Surveillance Study of Epidemiology, Antifungal Susceptibility and Risk Factors of Invasive Candidiasis in Critically ill Patients

Wang, Bo; Wang, Yuerong; Zhang, Luwen; Lu, Fanbo; Zhang, Min; Xu, Yuanhong

doi:10.7754/clin.lab.2021.211001

Cited by 2 publications

(1 citation statement)

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“…C. albicans , as an opportunistic pathogen, mainly causes skin, mucosa, and even systemic infection of immunocompromised individuals [ 31 ]. Invasive infections caused by Candida are a great threat to human health.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Chen

Liu

et al. 2023

Virulence

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Candidiasis caused by Candida albicans infection has long been a serious human health problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are novel targets of antifungal drugs for low risk of resistance development. In this study, we identified a maleimide compound [1-(4-methoxyphenyl)-1hydro-pyrrole-2,5-dione, MPD] that exerts effective anti-virulence activity. It could inhibit the process of adhesion, filamentation, and biofilm formation in C. albicans . In addition, it exhibited low cytotoxicity, hemolytic activity, and drug resistance development. Moreover, in Galleria mellonella-C. albicans ( in vivo ) infection model, the survival time of infected larvae was significantly prolonged under the treatment of MPD. Further, mechanism research revealed that MPD increased farnesol secretion by upregulating the expression of Dpp3. The increased farnesol inhibited the activity of Cdc35, which then decreased the intracellular cAMP content resulting in the inhibition of virulence factors via the Ras1-cAMP-Efg1 pathway. In all, this study evaluated the inhibitory effect of MPD on various virulence factors of C. albicans and identified the underlying mechanisms. This suggests a potential application of MPD to overcome fungal infections in clinics.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Chen

Liu

et al. 2023

Virulence

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Invasive Candidiasis Due to Candida albicans and Its Treatment

Aquiles Hidalgo Acosta,

Fernanda Calderón León,

del Carmen Quisiguiña Jarrin

et al. 2024

Candida Albicans - Epidemiology and Treatment

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Invasive candidiasis secondary to Candida albicans should be highly suspected in patients exposed to the various risk factors that contribute to the affectation of this fungus, in order to provide early management of sepsis, through the use of antifungals in a timely manner, and to avoid the development of multiorgan failure. Diagnosis is fundamental and is based on laboratory studies, cultures, and risk scales; however, there are still limitations due to the fact that they do not have 100% sensitivity or specificity. Echinocandins remain the first line of treatment for patients with invasive candidiasis associated with C. albicans. Invasive candidiasis can affect any organ and increase mortality in adult and neonatal intensive care unit patients.

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Surveillance Study of Epidemiology, Antifungal Susceptibility and Risk Factors of Invasive Candidiasis in Critically ill Patients

Cited by 2 publications

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Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Invasive Candidiasis Due to Candida albicans and Its Treatment

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