Survey of coverage, strategy and cost of hepatitis B vaccination in rural and urban areas of China

Zeng, Xinyi; Yang, Gonghuan; Liao, Susu; Chen, Aiping; Tan, Jian; Huang, Zhengjing; Li, Hui

doi:10.3748/wjg.v5.i4.320

Cited by 16 publications

(8 citation statements)

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“…The antibody response to HB vaccine has been found occurring in more than 90% of the healthy vaccinees [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] . Kinetic studies showed serum anti-HBs levels decreased with time following vaccination [5,9,14,16] .…”

Section: Introductionmentioning

confidence: 99%

Long term persistence of T cell memory to HBsAg after hepatitis B vaccination

Wang¹,

Boland²,

Hattum³

et al. 2004

WJG

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AIM:To determine if the T cell memory to HBsAg can persist for a long time after hepatitis B (HB) vaccination. METHODS:Thirty one vaccine recipients who were healthcare workers (18 females and 13 males aged 34-58 years) from Utrecht University Hospital, Netherlands, and had previously received a standard course of vaccination for hepatitis B were investigated and another 9 unvaccinated healthy volunteers from the same hospital were used as the control. Blood samples were taken just before the experiment to test serum anti-HBs levels and the subjects were classified into different groups according to their serum titers of antiHBs and vaccination history. Their peripheral blood mononuclear cells (PBMC) were isolated from freshly heparinized venous blood and the proliferative response of T lymphocytes to the recombinant hepatitis B surface antigen (HBsAg) was investigated. RESULTS:Positive serum anti-HBs was found in 61.3% (19/31) vaccine recipients and a significant in vitro lymphocyte proliferative response to recombinant HBsAg was observed in all the vaccinees with positive anti-HBs. Serum anti-HBs level 10 IU/L was found in 38.7% (12/31) subjects. In this study, we specially focused on lymphocyte proliferative response to recombinant HBsAg in those vaccine recipients with serum anti-HBsAg less than 10 IU/L. Most of them had received a standard course of vaccination about 10 years before. T lymphocyte proliferative response was found positive in 7 of the 12 vaccine recipients. These results confirmed that HBsAg-specific memory T cells remained detectable in the circulation for a long time after vaccination, even when serum anti-HBs level had been undetectable. CONCLUSION:The T cell memory to HBsAg can persist for at least 10 years after HB vaccination. Further booster injection is not necessary in healthy responders to HB vaccine.Wang RX, Boland GJ, van Hattum J, de Gast GC. Long term persistence of T cell memory to HBsAg after hepatitis B vaccination.

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Section: Introductionmentioning

confidence: 99%

Long term persistence of T cell memory to HBsAg after hepatitis B vaccination

Wang¹,

Boland²,

Hattum³

et al. 2004

WJG

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“…An earlier survey reported that the coverage rate of HBV vaccine among neonates was 96.9 and 50.8% in the urban and rural disease surveillance points, respectively, of 25 provinces in 1993-1994 [26], but in remote rural areas, the rate was still only 31.6% in 2004 [27]. As a universal neonatal vaccination programme was launched only in 2005 [28], it can be envisaged that adults from Mainland China have probably not received any immunoprotection.…”

Section: Discussionmentioning

confidence: 90%

Correlation between maternal hepatitis B surface antigen carrier status with social, medical and family factors in an endemic area: have we overlooked something?

et al. 2011

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“…17 However, there still are 130 million carriers 18 Chronic hepatitis B is a serious liver disease associated with significant mortality and morbidity. During the long course of chronic hepatitis B, various exacerbation factors may lead some patients to develop chronic severe hepatitis B, which is almost always fatal in terminal stage.…”

Section: Discussionmentioning

confidence: 99%