Surveillance and epidemiology of syphilis, gonorrhoea and chlamydia in the non-European Union countries of the World Health Organization European Region, 2015 to 2020

Barbarić, Jelena; Kuchukhidze, Giorgi; Seguy, Nicole; Vovc, Elena; Babovic, Maria Josefina Theresa; Wi, Teodora; Low‐Beer, Daniel; Božičević, Ivana

doi:10.2807/1560-7917.es.2022.27.8.2100197

Cited by 16 publications

(24 citation statements)

References 21 publications

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“…[30][31][32][33][34][35] It was also shown that the level of resistance to carbapenems and third-generation cephalosporin in Klebsiella pneumoniae increased. 36 Whereas tackling AMR already demanded urgent global action before COVID-19 pandemic, efforts to prioritize and enhance the implementation of effective antibiotic stewardship globally have become imperative. 6 Studies assessing AMR and consumption in primary and secondary care are needed to improve and reinforce AMS.…”

Section: What This Study Addsmentioning

confidence: 99%

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The impact of the COVID‐19 pandemic on antibiotic consumption and prevalence of pathogens in primary and secondary healthcare settings in Northern Ireland

Aldeyab

Crowe

Karasneh

et al. 2023

Brit J Clinical Pharma

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AimTo evaluate the impact of the COVID‐19 pandemic on the patterns of antimicrobial use and the incidence of pathogens in primary and secondary healthcare settings in Northern Ireland.MethodsData were collected on antibiotic use and Gram‐positive and Gram‐negative pathogens from primary and secondary healthcare settings in Northern Ireland for the period before (January 2015‐March 2020) and during (April 2020‐December 2021) the pandemic. Time series intervention analysis methods were utilized.ResultsIn the hospital setting, the mean total hospital antibiotic consumption during the pandemic was 1864.5 defined daily doses (DDDs) per 1000 occupied‐bed days (OBD), showing no significant change from pre‐pandemic (P = .7365). During the pandemic, the use of second‐generation cephalosporins, third‐generation cephalosporins, co‐amoxiclav and levofloxacin increased, there was a decrease in the percentage use of the hospital Access group (P = .0083) and an increase in the percentage use of Watch group (P = .0040), and the number of hospital Klebsiella oxytoca and methicillin‐susceptible Staphylococcus aureus cases increased. In primary care, the mean total antibiotic consumption during the COVID‐19 pandemic was 20.53 DDDs per 1000 inhabitants per day (DID), compared to 25.56 DID before the COVID‐19 pandemic (P = .0071). During the pandemic, there was a decrease in the use of several antibiotic classes, an increase in the percentage use of the Reserve group (P = .0032) and an increase in the number of community‐onset Pseudomonas aeruginosa cases.ConclusionThis study provides details of both changes in antibiotic consumption and the prevalence of infections in hospitals and primary care before and during the COVID‐19 pandemic that emphasize the importance of antimicrobial stewardship in pandemic situations.

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Section: What This Study Addsmentioning

confidence: 99%

“…Several assessments reported an increase in the rates of healthcare‐associated infections (HAIs) during the COVID‐19 pandemic 30–35 . It was also shown that the level of resistance to carbapenems and third‐generation cephalosporin in Klebsiella pneumoniae increased 36 …”

Section: Introductionmentioning

confidence: 99%

The impact of the COVID‐19 pandemic on antibiotic consumption and prevalence of pathogens in primary and secondary healthcare settings in Northern Ireland

Aldeyab

Crowe

Karasneh

et al. 2023

Brit J Clinical Pharma

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“…Several efforts have been made to improve the experience of using condoms (e.g., developing and testing new products; Beksinska et al, 2020;Coffey & Kilbourne-Brook, 2021;Gallo et al, 2022). However, recent reports worldwide show a high prevalence of STIs (Barbaric et al, 2022;Kreisel et al, 2021;Marcus et al, 2021;Sentís et al, 2021;Vives et al, 2020;Zheng et al, 2022), along with low condom use rates (Copen et al, 2022;Felisbino-Mendes et al, 2021;Fetner et al, 2020;Harper et al, 2018;Koumans et al, 2020;Lindberg et al, 2021). Inconsistent condom use may occur because condoms are mainly used for birth control and only seldom for protection against STIs (Milhausen et al, 2013).…”

Section: Portugal and Spainmentioning

confidence: 99%

Condom Use Beliefs Differ According to Regulatory Focus in Sexuality: A Multi-Method Study in Portugal and Spain

