Respiratory tract infections (RTIs) are one of the most common infectious diseases globally imposing a significant increase in morbidity and mortality in the developing countries. There is an exponential increase in antibiotic resistance attributed to indiscriminate use of antibiotics, lack of monitoring of antibiotic susceptibility patterns, cross infections, etc. The study was carried out to isolate and identify the common bacteria causing RTIs among the patients attending two secondary care hospitals. Sputum and throat swab samples were collected from clinically diagnosed RTI in 50 patients, in an aseptic condition and then cultured on the appropriate bacteriological media. Antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion method and results were interpreted according to the Clinical Laboratory Standards guidelines. The antibiotic susceptibility testing revealed Amikacin, Gentamicin, and Ceftriaxone as highly sensitive and ciprofloxacin a widely used antibiotic in Nilgiris as the most resistant one.