Surveillance of Chronic Wasting Disease in Sika Deer, Cervus nippon, from Tokachi District in Hokkaido

Kataoka, Natsumi; Nishimura, Masakazu; Horiuchi, Motohiro; Ishiguro, Naotaka

doi:10.1292/jvms.67.349

Cited by 16 publications

(17 citation statements)

References 15 publications

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“…22 However, no cases of CWD have been reported in Brazil. The absence of registered cases of CWD-positive animals despite the existence of susceptibility-related genotypes was also identified by Kataoka et al 25 in Cervus nippon. Therefore, the presence of the susceptibility-associated genotypes and the lack of infected animal records in Brazil are of interest because it suggests new putative threats for the conservation of these animals in the Neotropics.…”

Section: Introductionsupporting

confidence: 56%

Are Brazilian cervids at risk of prion diseases?

Falcão

Lima

Duarte

et al. 2017

Prion

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ABSTRACT. Prion diseases are neurodegenerative fatal disorders that affect human and non-human mammals. Chronic Wasting Disease (CWD) is a prion disease of cervids regarded as a public health problem in North America, and polymorphisms at specific codons in the PRNP gene are associated with this disease. To assess the potential CWD susceptibility of South American free-ranging deer, the presence of these polymorphisms was examined in Mazama gouazoubira, Ozotoceros bezoarticus and Blastocerus dichotomus. Despite the lack of CWD reports in Brazil, the examined codons (95, 96, 116, 132, 225, and 226) of the PRNP gene showed potential CWD susceptibility in Brazilian deer. Low abundancy of deer in Brazil possibly difficult both CWD proliferation and detection, however, CWD surveillance may not be neglected.

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Section: Introductionsupporting

confidence: 56%

Are Brazilian cervids at risk of prion diseases?

Falcão

Lima

Duarte

et al. 2017

Prion

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“…It has been reported that mAb 44B1 reacts with cervid PrP C , but its reactivity against the authentic PrP Sc of CWD has not been examined (8). In the present study, we demonstrated that mAb 44B1 and other antibodies are able to detect the PrP Sc of CWD (Table 2).…”

Section: (Cervus Nippon Centralis and Cervus Nippon Yesoensis)supporting

confidence: 55%

Applicability of Current Bovine Spongiform Encephalopathy (BSE) Diagnostic Procedures for Chronic Wasting Disease (CWD)

Masujin

Shimada

Kimura

et al. 2007

Microbiology and Immunology

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Chronic wasting disease (CWD) in cervids, including Rocky mountain elk (Cervus elaphus nelsoni), mule deer (Odocoileus hemionus), and white-tailed deer (Odocoileus virginianus), is one of the transmissible spongiform encephalopathies (TSEs) or prion diseases (12,16,18,19,21). TSEs are neurodegenerative disorders that include scrapie in sheep and goat, bovine spongiform encephalopathies (BSE) in cattle, and the Creutzfeldt-Jakob disease (CJD) in humans. TSEs are characterized by spongiform changes in the central nervous system (CNS) and the accumulation of an abnormal prion protein (PrP Sc ) in the CNS and lymphoid tissues; this abnormal protein is a partially protease-resistant isoform of the normal cellular prion protein (PrP C ). The PrP Sc has been recognized as a major component of the TSE pathogen and is the only known disease-specific marker (2).The occurrence of CWD has been observed in a limited region of North America (16,20). However, the geographic distribution of CWD in North America has been expanding, and it has become a serious problem in recent times (17). Moreover, it has raised concerns regarding the risk to humans. Horizontal transmission of CWD via salivation is suspected among free-ranging deer (11). However, the precise route of transmission of CWD remains obscure.There have been no reports regarding the occurrence of CWD in Japan. Recently, it has been reported that elk imported from Canada to Korea were diagnosed with CWD (15). It is necessary for animal quarantine to include precautions for CWD. At present, 2 commercial kits are adopted and used for BSE screening in Japan. For the confirmatory test using Western blotting (WB) and immunohistochemistry (IHC), several anti-prion protein (PrP) antibodies are utilized. The crossreactivity of these antibodies against both cattle and sheep PrP has been demonstrated in WB and IHC, and these confirmatory tests are also used for the diagnosis of sheep scrapie. However, the immunoreactivity of these antibodies against the PrP Sc of cervids has not been exam-

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“…Excluding these cases, it is remarkable that CWD has not been detected outside of North America, unlike scrapie of sheep or bovine spongiform encephalopathy (BSE) of cattle with cases reported virtually worldwide. Active screening efforts thus far have not detected CWD in wild cervids in Belgium, Germany, Japan, and other countries (De Bosschere et al , 2006; Kataoka et al , 2005; Schettler et al , 2006; Schwaiger et al , 2004). Wildlife management efforts to contain or eradicate CWD in Wisconsin or Colorado, where this disease is particularly widespread, have so far proven unsuccessful (Conner et al , 2007; Samuel, 2007).…”

Section: Introductionmentioning

confidence: 99%

Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein

Tamgüney

Miller

Giles

et al. 2009

Journal of General Virology

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Chronic wasting disease (CWD) is a transmissible, fatal prion disease of cervids and is largely confined to North America. The origin of CWD continues to pose a conundrum: does the disease arise spontaneously or result from some other naturally occurring reservoir? To address whether prions from sheep might be able to cause disease in cervids, we inoculated mice expressing the elk prion protein (PrP) transgene [Tg(ElkPrP) mice] with two scrapie prion isolates. The SSBP/1 scrapie isolate transmitted disease to Tg(ElkPrP) mice with a median incubation time of 270 days, but a second isolate failed to produce neurological dysfunction in these mice. Although prions from cattle with bovine spongiform encephalopathy (BSE) did not transmit to the Tg(ElkPrP) mice, they did transmit after being passaged through sheep. In Tg(ElkPrP) mice, the sheep-passaged BSE prions exhibited an incubation time of approximately 300 days. SSBP/1 prions produced abundant deposits of the disease-causing PrP isoform, denoted PrPSc, in the cerebellum and pons of Tg(ElkPrP) mice, whereas PrPSc accumulation in Tg mice inoculated with sheep-passaged BSE prions was confined to the deep cerebellar nuclei, habenula and the brainstem. The susceptibility of ‘cervidized’ mice to ‘ovinized’ prions raises the question about why CWD has not been reported in other parts of the world where cervids and scrapie-infected sheep coexist.

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Surveillance of Chronic Wasting Disease in Sika Deer, Cervus nippon, from Tokachi District in Hokkaido

Cited by 16 publications

References 15 publications

Are Brazilian cervids at risk of prion diseases?

Are Brazilian cervids at risk of prion diseases?

Applicability of Current Bovine Spongiform Encephalopathy (BSE) Diagnostic Procedures for Chronic Wasting Disease (CWD)

Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein

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