Surveillance for early stages of colon cancer: potentials for optimizing follow-up protocols

Gilardoni, Elisa; Bernasconi, Davide Paolo; Poli, Silvia De; Garancini, Mattia; Luperto, Margherita; Zucchini, Nicola; Bovo, Giorgio; Totis, Mauro; Bugatti, A; Gianotti, Luca

doi:10.1186/s12957-015-0674-7

Cited by 20 publications

(22 citation statements)

References 38 publications

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“…The literature search revealed 2728 publications ( Figure 2 ). Of the 143 included for full text review, 34 were ultimately included in the meta-analysis ( Hase et al , 1993 ; Ueno et al , 2002a ; Okuyama et al , 2003a , 2003b ; Ueno et al , 2004 ; Prall et al , 2005 ; Wang et al , 2005 ; Yasuda et al , 2007 ; Kanazawa et al , 2008 ; Nakamura et al , 2008 ; Yamauchi et al , 2008 ; Lugli et al , 2009 ; Ogawa et al , 2009 ; Wang et al , 2009 ; Homma et al , 2010 ; Kajiwara et al , 2010 ; Komori et al , 2010 ; Tateishi et al , 2010 ; Akishima-Fukasawa et al , 2011 ; Reggiani Bonetti et al , 2011 ; Betge et al , 2012 ; Nakadoi et al , 2012 ; Sert Bektas et al , 2012 ; Zlobec et al , 2012 ; Wada et al , 2013 ; Huh et al , 2014 ; Lai et al , 2014 ; Nishida et al , 2014 ; Ryu et al , 2014 ; Gilardoni et al , 2015 ; Macias-Garcia et al , 2015 ; Miyachi et al , 2015 ; Tristante et al , 2015 ; Barresi et al , 2016 ). There were a total of 7821 patients included for analysis, with study groups ranging from 58 to 1114 patients.…”

Section: Resultsmentioning

confidence: 99%

“…There were considerable differences and an overt lack of standardisation of tumour budding between studies ( Table 2 ). Twenty-eight studies used standard haematoxylin and eosin (H&E) staining, four studies used immunohistochemistry (IHC) and cytokeratin staining ( Prall et al , 2005 ; Lugli et al , 2009 ; Ogawa et al , 2009 ; Zlobec et al , 2012 ), and two did not specify the technique ( Gilardoni et al , 2015 ; Macias-Garcia et al , 2015 ), although one could assume standard H&E was used. A ‘budding focus' or its equivalent was defined as an isolated cancer cell or cluster of less than five cells in 24 studies.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer

et al. 2016

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Background:Tumour budding is a histological finding in epithelial cancers indicating an unfavourable phenotype. Previous studies have demonstrated that it is a negative prognostic indicator in colorectal cancer (CRC), and has been proposed as an additional factor to incorporate into staging protocols.Methods:A systematic review of papers until March 2016 published on Embase, Medline, PubMed, PubMed Central and Cochrane databases pertaining to tumour budding in CRC was performed. Study end points were the presence of lymph node metastases, recurrence (local and distal) and 5-year cancer-related death.Results:A total of 7821 patients from 34 papers were included, with a mean rate of tumour budding of 36.8±16.5%. Pooled analysis suggested that specimens exhibiting tumour budding were significantly associated with lymph node positivity (OR 4.94, 95% CI 3.96–6.17, P<0.00001), more likely to develop disease recurrence over the time period (OR 5.50, 95% CI 3.64–8.29, P<0.00001) and more likely to lead to cancer-related death at 5 years (OR 4.51, 95% CI 2.55–7.99, P<0.00001).Conclusions:Tumour budding in CRC is strongly predictive of lymph node metastases, recurrence and cancer-related death at 5 years, and its incorporation into the CRC staging algorithm will contribute to more effective risk stratification.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer

et al. 2016

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“…8 However, the high intensity of TB was not always correlated with pathological poor differentiation, 9,10 suggesting that TB cells may have a different prognostic role compared with tumor grade in cancer. Currently, accumulating evidence supports the idea that TB can provide the most useful prognostic information in many solid tumors, including colorectal cancer, 30,31 colon cancer, 32 lung cancer, 33,34 esophageal SCC, 35 pancreatic cancer, 36 breast cancer, 37 cutaneous SCC, 38,39 and OSCC. 12 In our previous studies, we demonstrated that TB was correlated with poor prognosis and LNM, which was independent of TNM classification in oral tongue SCC.…”

Section: Publication Biasmentioning

confidence: 95%

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2018

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Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta‐analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta‐analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel‐Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1‐2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.

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“…Based on the above aspects, the present results revealed that the expression of MMP-7 was significantly associated with venous invasion in T1 CRCs. In a prospective surveillance program for early-stage CRC, venous invasion was a risk factor with a significant effect on disease-free survival, overall survival and disease recurrence (local or distant) ( 22 ). In addition, using LV-SEM, the present study observed morphological changes of collagen IV in veins.…”

Section: Discussionmentioning

confidence: 99%

“…Collagen IV is the principal structural component of the ECM in the vascular basement membrane ( 22 ). In the present study, to examine the morphological and qualitative alterations of the injured vascular basement membrane using immunostaining for collagen IV, a number of MMP-7-positive samples were selected from the 189 cases of T1 CRC.…”

Section: Methodsmentioning

confidence: 99%

Expression of matrix metalloproteinase-7 correlates with the invasion of T1 colorectal carcinoma

et al. 2018

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T1 colorectal carcinomas (CRCs) are an initial site of metastatic spread. Various risk factors for lymph node metastasis have been investigated in T1 CRCs. However, the major step in the entire process of metastasis remains unclear. In terms of carcinoma invasion and metastasis, matrix metalloproteinases (MMPs) have recently gained increasing attention. Notably, MMP-7 is frequently overexpressed in CRCs, but its implication has not been determined in T1 CRCs yet. The present study aimed to clarify the associations between the pathological risk factors of T1 CRCs and MMP-7. In the current study, 211 lesions of T1 CRC that were resected endoscopically or surgically at Showa University Northern Yokohama Hospital (Yokohama, Japan) between April 2008 and December 2009 were retrospectively analyzed. MMP-7 was immunostained and evaluated by its frequency of expression. Pathological factors of T1 CRCs were analyzed in association with MMP-7 expression. Furthermore, the ultrastructural alterations of carcinoma invasion were examined using low vacuum-scanning electron microscopy (LV-SEM). MMP-7 expression was associated with venous invasion (P=0.005), and LV-SEM revealed the disappearance of the normal structure of collagen and elastic fibers of veins invaded by tumor cells expressing MMP-7. At the invasive front, MMP-7 has a vital role in carcinoma invasion, correlating with venous invasion of T1 CRCs.

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Surveillance for early stages of colon cancer: potentials for optimizing follow-up protocols

Cited by 20 publications

References 38 publications

Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer

Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Expression of matrix metalloproteinase-7 correlates with the invasion of T1 colorectal carcinoma

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