Surveillance of Anti-Tubercular Drug Resistance

Abstract

Tuberculosis is the leading cause of death in Nepal. Failure in early detection anddrug resistance are two most important problems in treatment and cure of thetuberculosis. The objective of the study was to assess the drug resistance pattern inMycobacterium tuberculosis isolated in Tribhuvan University teaching Hospital. Morethan 85% of isolates were sensitive to all the four drugs and 5.5% of isolates weremultidrug resistant. The drug resistant isolates were obtained more frequently frompreviously treated patients. More extensive studies should be carried out by independentorganizations to collect more representative data on drug resistance tuberculosis.Key Words: Tuberculosis, drug resistance and surveillance.

Drug resistance pattern of Mycobacteria isolated from smear positive cases of pulmonary tuberculosis in eastern part of Nepal

“…In a similar study conducted at Tribhuvan University Teaching Hospital in 2000, MDR in new cases was 8.6% while 4 out of 4 (100%) strains were MDR among previously treated patients. 14 while Drug Resistance Surveillance conducted in 2007 has shown prevalence of MDR among new cases to be 2.9% and previously treated cases to be 11.7%. 15 A preliminary unpublished data of DRS carried out by GENETUP in 2011 has shown slight decline of MDR prevalence among new cases (2.6%) but a rather sharp increase (17.6%) in previously treated cases.…”