Survey of Clinical Significance of Serum Mucoprotein Level

The constancy of the alpha-1-acid glycoprotein variants of normal adults under conditions of severe stress.

“…The increase in the a,-acid glycoprotein blood level, nonspecific in nature and often referred to as a phase reactant (2,28), has usually been measured indirectly by determining the concentration of seromucoid fractions (15,29) and occasionally by immunochemical analysis (30)(31)(32). In the present study, the blood concentration of a,-acid glycoprotein was measured for the first time directly by isolating this protein from the serum.…”

The Plasma Vitamin B12 Binding Substance: I. Its Detection in the Seromucoid Fraction of Plasma From Normal Subjects and Patients With Chronic Myelo-Cytic Leukemia *

“…Total seromucoid is also known to rise in a variety of diseases associated with traumatic, inflammatory or degenerative tissue changes. These findings have been well reviewed by Winzler (23), Greenspan (25), and Moschides, Stefanini, Magalini and Kistner (26). In addition, however, there is evidence that the carbohydrate to protein ratio of seromucoid may vary in different diseases (27,28) and also that the relationship between carbohydrate components themselves may vary (29).…”

Content and Composition of the Mucoprotein Fraction of Human Serum (Seromucoid) in Disease, With Special Reference to Hematologic Disorders1

“…Elevated in diabetes mellitus with complications (14), myocardial infarction (37), carcinoma and pneumonia (19), rheumatic fever (38), trauma (12). Decreased in liver disease, some endocrine dysfunctions, nephrosis (12).…”

“…Decreased in liver disease, some endocrine dysfunctions, nephrosis (12). Elevated in rheumatoid arthritis (15 Tables II and III show that dilution and molarity of perchloric acid were of relatively little bearing on the final yield of mucoproteins.…”