Surveillance of Human Rotavirus in Wuhan, China (2011–2019): Predominance of G9P[8] and Emergence of G12

Zhou, Xuan; Pang, Bei-Bei; Chen, Nan; Kobayashi, Nobumichi

doi:10.3390/pathogens9100810

Cited by 18 publications

(21 citation statements)

References 73 publications

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“…22 G9P [8] has been the most prevalent strain in China. 32 This was also true in this study; although the RV strain circulating in the pediatric population changed unpredictably from year to year, G9P [8] is still the most dominant single strain of RV infection among children <5 years of age in Suzhou, with certain persistence from 2013 to 2019. 33 The first emergence of G9P [8] was in the 1980s, 7 and then G9P [8] has spread worldwide, which gained predominance in several nations (eg, Thailand, Ghana, Australia, 25,34,35 as well as China 36 ).…”

Section: Discussionsupporting

confidence: 63%

Rotavirus Infection in Children <5 Years of Age in Suzhou, China, 2013–2019

Shen

Ren

Chen³

et al. 2022

Pediatric Infectious Disease Journal

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Background: This study aimed to determine the disease burden and strain distribution of rotavirus in children with diarrhea <5 years old in Suzhou, China. Methods: The study was conducted among children with diarrhea <5 years old at Suzhou University Affiliated Children's Hospital from 2013 to 2019. Rotavirus antigen was detected in clinical laboratory and then sent to Suzhou Centers for Disease Control and Prevention for further molecular analysis. Group A rotavirus (RVA) was detected through enzyme-linked immunosorbent assays, and G-genotype and P-genotype of RVA were tested using reverse transcription-polymerase chain reaction. Results: Of a total of 198,130 children with diarrhea, 70,813 (35.7%) were positive for RVA; RVA-related diarrhea was detected in 7798 (20.7%, n = 7798/37,710) inpatients and 63,015 (39.3%, n = 63,015/160,420) outpatients. Most children (92.0%, n = 65,171/70,813) positive for RVA were found as children <3 years old. Children 12-35 months old were reported as the highest prevalence among all age groups. The seasonal peak of RVA was in the autumn and winter. Among all 673 RVA strains genotyped, the G9P[8] strain was reported to be persistently predominant in the pediatric population from 2013 to 2019. Conclusions: The burden of diarrhea disease due to rotavirus infection remains high in Suzhou.

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Section: Discussionsupporting

confidence: 63%

Rotavirus Infection in Children <5 Years of Age in Suzhou, China, 2013–2019

Shen

Ren

Chen³

et al. 2022

Pediatric Infectious Disease Journal

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“…Supportively, Fukuda et al, have currently reported three strains of DS‐1‐like G9P[8] with gene constellation G9‐P[8]‐I2‐R2‐C2‐M2‐A2‐N2‐T2‐E2‐H2 in Thailand, containing both genogroup 1 and 2 genes 77 . Several previous studies have also detected mono‐reassortant G9P[8] strains possessing the NSP4 gene of the E2 genotype in the genetic background of Wa‐like RVA in Japan 69,78 and China, 68 which seemed to be reassorted with the NSP4 gene of E2 genotype of the G2P[4] strains. The findings of the present study also indicated that some of the I1 and E1 genotypes were in association with their corresponding VP7 and VP4 genotypes ( n = 6, G1P[8]‐I1‐E1; n = 9, G9P[8]‐I1‐E1).…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: Emergence of uncommon G9P[4] and G9P[8] rotavirus strains

Kachooei

Tavakoli

Minaeian

et al. 2023

Journal of Medical Virology

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The present study was conducted to monitor the genotypes of circulating species A rotavirus (RVA) in Iran and investigate genetic linkages between specific RVA VP7, VP4, VP6, and NSP4 segments. For this purpose, 48 RVA strains were detected during the 2021–2022 seasons. The two combinations of G9P[4] and G9P[8] RVA strains were predominant. However, several other combinations of RVA also were detected. Based on the distribution of I and E genotypes (46 strains) with respect to G and P, the most common strains were G9P[4]‐I2‐E2 (19.5%), G9P[4]‐I2‐E1 (6.5%), G9P[4]‐I1‐E1 (4.3%), G9P[8]‐I1‐E1 (19.5%), and G9P[8]‐I2‐E2 (10.9%), which were followed by several other combinations of G and P RVA strains with different pattern of I‐E genotypes and also emerging, rare and uncommon strains. The present study described the continued circulation of G9 strains with the emergence of uncommon G9P[4] and G9P[8] reassortants with three and two different I‐E genotypes, respectively, which have not been reported previously in Iran. Our findings indicated that these uncommon strains exhibited a unique genotype pattern comprising a mixture of genogroup 1 and 2 genes and suggest the need for further analysis of rare, uncommon, and emerging strains of RVA at all 11 gene segments to determine intergenogroup and intragenotype reassortments.