Rodrigues¹,

Carvalho²,

Prada³

et al. 2022

Preprint

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Reports worldwide have been showing increases in the rates of sexually transmitted infections (STIs) and condomless sex in recent years. Research has identified several individual and situational variables that can determine the decision to use condoms or forgo their use. We argue that such a decision can also be shaped by motives related to pleasure and safety (i.e., regulatory focus in sexuality). Using open-ended questions, we asked 742 Portuguese and Spanish adults to indicate situations and reasons that could inform the decision-making process with casual partners and the functions/attributes related to condoms. Using thematic analyses, we coded the drivers of condomless sex and condom use into themes and subthemes, and computed frequencies. Using quantitative measures, we also asked participants to indicate their condom use expectancies and perceived barriers. Comparing participants according to regulatory focus revealed some differences. Pleasure promotion participants were more likely to consider that condom use decision-making is driven by unexpectedness, pleasure, and intimacy pursuit, attached more pleasure reduction functions to condoms, expected more negative outcomes in condom use, and endorsed more sensation and partner barriers in condom use. In contrast, disease prevention participants were more likely to consider that condom use decision-making is driven by adequate sexual education, responsibility, and behavioral control, and attached more health protective functions to condoms. These differences can inform the development of tailored intervention and awareness campaigns aimed to help people to use condoms more consistently with casual partners and avoid behaviors that put them at risk of STI transmission.

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“…The World Health Organization (WHO) estimated that there were 87 million new global cases of gonorrhea in 2016 1 . Furthermore, the increasing frequency of antimicrobial resistant (AMR) Neisseria gonorrhoeae , the bacterium that causes gonorrhea, is a serious public health concern 2,3 . Historically, resistance to penicillin G, fluoroquinolones, oral cephalosporins, ceftriaxone, and azithromycin has been problematic in the treatment of gonorrhea 4 .…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a high throughputNeisseria gonorrhoeaegenotyping method

Komori

Aoki

Ishii

et al. 2023

Preprint

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Background<br>Neisseria gonorrhoeaegenotyping by whole-genome sequencing (WGS) is expensive for a large sample set, a less expensive and more efficient genotyping method is required. We developed a high-throughput genotyping method forN. gonorrhoeaeto improve molecular epidemiological typing and antimicrobial-resistant identification inN. gonorrhoeaeantimicrobial susceptibility surveillance.Methods<br> We used multiplex-tailed PCR to amplify and sequence 15 alleles from multilocus sequence typing (MLST),N. gonorrhoeaemultiantigen sequence typing (NG-MAST), andN. gonorrhoeaesequence typing for antimicrobial resistance (NG-STAR). After indexing-PCR, we sequenced the DNA library using the MiSeq platform (Illumina). Sequencing reads were de novo assembly or constructing consensus sequences of alleles, then assigned sequence type. We used 54 previously characterized strains of N. gonorrhoeae and WGS data to validate our method.Results<br> The allele identification results of MLST and NG-STAR in all strains agreed with the draft WGS. However, in NG-MAST, only 35 strains agreed. Disagreement was found in the NG-MAST of porB in 15 strains and of tbpB in seven strains. QRDR analysis perfectly predicted levofloxacin resistance. But was less successful in predicting reduced susceptibility or resistance phenotype to penicillin G, cefixime, or ceftriaxone using penA, porB, ponA, or mtrR alleles.Conclusions<br> The successful performance in MLST and NG-MAST of our method was validated in this study. This method may be useful for large-scale genotyping forN. gonorrhoeaesurveillance in a cost- and labor-saving manner. Phenotypic prediction of antimicrobial susceptibility by combining multiple alleles may be necessary for other than fluoroquinolones.

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Surveillance and epidemiology of syphilis, gonorrhoea and chlamydia in the non-European Union countries of the World Health Organization European Region, 2015 to 2020

Cited by 16 publications

References 21 publications

The impact of the COVID‐19 pandemic on antibiotic consumption and prevalence of pathogens in primary and secondary healthcare settings in Northern Ireland

The impact of the COVID‐19 pandemic on antibiotic consumption and prevalence of pathogens in primary and secondary healthcare settings in Northern Ireland

Condom Use Beliefs Differ According to Regulatory Focus in Sexuality: A Multi-Method Study in Portugal and Spain

Development and validation of a high throughputNeisseria gonorrhoeaegenotyping method

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