.

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“…No município de Montes Claros, em Goiás,Malta et al (2019 conduziram uma investigação sobre toxoplasmose, identificando inicialmente casos em 2016 e expandindo para 114 casos suspeitos. As amostras de sangue foram coletadas dos indivíduos afetados para realizar testes sorológicos com objetivo de identificar a presença de anticorpos específicos contra o Toxoplasma, tanto IgM quanto IgG.…”

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Aspectos gerais e principais agentes biológicos envolvidos em surtos de doenças veiculadas por alimentos (DVA´s): uma revisão

Silva,

Oliveira Neto

et al. 2024

OLEL

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Este estudo consistiu numa revisão breve para caracterizar o panorama epidemiológico dos surtos de doenças veiculadas por alimentos no Brasil, entre 2019 e 2024. Dos 52 artigos científicos examinados, apenas três foram considerados relevantes, com dois reportando dados de períodos anteriores ao foco da investigação. Os resultados destacam o norovírus e Toxoplasma gondii como principais agentes etiológicos recorrentes em surtos de doenças de transmissão hídrica e alimentar (DTHA), associados principalmente ao consumo de picolés, hortaliças, queijos artesanais e água. Esses achados sublinham a necessidade de aprimorar as práticas de manipulação de alimentos e vigilância sanitária. As políticas públicas, incluindo a Instrução Normativa do Ministério da Agricultura, Pecuária e Abastecimento e as Resoluções da Diretoria Colegiada da ANVISA, são essenciais para prevenção e controle de DTHA, juntamente com a fiscalização efetiva e a adoção de boas práticas de fabricação. Este estudo ressalta a importância do comprometimento de todos os atores da cadeia produtiva para garantir a segurança dos alimentos.

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Surto de toxoplasmose no município de Gouveia, Minas Gerais

Cited by 7 publications

References 2 publications

Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1

Aspectos gerais e principais agentes biológicos envolvidos em surtos de doenças veiculadas por alimentos (DVA´s): uma revisão

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