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“…The prevalence of RVA in adults with diarrhea ranged from 2.8% to 17.2% according to studies from India, Russia, Germany, and other countries 6–9 . In China, RVA prevalence in adults with diarrhea has ranged from 10.9% to 30.1% 10–12 …”

Section: Introductionmentioning

confidence: 99%

“…In China, a national surveillance network for rotavirus diarrhea is aimed at children under 5 years of age and does not include adults. Although some studies have reported RVA prevalence in adults with diarrhea in China, 19–22 genotyping and phylogenetic analysis were seldom performed, except for studies conducted in Wuhan 10,23,24 and Shanghai 11,15 . G3P[8] was the predominant strain of RVA affecting both adults and children in Wuhan from 2000 to 2006 24 .…”

Section: Introductionmentioning

confidence: 99%

Group A rotavirus prevalence and genotypes among adult outpatients with diarrhea in Beijing, China, 2011–2018

Tian

Gao

et al. 2021

Journal of Medical Virology

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Group A rotavirus (RVA) is one of the most common causes of severe diarrhea in children worldwide. However, RVA is also an important pathogen causing adult diarrhea, with higher infection rates in older patients. To provide evidence for rotavirus epidemic control and to inform vaccine development, we analyzed the molecular epidemiology of RVA among adult outpatients with diarrhea in Beijing from 2011 to 2018. Stool specimens were collected monthly from 14 districts. RVA was detected using enzyme-linked immunosorbent assay and real-time reversetranscription polymerase chain reaction (RT-PCR). Genotyping of rotavirus was performed using multiplex semi-nested RT-PCR. Phylogenetic analysis was performed using maximum likelihood methods implemented in MEGA software (version 6.06). Logistic regression and chi-square tests were used to assess differences among age groups, districts, years, and genotype distributions. The prevalence of rotavirus was 10.16% (1310 of 12,893) among adult outpatients with diarrhea from 2011 to 2018 in Beijing. The highest prevalence (13.74%, 600 of 4367) was observed among those aged 41 to 65 years. November, December, and January had the highest positive detection rates. In 2011, G3P[8] and G9P[8] were the dominant genotypes. Starting from 2012, G9P[8] became the dominant genotype. Most G9 strains belonged to the G9-VI clade. Most P[8] strains belonged to the P[8]-III clade. RVA is a major cause of adult diarrhea in Beijing. Continuous molecular surveillance is needed, and transmission of rotavirus between children and adults should be investigated further. K E Y W O R D S adults, diarrhea, genotype, group A rotavirus, outpatients 1 INTRODUCTION Group A rotavirus (RVA) is one of the most common causes of severe diarrhea in children worldwide. Global cases of diarrhea were estimated at 6.29 billion (95% uncertainty interval [UI], 5.81-6.82 billion) in 2017, with RVA prevailing as the leading etiology. 1 A total of 128,500 (95% UI, 104,500-155,600) children died of RVA infection worldwide in 2016, with 104,733 (95% UI, 83,406-128,842) deaths occurring in sub-Saharan Africa. 2 Many studies have reported the epidemiological characteristics, burden of disease, clinical manifestations, and genotype distributions of RVA diarrhea among children in China and other countries. 3,4 However,RVA is also an important pathogen causing adult diarrhea, with a higher infection rate in older individuals. 5 The prevalence of RVA in adults with diarrhea ranged from 2.8% to 17.2% according to studies from India,

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Surveillance of Human Rotavirus in Wuhan, China (2011–2019): Predominance of G9P[8] and Emergence of G12

Cited by 18 publications

References 73 publications

Rotavirus Infection in Children <5 Years of Age in Suzhou, China, 2013–2019

Rotavirus Infection in Children <5 Years of Age in Suzhou, China, 2013–2019

Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: Emergence of uncommon G9P[4] and G9P[8] rotavirus strains

Group A rotavirus prevalence and genotypes among adult outpatients with diarrhea in Beijing, China, 2011–2018

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